CV stimulants
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24 terms
Terms | Definitions |
|---|---|
 Small doses of Epi may do what? | decrease BP, because B2 vasodilator is more sensitive than the constrictor A receptors |
| Why is Epi coformulated with local anesthetics? | local vasoconstrictive effects slows absorption to keep injection where the dentist wants it to be |
| What does Epi do to heart? | powerful and direct cardiac stimulant, increases HR, shortens systole, increases CO, increases O2 consumption |
| Do catecholamines predispose to arrthymias? | yes they also predispose to sudden cardiac death |
| What does Epi do to coronary blood flow? | increases it, increases diastole duration and aortic pressure |
| What is epi good for in patients with cardiac arrest? | restoration of cardiac rhythm |
| what can be given if NE leaks out (would cause bad necrosis!) | phentolamine |
| what does NE do to CO, TPR, and SV? | decreases CO, increases TPR, increases SV |
| What is low dose dopa good for? | D1 action, vasodilates, good for improving GFR/renal perfusion/urine output |
| What does moderate dose dopa do? | D1 and B1 action, increases CO, and some D1 vasodilation |
| What does high dose dopa do? | Alpha agonist action, increases PVR and renal vasoconstriction |
| what receptor activity for Dobutamine | B agonist, enantiomers (+/-) A1 agonist (should cancel out) |
| what is T1/2 of dobutamine? | 2 min |
| what does dobutamine do to CO, SV, and HR | increases CO increases SV does nothing to HR |
| What would dobutamine be used for? | short term treatment of cardiac decompensation (after cardiac surgery, CHF, acute MI) |
| What does isoproterenol do to CO and diastolic BP? | raises CO lowers diastolic BP |
| when should isoproterenol be used? | in emergencies to stimulate HR in pts with heart block/bradycardia, esp before insertion of pacemaker, and in pts with torsades de pointes |
| What receptors does phenylephrine work on? | alpha |
| what does this do to arteries, BP, HR, CO | arterial vasoconstriction, raises BP, leading to a reflex drop in HR and CO |
| When might phenylephrine be useful? | control of hypotension associated with epidural (regional or spinal anesthesia) |
| where does ephedrine work? | direct agonist and alpha and beta receptors enhances NE release |
| what does ephedrine do to HR, CO, TPR, BP | raises everything |
| what can ephedrine cause? | fatal arrhythmias, v fib |
| What ephedra containing herbs have been banned? | herbal products containing ephedra alkaloids, also ephedra is precursor of amphetamine and methamphetamine |
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