| Term | Definition |
|---|
| Base excision repair | use for abnormal base pairs like binding of a U with a G or a T with a C |
| Dna glycosylase | removes the base in base excision repair |
| pyrimidine dimer | A c and a t hooked together and use nucleotide excision repair |
| nucleotide excision repair mechanism | nuclease, dna helicase, dna polymerase, dna ligase |
| Repair of double stranded DNA breaks | 2 ways: homologous recombination (complete sequence restored) vs. non-homologous recombination where region is altered |
| Xeroderma pigmentosum | get from children being exposed to the sun at an early age |
| Defect of genome-wide nucleotide excision repair | xeroderma pigmentosum |
| cockayne syndrome | defect of scription coupled nucleotide excision repair, autosomall recessive |
| Ataxia-telangiectasia | caused by mutation in the ATM protein kinase |
| ATM protein kinase | signaling protein required for the repair of dna ds breaks |
| symptoms of ataxia-telangiectasia | sensitive to ionizing radiation, immunodeficienc, lymph malignancies, chromosome breakage |
| symtoms include poor growth, neuro problems, and early senility along with a defect in the nucleotide excision repair system | cockayne syndrome |
Combine with other sets
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