Immuno - MHC
Order by
17 terms
Terms | Definitions |
|---|---|
 allele | one of two genes present at a specific locus |
| CD4+ T cells | T cells whose role is cytokine secretion |
| CD8+ T cells | T cells whose role is cytotoxicity |
| class I MHC (major histocompatibility complex) | proteins present on all nucleated cells- antigenic fragments are displayed on the target cell surface within the protein groove |
| class I MHC restriction | refers to the fact that the antigen receptors on CD8+ T cells can only recognize antigenic fragments displayed in the groove of class I MHC proteins |
| class II MHC (major histocompatibility complex) | "proteins present on all APC; antigenic fragments are displayed within their groove, complex on cell surface" |
| class II MHC restriction | refers to the fact that the antigen receptors on CD4+ T cells can only recognize antigenic fragments when displayed with class II MHC on the surface of an antigen presenting cells |
| codominant expression | both alleles are expressed |
| costimulatory molecules | molecules that are required for activation of some cells |
| endosome | a vacuole that is formed within the cytosol |
| human leukocyte antigens (HLA) | in humans the MHC proteins may also be referred to as HLA proteins |
| invariant chain (Ii) | "a protein that is the same in all cells, blocks the class II MHC antigen binding site in the endoplasmic reticulum" |
| polymorphism | the occurrence of different forms of particular MHC proteins within a population |
| professional antigen presenting cell | cells whose primary role is to present antigen to T cells |
| proteasome | a complex of proteolytic enzymes that degrade cytosolic proteins to which ubiquitin has been attached proteins |
| transporter of antigen processing (TAP) | proteins to which peptides that have been degraded by the proteasome bind to enter the endoplasmic reticulum |
| beta 2 microglobulin | the invariant chain of the class I MHC cell surface protein |
First Time Here?
Welcome to Quizlet, a fun, free place to study. Try these flashcards, find others to study, or make your own.