PATHOLOGY UNIT 3 PART 1
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Created by:
AlexGriffin on October 5, 2009
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16 terms
Terms | Definitions |
|---|---|
 leukomoid | a marked leukocytosis, usually caused by inflamation |
| left shift | increased numbers of immature white cells in the peripheral blood |
| slight left shift | PMN and increased bands |
| moderate left shift | PMN, increased bands and metamyelocytes |
| marked left shift | bands, metamyelocytes, myelocytes, promyelocytes |
| regenerative left shift | increased WBC count (leukocytosis) and the presence of immature WBCs in the blood, mature cells still outnumber the immature cells, indicates an early response to increase in demand |
| degenerative left shift | normal or low white cell count with immature cells outnumbering mature cells, toxic changes are usually present, but this is not always the case, can indicate chronic condition and a prolonged response, the body is losing its ability to meet the increase demand, poor prognosis sign |
| dogs and cats cows and horses | __and__ can easily mount a slight or moderate left shift as they maintian a large pool of cells in the bone marrow maturation pool. __and__ however, have relatively small maturation pools. As a result, it is more likely that a leukopenia with slight left shift will occur. This should not be considered a degenerative left shift and is not an unfavorable prognostic indicator as it would be in other species. |
| toxic granulation | large, basophilic granules in neutrophils, indicate an increased demand, common in the dog |
| toxic vacuolation | neutrophil cytoplasm contains clear holes, moth eaten apearance, cytoplasm is basophilic indicating cytoplasmic immaturity |
| dohle bodies | light blue rod-shaped remnants of RNA, indicates cytoplasmic immaturity, common in cats |
| pelger-huet anomaly | a failure of the neutrophil nucleus to segment, looks like a band cell or a cell with two lobes at most, chromatin structure is condensed like in a mature PMN, may be an acquired or inherited condition |
| hypersegmentation | neutrophils with 5 or more lobes, may apear as a result of B-12 or folate deficiency |
| giant cells | very large, bizzare looking neutrophil and band cells, common in cats |
| auer rods | large red, rods seen in the cytoplasm of myeloblasts and monoblasts, never seen in lymphoblasts |
| the age of the animal, location of inflammatory process, virulence of organism | the magnitude of an inflammatory response depends upon |
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