← Diueretics Test
3 Written Questions
2 Multiple Choice Questions
- Works on Na+/Cl- on the DCT apical membrane side; stops Na+ reuptake.
Increase Ca2+ reuptake, H+ (so if more H+ than more HCO3 in base! Fleet's stuff!)
Chronic hypertension (sustained), HF, Kidney stones, Osteoporosis + diuretic.
- Na+ or Na+/H+ channels on apical membrane of PCT, DCT, Collecting Duct.
(-) Mv inside so less K+ loss, more HCO3 in urine - metabolic acidosis. Uricosuric effect.
With Thiazides! Hyperkalaemia risk - take out K+ supplements.
2 True/False Questions
Carbonic Anhydrase Inhibitor: Acetazolmide → Stops supply of H+, decrease Na+/H+ exchange on apical membrane of PCT, DCT (little effect).
Hypokalaemia - exchange to get Na+ back.
Alkaline urine - HCO3 trapped in urine.
Used in alkalinization of urine, glaucoma, mountain sickness (produce acidosis to offset), epilepsy (decreases pH)
Xanthines: Caffeine, Aminophylline (Oral - asthma) → Weak, increased tolerance, works on Na+/H+ on PCT apical membrane.
Inhibit PDE, afferent arteriole dilation (increase GFR, asthma).