PATH #21—Skin Cancer
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27 terms
Terms | Definitions |
|---|---|
 List 3 known etiologic factors for the development of skin cancers - carcinogens that alter cellular DNA | - UV light (also alters immune system) - ionizing radiation (x-rays) - chronic inflammation (leg ulcers, osteomyelitis sinus tracts - thermal burns (Marjolin ulcer) - HPV - arsenic - carcinogenic hydrocarbons |
| Actinic cheilitis - what - where -cause - describe | - lower lip - Solar (actinic) keratosis clinically and microscopically o Premalignant neoplasm of epidermis, can develop into invasive SCC o Cause: UV light o Scaly erythematous papules; perakeratosis, disordered maturation of keratinocytes (dyskeratosis) and solar elastosis in the dermis |
| Actinic cheilitis - what - location -cause - describe | - Solar (actinic) keratosis clinically and microscopically |
| Actinic cheilitis -cause | UV light |
| Actinic cheilitis - location | - lower lip |
| Actinic cheilitis - describe | Scaly erythematous papules; perakeratosis, disordered maturation of keratinocytes (dyskeratosis) and solar elastosis in the dermis |
| Basal cell carcinoma - relationship of epith component to stroma | dependent upon their stroma for growth and development |
| stroma | (fibrovascular CT) |
| • Most common type of human epith malignancy, 2x more frequent, develops de novo | Basal cell carcinoma |
| Basal cell carcinoma —describe clinically | Papule →ulcerates centrally, rolled border, translucent, telangiectasias |
| May invade widely and deeply but rarely metastasizes—BCC or SCC | BCC |
| Basal cell carcinoma —describe microscopically | Nests of basaloid cells (palisading) surrounded by fibrovascular stroma |
| Basal cell carcinoma —cause | Chronic solar damage and/or genetic predisposition |
| Malignant melanoma | - malignant neoplasm of melanocytes, begins in epidermis • >6mm, Asymmetrical, irregular borders, variation in color, ulceration (late) |
| "great mimicker", aypical melanocytes in epidermis | Malignant melanoma |
| Malignant melanoma—who? | - Sun exposure - fair complexion - heredity |
| Malignant melanoma- describe clinically | >6mm, Asymmetrical, irregular borders, variation in color, ulceration (late) |
| the difference (biologically) btw actinic keratosis arising on the lower lip and actinic keratosis arising elsewhere on the skin !!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!! | SCC that arise from Solar keratosis else where on the body rarely metastasize (2%) (locally aggressive) SCC from actinic keratoses on the lip >20 % develop metastatic disease !!!!!!!!!!!!!!!!!!!!!!!! !!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!! |
| Most common type of human epith malignancy !!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!! | BCC !!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!! |
| Skin cancer: Locally aggressive !!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!! | BCC !!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!! |
| Skin cancer: seldom metastasize !!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!! | BCC !!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!! |
| Who get Malignant melanoma and risk factors? !!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!! | - Sun exposure (lots of sun)BLISTERING SUN BURN @EARLY AGE - fair complexion (very fair skinned—so less likely blacks, hispanics and asians) - heredity (family history) !!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!! |
| >6mm - Asymmetrical - irregular borders - variation in color - ulceration (late) !!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!! | Malignant melanoma !!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!! |
| Skin cancer: No uniform color !!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!! | Malignant melanoma !!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!! |
| Skin cancer: No uniform outline !!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!! | Malignant melanoma !!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!! |
| Skin cancer: asymmetrical !!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!! | Malignant melanoma !!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!! |
| Lentigo maligna? | melanoma in situ on chronically sun damaged skin of the face |
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