Pharm Autonomic Drugs

56 terms by krompala 

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Bethanechol

Direct cholinomimetic. Postoperative and neurogenic ileus and urinary retention. Activates Bowel and Bladder. Resistent to AChE.

Carbachol

Direct cholinomimetic. Glaucoma, pupillary contraction, and release of intraocular pressure.

Pilocarpine

Direct cholinomimetic. Potent stimulator of sweat, tears, saliva. Pilo like pilus so acts anywhere hair grows (armpits, eyelashes, tongue?). Resistent to AChE.

Methacholine

Direct cholinomimetic. Challenge test for diagnosis of asthma

Neostigmine

Indirect cholinomimetic. Postoperative and neurogenic ileus and urinary retention, MG, reversal of NMJ blockage (post-op). Does not penetrate CNS

Pyridostimgine

Indirect cholinomimetic. MG (long acting); does not penetrate CNS

Edrophonium

Indirect cholinomimetic. Dx of MG (extremely short acting)

Physostigmine

Indirect cholinomimetic. Glaucoma (crosses BBB --> CNS) and atropine OD. Phys for Eyes.

Echothiophage

Indirect cholinomimetic. Glaucoma

Atropine

Muscarinic antagonist. Eye. (mydriasis and cycloplegia = paralysis of ciliary m. so no accomodation)

Homatropine

Muscarinic antagonist. Eye. (mydriasis and cycloplegia = paralysis of ciliary m. so no accomodation)

Tropicamide

Muscarinic antagonist. Eye. (mydriasis and cycloplegia = paralysis of ciliary m. so no accomodation)

Benztropine

Muscarinic antagonist. CNS (Parkinson's dz; PARK my BENZ)

Scopolamine

Muscarinic antagonist. CNS (motion sickness)

Ipratropium

Muscarinic antagonist. Respiratory (Asthma, COPD)

Oxybutynin

Muscarinic antagonist. GU (reduce urgency in mild cystitis and reduce bladder spasms)

Glycopyrrolate

Muscarinic antagonist. GU (reduce urgency in mild cystitis and reduce bladder spasms)

Methscopolamine

Muscarinic antagonist. GI (PUD)

Pirenzepine

Muscarinic antagonist. GI (PUD)

Propantheline

Muscarinic antagonist. GI (PUD)

Atropine and eye

INC pupil dilation, cycloplegia

Atropine and airway

DEC secretions

Atropine and stomach

DEC acid secretion

Atropine and gut

DEC motility

Atropine and bladder

DEC urgency in cystitis

Atropine OD

Sympathetics predominate with no PS balance: Hot as a hare, Dry as a bone, Red as a beet, Blind as a bat, Mad as a hatter

Atropine and possible complications

Angle-closure glaucoma (elderly), urinary retention (BPH), hyperthermia (infants)

Terbutaline

Beta2>beta1 direct agonist. Reduces premature uterine contractions (beta2 agonism reduces uterine tone)

Ritodrine

Beta2 direct agonist. Reduces premature uterine contractions.

Ephedrine

Indirect general agonist. Nasal decongestion, urinary incontinence, hypotension.

Alpha-methyldopa

Centrally acting Alpha-2 agonist. Decreased central adrenergic flow. HTN, esp with renal disease (no decrease in blood flow to kidney)

Selective beta2-agonists

Metaproterenol, albuterol, salmeterol, terbutaline

Mirtazapine

Depression. Tox: sedataion, increase serum cholesterol, inc appetite

Propranolol

Nonselective beta antagonist

Timolol

Nonselective beta antagonist

Nadolol

Nonselective beta antagonist

Pindolol

Nonselective beta antagonist

Labetalol

Nonselective beta antagonist

Sotalol

Nonselective beta antagonist; also K+ blocker (class III)

Acebutolol

beta1>2 antagonist (partial)

Betaxolol

beta1>2 antagonist

Esmolol

beta1>2 antagonist

Atenolol

beta1>2 antagonist

Metoprolol

beta1>2 antagonist

Carvedilol

nonselective beta blocker and alpha-1 blocker

Labetalol

nonselective beta blocker and alpha-1 blocker

Partial beta-agonists

Pindolol, acetutol

Name the direct cholinomimetics.

Bethanechol
Carbachol
Pilocarpine
Methacholine

Name the indirect cholinomimetics (anti-cholinesterases)

Neostigmine
Pyridostigmine
Edrophonium
Physostigmine
Echothiophate

Symptoms of organophosphate poisoning?

PS overload d/t irreversible inhibition of AChE
DUMBBELSS
Diarrhea
Urination
Miosis
Bronchospasm
Bradycardia
Excitation of skel musc and CNS
Lacrimation
Sweating
Salivation

Antidote for organosphosphate poisoning?

Atropine + Pralidoxime (regen of AChE)

Hexamethonium

Nicotinic antagonist. Ganglionic blocker. Prevents vagal reflex responses to changes in blood pressure. SE: orthostatic hypotension, blurred vision, constipation, sexual dysfunction.

Clonidine

Centrally acting alpha2-agonist. Decreased central adrenergic outflow.

alpha-methyldopa.

Centrally acting alpha2-agonist. Decreased central adrenergic outflow.

Name the alpha blockers

Phenoxybenzamine (nonselective)
Phenolamine (nonselective)
Prazosin (alpha1)
Terazosin (alpha1)
Doxazosin (alpha1)
Mirtazapine (alpha2)

Name the drugs that block alpha and bet

Carvedilol
Labetalol

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