Phase 2 P450 System
Enzyme system associated with glucosinolate anticarcinogenic properties, upregulated by isothiocyanates.
Diminished endogenous antioxidant protection
Common cause of oxidative stress in an organisim
Test tube analysis that measures the total antioxidant power of a sample.
Chewing and gut bacteria
Two ways glycosinolate converts to bioactive form in the body
Water-soluble compounds leach into the water, myrosinase denatured by heat.
Two ways boiling affects availability of glucosinolates in food.
Endogenous factor affecting bio-availability of bioactives
Exogenous factor affecting bio-availability of bioactives
Most active form of glucosinolate found in broccoli (according to Herr and Bucher)
Unknown if exogenous compounds act as free radical scavengers, concentration of dietary antioxidants found in vivo are not large enough to compete with endogenous antioxidants, low phytochemical
doses activate signaling pathways that result in increased expression of genes encoding cytoprotective proteins, but
high doses are cytotoxic.
Factors in the "antioxidant dilemma"
Liberation, Absorption, Distribution, Metabolism, Excretion
Category of phytochemicals with anti-microbial properties
capsiacin and dihydrocapsaicin are not water-soluble
Reason water doesn't cool your mouth after eating chilis.
Side effect shown in safety study of ingesting D-Limonene
Carotenoids in the process of oxidizing
Food with best overall bioavailability of lutein and zeaxanthin
It could prevent future damage
Reason for advising a patient with AMD to consume lutein-rich foods
It will not reverse damage
Reason for not advising a patient with AMD to consume lutein-rich foods