Pharm-Exam 1 Study Guide
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26 terms
Terms | Definitions |
|---|---|
 Pharmacodynamics | Impact of the drugs on the body, determines nature and intensity of the response |
| Selectivity | Highly desirable characteristics; high selectivity= fewer side effects, Drugs act through receptors like a lock and key. |
| Pharmacokinetics | Study of drug movement throughout the body. MADE |
| Contraindication | makes a particular treatment or procedure undesirable |
| How does kidney disease effect pharmacokinetics? | Kidneys are the most important organ in the body for drug excretion |
| What is the Drug schedule from the Controlled Substances act of 1970 | Set of rules for the manufacturing and distribution of drugs considered to have potential for abuse. Schedule I- not accepted in the US and high potential for abuse, II-V have acceptable medical applications but still potential for abuse. Greater the # less chance for abuse. |
| "off-label" use | ... |
| Drug information resources to use | Pharmacist, Poison Control, PDR, Drug Facts |
| First-pass effect | Rapid hepatic inactivation of certain oral drugs |
| Half-life | Time required for the amount of drug in the body to decrease by 50%, Short-half life= leaves body quickly, Long-half life= leaves body slowly |
| Therapeutic index-what does this mean? | ... |
| Agonist | Molecules that activate receptors and mimic actions of the body's own regulatory system |
| Antagonist | Prevent activation of receptors and block the actions of endogenous regulatory molecules or blocking actions of drugs |
| Receptor binding does what? | ... |
| Grapefruit juice effect | Inhibits the metabolism of certain drugs raising blood levels |
| Anaphylaxis-when can it occur, how is it treated? | Severe allergy= hypotension, bronchoconstriction and edema of glottis=epinephrine injected IM |
| What does hepatotoxic mean? | ... |
| What are signs and symptoms of liver failure? | Jaundice, dark urine, light-colored stools, nausea, vomiting, malaise, abdominal discomfort, loss of appetite |
| What is an allergic reaction, how much of a drug does it take to cause an allergic rxn? | Immune response |
| When do you suspect an adverse drug reaction? | Unintended and undesirable effect that occurs at normal drug doses |
| What do you review before medication administration? | ... |
| Placebo effect | ... |
| Bioavailability | ... |
| Drug tolerance | ... |
| Accurate drug dosing is based on the patient's _________? | ... |
| Review cholinergic and adrenergic receptor location and functions | ... |
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