diffuse involves all the gloms, focal spares some of the gloms
Contrast focal and diffuse glomerulonephropathy
global involves all of the glom, segmental spares some parts of the glom
Contrast global and segmental GN
nephrosclerosis from high BP is focal-global
What disease breaks the diffuse-global and focal-segmental pattern?
sclerosis which is extra mesangial matrix / basement membrane material
What kind of nephrotic scarring is strongly PAS+ and stains black with silver stain?
fibrosis which is collagenous scarring
What kind of nephrotic scarring is weakly PAS+ and does NOT stain black with silver stain?
Diffuse Proliferative GN
What GN presents with large irregularly spaced subepithelial deposits, endothelial cell edema, course granular regeneration and neutrophils?
staph, viral infections, endocarditis, lupus
What diseases cause Diffuse Proliferative GN?
Anti-GBM / Goodpasture's RPGN
What presents with fibrin cresents in the glom and linear immunofluoresence but no immune deposits or specific changes?
type 1 is Anti-GBM. Type 2 is Immune Complex Disease. Type 3 is Vasculitis.
What are the 3 types of Rapidly Progressing GN?
What GN presents with deposits and proliferation in the mesangial cells and "tree in winter" immunofluor pattern?
IgA disease, Lupus, Zuni, other mild disease
What causes Mesangial GN?
What presents with small, evenly-spaced subepithelial deposits with the GBM grow up around them like spikes and fine granularity?
idiopathic, lupus, HBV, HCV
What diseases cause Membranous GN?
Minimal Change GN
What disease presents commonly in children with no visible change in the Renal Capsule except fused food processes?
Focal Segmental GN
What presents with fused foot processes, enlarged Gloms, sclerosis (extra mesangial matrix and GBM) and no immune deposits?
idiopathic, AIDS, heroin, reflux, hyperinfiltration
What diseases cause Focal Segmental GN?
Membranoproliferative GN type 1
What presents with double/split GBM (tram tracks), course granularity, and various immune deposits?
idiopathic but C3 nephritic factor and Ab that stabilize C3 convertase ID'd
What diseases cause Membranoproliferative GN type 1?
Membranoproliferative GN type 2
What presents with double/split GBM (tram tracks), worm pattern C3 stains and "dense deposit" broad bands of C3 but no Ig?
dense deposit disease
What diseases cause Membranoproliferative GN type 2?
Bad Lupus Glomerulopathy
What presents with "wire loop" megadeposits, coarse granularity with mixed chunks and other changes?
diabetes, diffuse glomerulosclerosis
What causes basement membranes throughout the body to thicken and what is the process called in the Glom?
What is the term for the nodules of mesangial cells that form sometimes in diabetes?
What disease is stained with Congo Red and flashes apple green under polarized light?
Monoclonal Light Chain Nephritis
What presents with mesangial nodules that stain as light chains?
What presents with GBM in a woven basket pattern, hearing loss and renal failure?
What disease presents as crude in the glom stained by methylene blue?