Midterm: Immunoglobulins & Hypersensitivity
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Created by:
umdnjsnstudent on May 24, 2012
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Pathophysiology: A Clinical Approach (2nd Ed.); Braun.
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55 terms
Terms | Definitions |
|---|---|
 IgA | Protection of mucous membrane lined structures |
| IgA | Concentrated in bodily secretions such as breast milk, tears and saliva. |
| IgM | First immunoglobulin to proliferate in immune response |
| IgM | Bound to B lymphocytes and activates complement. |
| IgD | Bound to and activates B cell |
| IgE | Bound to mast cells in skin and mucous membranes |
| IgE | Stimulates mast cell release of histamine in allergic immune response, leading to inflammation |
| IgG | Most common circulating antibody |
| IgG | Activates complement (non-specific immune response) |
| IgG | Antibody (ab) activity against toxins, viruses and bacteria |
| IgG | Passive immunity in newborns via placental transfer |
| Hypersensitivity Type II | This hypersensitivity is an antibody mediated reaction (rxn) |
| Hypersensitivity Type II | IgG/IgM mediated |
| Hypersensitivity Type II | This hypersensitivity has a reaction (rxn) against normal "self" antigens and opsonization and lysis of cells |
| Hypersensitivity Type II | This hypersensitivity results from mistaken identity |
| Hypersensitivity Type II | This hypersensitivity results when a harmless substance identified as harmful |
| Hypersensitivity Type II | Reaction is tissue specific |
| Hypersensitivity Type II | Destruction of a target cell by antibody binding to antigen on the cell surface |
| Hypersensitivity Type II | This hypersensitivity is associated with blood transfusion reactions |
| Hypersensitivity Type II | This hypersensitivity is associated Graves disease and Hemolytic Disease of the Newborn |
| Hypersensitivity Type II | This hypersensitivity has saffected cells that are usually blood cells |
| Hypersensitivity Type II | This hypersensitivity results in cell lysis after antigen/Antibody binding |
| Hypersensitivity Type II | This hypersensitivity results in diseases such as anemia, thrombocytopenia, leukopenia |
| Hypersensitivity Type II | The treatment for this hypersensitivity is to remove the allergen |
| Hypersensitivity Type III | This hypersensitivity is immune complex mediated |
| Hypersensitivity Type III | This hypersensitivity is IgG and IgM mediated |
| Hypersensitivity Type III | This hypersensitivity has deposition of insoluble antigen-antibody complex in tissue |
| Hypersensitivity Type III | This hypersensitivity has indirect result of complement activation stimulated by the deposition of insoluble Ag/Ab complexes |
| Hypersensitivity Type III | This hypersensitivity reaction is first seen with individuals who received horse sera for treatment of tetanus |
| Hypersensitivity Type III | This hypersensitivity is associated with a condition called serum sickness |
| Hypersensitivity Type III | This hypersensitivity has a local reaction of fever and edema for 7 days after injection of horse sera caused by Ag/Ab deposit in tissue leading to complement activation and an inflammatory response |
| Hypersensitivity Type III | This hypersensitivity results in Arthus. Arthus is a reaction involving the formation of antigen/antibody complexes after intradermal injection of an antigen. If the person was previously sensitized (has circulating antibody). Localized tissue necrosis as a result of the complex mediated response |
| Hypersensitivity Type III | With this hypersensitivity subsequent exposure may lead to more severe reaction |
| Hypersensitivity Type III | This hypersensitivity is associated with a response causing Systemic Lupus Erythematosus (SLE) and Rheumatoid Arthritis |
| Hypersensitivity Type III | This hypersensitivity is occurs when there is little antibody and an excess of antigen, leading to small immune complexes being formed that do not fix complement and are not cleared from the circulation |
| Hypersensitivity Type IV | This hypersensitivity is associated with cell mediated hypersensitivity reaction. It is T-cell mediated; |
| Hypersensitivity Type IV | This hypersensitivity is associated with CD8 T lympho/CD4 lympho and an inflammatory response |
| Hypersensitivity Type IV | This hypersensitivity is T cell mediated not Antigen/Antibody mediated |
| Hypersensitivity Type IV | This hypersensitivity is associated with: • Direct cell-mediated toxicity • Delayed hypersensitivity reactions |
| Hypersensitivity Type IV | This hypersensitivity is associated direct cell-mediated toxicity |
| Hypersensitivity Type IV | This hypersensitivity is associated damage to cells and tissue as a direct response to CD 8 cytotoxic T lymphocytes destruction of cells with recognized antigens |
| Hypersensitivity Type IV | CD8 cytotoxic T lymphocytes attack all infected cells with recognized antigens whether antigen is harmful or not |
| Hypersensitivity Type IV | Response can be more harmful than the pathogen as in the case of hepatitis where the response of cell mediated toxicity is worse than the virus itself |
| Hypersensitivity Type IV | delayed hypersensitivity reactions |
| Hypersensitivity Type IV | Mediated by antigen-specific T lymphocyte |
| Hypersensitivity Type IV | Responds to antigen presented to them |
| Hypersensitivity Type IV | Often occurring on the skin/mediated by antigen-presenting cell (APC) and CD4 helper T cells |
| Hypersensitivity Type IV | Antigen usually small and can penetrate the skin causing itching. Antigen reacts with self proteins and create complexes that can bind to MHC molecules seen as foreign by T cells, stimulating an immune response |
| Hypersensitivity Type I | This hypersensitivity is associated with an immediate hypersensitivity |
| Hypersensitivity Type I | This hypersensitivity is IgE mediated |
| Hypersensitivity Type I | This hypersensitivity is associated with mast cells/basophils ( degranulate , release lipid products from cell membrane called leukotrienes and prostaglandin) helper Ts |
| Hypersensitivity Type I | This hypersensitivity is associated with local inflammation |
| Hypersensitivity Type I | This hypersensitivity is associated with systemic (anaphylaxis) and Pathophysiologic exaggeration of a defensive immune response |
| Hypersensitivity Type I | This hypersensitivity is associated with Anaphylaxis which is an extreme response, rxn/edema, vasodilation, hypotension |
| Anaphylaxis | extreme response to Type I hypersensitivity rxn/edema, vasodilation, hypotension |
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