Advertisement Upgrade to remove ads

Which of the following indices tells you whether the red cells are normochromic or hypochromic?
A. Red blood cell count (RBC)
B. Mean cell volume (MCV)
C. Hemoglobin
D. Hematocrit
E. Mean cell hemoglobin concentration (MCHC

E. Mean cell hemoglobin concentration (MCHC)

Which of the following indices tells you whether a patient's red cells are microcytic, normocytic, or macrocytic?
A. Mean cell hemoglobin concentration (MCHC)
B. Red blood cell count (RBC)
C. Hematocrit
D. Hemoglobin
E. Mean cell volume (MCV)

E. Mean cell volume (MCV)

Anisocytosis refers to:
A. Proliferation of red cells
B. Absence of red cells
C. Virtual absence of hemoglobin in red cells
D. Variation in red cell size
E. Variation in red cell shape

D. Variation in red cell size

An 18-year old, previously healthy male is rushed to the emergency room after a farming accident in which he suffered massive blood loss. A lab tech takes a sample of blood immediately upon the patient's arrival and rushes it back to the laboratory. Which of the following is true?
A. The hemoglobin will be normal
B. The MCV will be markedly increased
C. The RBC will be markedly decreased
D. The blood smear will show an increase in reticulocytes
E. The red cells will be hypochromic

A. The hemoglobin will be normal

Which type of anemia involves the attachment of IgG to red cells, which then get eaten up by macrophages in the spleen?
A. Anemia of chronic disease
B. Warm autoimmune hemolytic anemia
C. Cold autoimmune hemolytic anemia
D. Hereditary spherocytosis
E. Glucose-6-phosphate-dehydrogenase deficiency

B. Warm autoimmune hemolytic anemia

Which of the following lab results is consistent with a hemolytic process?
A. Decreased bilirubin
B. Decreased LDH
C. Decreased haptoglobin
D. Decreased reticulocytes

C. Decreased haptoglobin

Which type of anemia involves the attachment of IgM and complement to red cells?
A. Anemia of chronic disease
B. Warm autoimmune hemolytic anemia
C. Cold autoimmune hemolytic anemia
D. Hereditary spherocytosis
E. Glucose-6-phosphate-dehydrogenase deficiency

C. Cold autoimmune hemolytic anemia

The red cells in sickle cell disease are more susceptible to hemolysis because:
A. The red cell membrane is defective
B. They have less hemoglobin
C. They lack a cell-stabilizing enzyme
D. They are especially yummy to macrophages
E. They possess an abnormal hemoglobin which polymerizes upon deoxygenation

E. They possess an abnormal hemoglobin which polymerizes upon deoxygenation

Your 28-year-old, healthy sister was found to have a low hemoglobin when she tried to donate blood. Her doctor ordered a CBC, which showed the following:

Hgb 10 g/dL (12-16)
RBC 3.5 x 1012/L (4.5-6.0)
MCV 75 fL (80-100)
WBC 9.5 x 109/L (4-11)
RDW 15% (12 - 13.5)
Plt 400 x 109/L (150-450)

What is the most likely cause of your sister's anemia?
A. Thalassemia
B. Iron-deficiency anemia
C. Hereditary spherocytosis=
D. Aplastic anemia
E. Megaloblastic anemia

B. Iron-deficiency anemia

For many years, despite your grandmother's nagging, your grandfather has had a very poor and limited diet. He has developed numbness and weakness in his extremities. He reluctantly went to the doctor, and a blood smear showed a macrocytic anemia with hypersegmented neutrophils. Which of the following deficiencies is responsible for your grandfather's symptoms?
A. Iron
B. Vitamin K
C. Vitamin B12
D. Vitamin C
E. Vitamin D

C. Vitamin B12

One of your patients, a 65-year-old female, has been having progressively worsening fatigue and shortness of breath over the past few months. She also has had a few episodes of pneumonia, one of which landed her in the hospital, and she has diffuse petechiae scattered over her arms and neck. Her CBC shows the following:

Hgb 6 g/dL (12-16)
RBC 2.5 x 1012/L (4.5-6.0)
MCV 90 fL (80-100)
WBC 1.2 x 109/L (4-11)
RDW 13% (12 - 13.5)
Plt 20 x 109/L (150-450)

What is the most likely cause of your patient's anemia?
A. Iron-deficiency anemia
B. Anemia of chronic disease
C. Myelodysplastic syndrome
D. Aplastic anemia
E. Hereditary spherocytosis

D. Aplastic anemia

What is in a Heinz body?
A. Nuclear fragments
B. Rough endoplasmic reticulum
C. Iron
D. Denatured globin chains
E. Ketchup

D. Denatured globin chains

Malignancy, obstetric complications, sepsis and trauma can all cause which of the following findings on a blood smear?
A. Schistocytes
B. Oval macrocytes
C. Heinz bodies
D. Red blood cell agglutination
E. Sickle cells

A. Schistocytes

Which of the following is true regarding the immunophenotype of normal peripheral blood?
A. B cells and T cells are present in roughly the same proportion
B. B cells, T cells and NK cells are present in roughly the same proportion
C. Most of the lymphocytes are NK cells
D. Most of the lymphocytes are B cells
E. Most of the lymphocytes are T cells

E. Most of the lymphocytes are T cells

Which of the following blood findings is seen most commonly in infectious mononucleosis?
A. Mature lymphocytosis
B. Reactive lymphocytosis
C. Mature neutrophilia
D. Left shift
E. Leukoerythroblastotic reaction

B. Reactive lymphocytosis

Your patient has an elevated neutrophil count. The blood smear shows lots of unusual-looking neutrophils; some have abundant, dark-purple cytoplasmic granules, and others have lots of vacuoles in the cytoplasm. Which of the following disorders is the most likely cause of these findings?
A. E. coli sepsis
B. Lupus
C. Stress
D. Drug reaction
E. Mycosis fungoides/Sézary syndrome

A. E. coli sepsis

Your next patient has an elevated eosinophil count. Which of the following disorders is the most likely cause?
A. E. coli sepsis
B. Lupus
C. Stress
D. Drug reaction
E. Chronic myelofibrosis

D. Drug reaction

It's hard to believe, but your next patient has an elevated basophil count. She should be evaluated to see if she has:
A. E. coli sepsis
B. Lupus
C. Stress
D. Drug reaction
E. Chronic myeloid leukemia

E. Chronic myeloid leukemia

Which of the following is true of acute leukemia?
A. Symptoms come on slowly, over a period of months or years.
B. The bone marrow and blood are full of mature lymphoid or myeloid cells.
C. It almost never occurs in adults.
D. If a child gets acute leukemia, it is most often of the myeloid lineage.
E. It is rapidly fatal if not treated immediately

E. It is rapidly fatal if not treated immediately

All of the following statements about leukemia are true EXCEPT:
A. Acute leukemias typically present with sudden-onset bone marrow failure.
B. Acute leukemias are composed of blasts, and chronic leukemias are composed of maturing cells.
C. A T-cell immunophenotype is a poor prognostic indicator in acute lymphoblastic leukemia.
D. Acute lymphoblastic leukemia is most common in adults.
E. Chronic leukemias have a prognosis on the order of many years.

D. Acute lymphoblastic leukemia is most common in adults.

Patients with which of the following types of leukemia are at high risk for disseminated intravascular coagulation (DIC)?
A. Chronic myeloid leukemia
B. Chronic lymphocytic leukemia
C. Acute promyelocytic leukemia
D. Acute monoblastic leukemia
E. Acute erythroblastic leukemia

C. Acute promyelocytic leukemia

You are treating a patient who is undergoing therapy for acute leukemia. He has diffuse, massive gingival enlargement. Which of the following cell types does his leukemia most likely involve?
A. Neutrophil series
B. Monocytic series
C. Erythroid series
D. Megakaryocytic series
E. Basophilic series

B. Monocytic series

Auer rods may be seen in which of the following disorders?
A. Acute myeloid leukemia
B. Acute lymphoblastic leukemia
C. Chronic myeloid leukemia
D. Chronic myelofibrosis
E. Chronic lymphocytic leukemia

A. Acute myeloid leukemia

Which of the following disorders has a 20% cutoff for diagnosis?
A. Acute myeloid leukemia
B. Acute lymphoblastic leukemia
C. Chronic myeloid leukemia
D. Chronic lymphocytic leukemia
E. Polycythemia vera

A. Acute myeloid leukemia

Which of the following types of acute leukemia most frequently involves extramedullary sites?
A. Acute promyelocytic leukemia
B. Acute monoblastic leukemia
C. Acute erythroblastic leukemia
D. Acute megakaryoblastic leukemia
E. Acute lymphoblastic leukemia

B. Acute monoblastic leukemia

Which of the following is a good prognostic indicator in acute lymphoblastic leukemia?
A .T-cell immunophenotype
B. Age under 1 year
C. Age over 10 years
D. White blood cell count over 10,000
E. Hyperdiploidy

E. Hyperdiploidy

If a child gets leukemia, more often than not it is usually which kind?
A. Chronic myeloid leukemia
B. Chronic myelofibrosis
C. Chronic lymphocytic leukemia
D. Acute myeloid leukemia
E. Acute lymphoblastic leukemia

D. Acute myeloid leukemia
E. Acute lymphoblastic leukemia

Which of the following is true of chronic leukemia?
A. It can be myeloid or lymphoid
B. Symptoms usually come on suddenly, over a period of several days
C. It is just as common in children as it is in adults
D. The bone marrow and blood are full of blasts
E. It is rapidly fatal if not treated immediately

A. It can be myeloid or lymphoid

The Philadelphia chromosome is characteristic of which type of leukemia?
A. Acute myeloid leukemia
B. T-cell acute lymphoblastic leukemia
C. Chronic lymphocytic leukemia
D. Chronic myeloid leukemia
E. Polycythemia vera

D. Chronic myeloid leukemia

A healthy, 58-year-old male is found to have a mild lymphocytosis during a routine physical examination. All the lymphocytes appear small and mature, and immunophenotyping shows that they express both CD19 and CD5. What is the most likely diagnosis in this patient?
A. Benign, reactive lymphocytosis
B. Chronic lymphocytic leukemia/small lymphocytic lymphoma
C. B-cell acute lymphoblastic leukemia
D. T-cell acute lymphoblastic leukemia
E. Mycosis fungoides/ Sézary syndrome

B. Chronic lymphocytic leukemia/small lymphocytic lymphoma

A 60-year-old male has blood smear showing a marked neutrophilic leukocytosis with a left shift and basophilia. His marrow is hypercellular and composed predominantly of neutrophils and precursors. A cytogenetic assay of the neutrophils shows a translocation between chromosomes 9 and 22. Which of the following statements is true regarding his disease?
A. It has two phases
B. It is always rapidly progressive
C. It usually occurs in children
D. It may be benign
E. There is a new chemotherapy drug called imatinib (Gleevec) that has improved survival greatly in most patients with this disease

E. There is a new chemotherapy drug called imatinib (Gleevec) that has improved survival greatly in most patients with this disease

The four chronic myeloproliferative disorders:
A. Usually present with pancytopenia
B. May show splenomegaly
C. Occur just as often in children as they do in adults
D. Are indistinguishable from each other under the microscope
E. Are usually fatal within a period of months

B. May show splenomegaly

A 60-year-old woman presents with a huge spleen and fatigue. Her blood shows numerous teardrop-shaped red cells. Her bone marrow is fibrotic. What is the most likely diagnosis?
A. Acute myeloid leukemia
B. Infection
C. Sickle-cell anemia
D. Chronic myelofibrosis
E. Adenocarcinoma

D. Chronic myelofibrosis

Which of the following red cell indices tells you how big your patient's red cells are?
RBC
Hgb
MCV
RDW
MCHC

MCV

The RDW measures:
-The average concentration of hemoglobin in each red cell
-The total number of red cells
-The percentage of blood volume that is composed of red cells
-The variation in red cell size (all the same size vs. some big ones and some little ones)
-The height of the average Christian Louboutin heel

The variation in red cell size (all the same size vs. some big ones and some little ones)

"Chromasia" refers to:
-How big the red cells are
-How widely spaced the red cells are
-How much hemoglobin is in the red cells
-What color the red cells are
The age of the red cel

How much hemoglobin is in the red cells

A 40-year-old female says she feels tired all the time. On exam, you note that she is tachycardic and pale (she prefers the word "fair"). You order a CBC, which shows the following: Hgb 10 g/dL (12-16), MCV 75 (80-100). Which of the following is most likely?
-She has iron-deficiency anemia
-She has megaloblastic anemia, probably due to folate deficiency
-She has megaloblastic anemia, probably due to B12 deficiency
-She is not anemic, and her symptoms are probably caused by too little sleep and too many questions from Evans.

She has iron-deficiency anemia

A 60-year-old male has a hemoglobin of 9 g/dL. He also has the following lab results: MCV normal; LDH increased; haptoglobin decreased. Which of the following is most likely?
Iron-deficiency anemia
Megaloblastic anemia
Hemolytic anemia

Hemolytic anemia

You order a DAT, which comes back positive for complement, but not IgG?. What is the most likely diagnosis?
-Hereditary spherocytosis
-Warm autoimmune hemolytic anemia
-Cold autoimmune hemolytic anemia
-Any of a number of non-immune causes of hemolysis

Cold autoimmune hemolytic anemia

What causes the anemia in sickle cell disease?
-An inability of the red cell to reduce organic peroxides.
-An abnormal hemoglobin which polymerizes and irreversibly injures the red cell.
-Insufficient Hgb A and excess unpaired β, γ, and δ chains.
-Insufficient Hgb A and excess unpaired α chains.
-Consumption of red cells by splenic macrophages.

An abnormal hemoglobin which polymerizes and irreversibly injures the red cell.

A 32-year-old female presents for a routine physical. Her CBC shows the following: Hgb 9 g/dL(12-16), MCV 72 (80-100), RBC 6.4 (4.5-6.0), RDW 12.8% (12-13.5) . What is the most likely diagnosis?
-Iron-deficiency anemia
-Thalassemia
-Megaloblastic anemia
-Autoimmune hemolytic anemia
-Microangiopathic hemolytic anemia

Thalassemia

On a routine physical examination of an elderly male patient with no other medical problems, you note that his earlobes and fingertips are pale and slightly bluish. A CBC shows a hemoglobin of 10.6 g/dL (12 - 16) and an MCV of 88 (80 -100). Numerous red blood cell agglutinates are seen on the blood smear, made by smart technologists in your laboratory. Which of the following statements is true?
-The antibody bound to the patient's red blood cells in this disorder is probably IgG
-Complement is probably bound to the patient's red cells
-The spleen is the main site of red cell destruction in this patient
- a and c
- a, b and c

Complement is probably bound to the patient's red cells

Which of the following disorders may show the highest lymphocytosis,with lymphocyte counts as high as 100,000?
Bordetella pertussis (whooping cough)
Transient stress lymphocytosis
Infectious mononucleosis
Infectious lymphocytosis
Viral hepatitis

Infectious lymphocytosis

Of the following, which is the most useful in differentiating between chronic lymphocytic leukemia and a benign lymphocytosis due to infectious lymphocytosis?
Lymphocyte count
Lymphocyte morphology
Cytogenetic studies
TdT studies
Patient age

Patient age

Of the following, which is the most useful in differentiating between chronic myeloid leukemia and a benign neutrophilia with a left shift?
Neutrophil count
Neutrophil morphology
Cytogenetic studies
Myeloperoxidase staining
Patient age

Cytogenetic studies

Of the following types of acute myeloid leukemia, which is the most likely to present with skin and/or central nervous system involvement?
-Acute myeloblastic leukemia with maturation (AML-M2)
-Acute promyelocytic leukemia (AML-M3)
-Acute monoblastic leukemia (AML-M5)
-Acute erythroblastic leukemia (AML-M6)
-Acute megakaryoblastic leukemia (AML-M7)

Acute monoblastic leukemia (AML-M5)

Which of the following is a poor prognostic indicator in acute lymphoblastic leukemia?
-Age between 1 and 10
- T-cell immunophenotype
-White blood cell count less than 10,000 x 109/L
- hyperdiploidy

T-cell immunophenotype

Q3 Which of the following chromosomal alterations confers a poor prognosis?
11q23
t(8;21)
inv(16)
t(15;17)

11q23

Q4 Which of the following immunophenotypic patterns is consistent with B-cell ALL/Burkitt lymphoma?
CD19+, CD5+, TdT-
CD19-, CD5+, TdT+
CD19+, CD5-, TdT+
CD19+, CD5-, TdT-
CD19+, CD5-, TdT+

CD19+, CD5-, TdT-

What is the causative defect in sickle cell anemia?
A. abnormal spectrin
B. point mutation in a hemoglobin beta chain gene
C. lack of a detoxifying enzyme
D. deletion of one or more hemoglobin alpha chain genes
E. decreased number of erythroblasts in the bone marrow

B. point mutation in a hemoglobin beta chain gene

Please allow access to your computer’s microphone to use Voice Recording.

Having trouble? Click here for help.

We can’t access your microphone!

Click the icon above to update your browser permissions above and try again

Example:

Reload the page to try again!

Reload

Press Cmd-0 to reset your zoom

Press Ctrl-0 to reset your zoom

It looks like your browser might be zoomed in or out. Your browser needs to be zoomed to a normal size to record audio.

Please upgrade Flash or install Chrome
to use Voice Recording.

For more help, see our troubleshooting page.

Your microphone is muted

For help fixing this issue, see this FAQ.

Star this term

You can study starred terms together

NEW! Voice Recording

Create Set