← Neoplasia Test
5 Written Questions
5 Matching Questions
- What is the pathogenesis behind CML & ALL?
- In the japanese prostate & colon cancer are mostly attributed to what kind of influence?
- In familial & sporadic cases of retinoblastoma what must happen?
- What's the cause of melanoma?
- a Familial: spontaneous somatic mutation (2nd hit), 1st already occurred in germ line
Sporadic: 2 hits, both normal RB alleles must undergo somatic mutation
- b environmental (rate increased upon moving to U.S.)
- c Expansion of immature cells, with a corresponding decrease in the # & location of mature cells
Often indicative of an early metaplastic process
Typically used when the cellular abnormality is restricted to the originating tissue, as in the case of an early, in-situ neoplasm
- d AD mutation in p16/INK4A gene
- e t(9;22) leading to the BCR-ABL hybrid gene and tyrosine kinase activity promoting growth (APOPTOSIS IMPAIRED)
5 Multiple Choice Questions
- inherited p53 allele. AD, have a 25x greater chance of developing a malignant tumor by 50
- VEGF, bFGF
- serotonin, bradykinin
- level of differentiation
# of mitoses or architectural features
- how closely tumor cells resemble the corresponding normal parenchymal cells
5 True/False Questions
Differentiation/anaplasia of malignant tumors → some lack of differentiation with anaplasia; structure is often atypical
What are the breast cancer chemokine receptors? → prevents propagation of genetically damaged cells
What are some examples of metastasis by direct seeding of body cavities? → Direct seeding of body cavities or surfaces (transcoelemic)
syndrome of inappropriate ADH secretion- Causal mechanism → serotonin, bradykinin
In the japanese stomach cancer is influenced how? → genetically (rate stayed high for most of them regardless of moving to the U.S.)