|Alpha receptor|| infinity order|
alpha goes from epinephrine to norepinephrine to isoprotonol
epinephrine has afinity for alpha receptors...it increases heart rate but BP stays same...alpha 1 receptors are in vessels and not in heart. Norepinephrine has more affinity for a2 receptors therefore BP increases.
|B receptor|| Beta goes from isoprotonol to epinephrine to norepinephrine|
Isoprotonol has high affinity for beta receptors therefore heartrate increases and BP decreases due to firing of CN 9/10
|epinephrine||1. get energy |
2. you try to increase blood sugar, insulin decrease and glucagon goes up
4. drug of choice for shock
5. local anesthetics
6. treatment for complete heartblock or cardiac arrest
7. bronchodilator for treatment of asthma
8. treatment for anaphalactic shock...
epinephrine can cause you to have arthymias, increase BP, hypergycemia, hyperlipidimia, aneurysm, and anxiety thoughts...
|nor-epinephrine||have prefe rnce fr alpha receptos....lungs have B2 receptors therefore nor-epi doesnt have that much effect on it. if you give atropine before you give norepinephrine your heart rate will go up... a1 and a2 agonist and some b1 activation...used to treat hypotention because causes vasoconstriction. HR decreases due to vagal-mediated central reflex, bp increases and total peripheral resistance increases.|
|isoproterenol||can be used for Asthma. B1, B2 agonist... bronchodilator for treatment of asthma...|
|Dopamine||its + inotroph and chronotroph...D2 receptors in renal vasculature- dopamine can be used for increase heart rate, contractile rate, and dilates vessels in kidney and in theory increase renal blood flow the best. D1 receptors in brain|
dopamine used for shock, heart failure and stress and for stress test but we usuallu use thalium....
drawback: high doses leads to vasoconstriction through alpha stimulation
|dolputamine||good ability to raise heart rate, bp normal, increase cardiac output without increasing oxygen demand on heart @ minimal increase on oxygen demand on heart|