refers to the movements of drug molecules to target tissues of the body via circulation in the blood
Drugs do not know where to go once they enter circulation. They simply ______ throughout the body and effect only the receptors that interact with them.
____ ____ drug molecules that enter circulation become available to affect the nervous system
bind to blood proteins
drug molecules _____ __ ______ _______ forming an equilibrium between bound and free molecules
metabolized by the liver
some molecules are __________ ______ ______ _________ before they ever reach the brain.
blood brain barrier
psychoactive drugs molecules must pass the _____ ____ _______ to exert effects on the nervous system
______ carry oxygenated blood FROM the lungs to capillaries.
__________ are the tissues of the body that exchange Oxygen/Co2 and nutrients/waste products.
________ carry oxygen depleted blood through the liver to remove wastes/toxins before returning to the lungs
Capillaries are very small blood vessels between arteries and veins that are composed of loosely connected __________ cells
enothelial cells permit the _________ of nutrients and waste products between tissues and ciruclating blood
capillaries of the brain that are surrounded by fatty __________ cells that press the endothelial cells together form the BBB that prevents many substances in the blood from entering the brain
the BBB ______: hormones, charged particles (ions), large molecules and various infectious agents.
the BBB ______: O2 and CO2 xfr. Nutrients, amino acids and essential substances via active transport, small fat soluble molecules (psychoactive drugs)
lack blood brain barrier
brain areas that _______ the _____ _____ _____: pineal gland, pituitary gland, area postrema (aka medulla)
drug elimination refers to the processes by which drug molecules are ___________ and _________ from the body
the _______ is the primary organ responsible for metabolizing drug molecules
__________ ________ break down molecules into non-psychoactive (usually) and more water soluble forms
water soluble metabolites are removed from circulation by the __________ and then excreted from the body in _____.
frequent exposure to a drug can __________ ________ liver enzyme production to more efficiently metabolize druge molecules