MOD Asthma drugs (everything else)
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18 terms
Terms | Definitions |
|---|---|
 Antimuscarinics | inhibit effect of vagal released achtycholine at M3 receptor of bronchial smooth muscle cells |
| Atropine | highly permeable to respiratory epithelium |
| Ipratropoum | Anti-Muscuarnic, not approved for Asthma and an add on to inhaled corticosteroids |
| SE of AM's | Limited absorption |
| AM vs B2 ADR | AM's are less efective than B2 agonists in chronic asthma as high vagal tone in acute asthma |
| methylxanthines | bronchodilates via inhibition of phosphodiesterase and also by antangonism of adenosine |
| Caffeine | weak bronchodilator, adenosine receptor antagonist |
| Theophylline | oral, slow, weak bronchodilator. enhances the effects of B2 ADR's and prominent anti-inflammatory effects |
| SE of Theophylline at 15 mg/L | arrhythmias and seizures |
| Anti inflamm agents | Inhibit release of mediators (glucocorticoids, mast cell stablizers and Anti- IgE antibody and block effects ofmediators |
| Muscarinic receptors | bronchoconstriction |
| B2 ADR | broncodilation |
| Corticosteroids MoA | antiinflammatory action which reduces responseiveness, decrease the prodiction of prostaglandins and leukotrienes |
| Inhaled Corticosteroids | Inhaled for acute attacks and prophylaxis |
| Bechlomethasone,Triamcinolone,fluctiasone | Inhaled GC's |
| Prednisone | Oral for severe accute attacks |
| Corticosteroid effectiveness | Effective when pts are not responsive to broncodilators and major concerns are oropharyngeal candidiasis, hoarseness, and affects children's growing |
| Combination of B2 ADR and Corticosteroids | Used in pts with moderate to severe persistent asthma when symptoms are not controlled by inhaled corticosteroids alone |
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