5 Written questions
5 Matching questions
- Memory cells
- Ti antigen
- Affinity maturation
- a The increase in affinity of the antigen-binding sites of antibodies for antigen that occurs during the course of an adaptive immune response. Is a result of somatic hypermutation in the Ig.
- b General term for Lymphocytes that are responsible for immunological memory.
- c Complementary Determining Region. 3 types CDR1,2,3. Also known as Hypervariable, loops form the antigen binding site on Ig.
- d Thymus independent antigens. TI can elicit antibody production in the absence of t cells. TI-1 activates non-specific b cells. TI-2 have multiple identical epitopes that cross link b cell receptors.
- e Transporter Associated with antigen Processing. Degraded peptide fragments are transported into the ER through the dimerized TAP1 and TAP2.
5 Multiple choice questions
- Co-stimulator expressed on macrophages. Binds to CD40 ligand on TH1 cells to activate macrophage to destroy intracellular contents.
- Classical - C5 combines with C2a, C3b and C4b complex then activated (splits) into C5a and C5b
Alternative - binds with the Bb and 2 C3b complex then is activated into C5a and C5b
- The recognition of non self MHC molecules by T-cells.
- Immunoreceptor Tyrosine based Activation Motifs. These sequences allow the CD3 proteins to associate with cytosolic protein tyrosine kinases after receptor stimulation.
- The coating of the surface of a pathogen or other particle with any molecule that make it more readily ingested by phagocytes. This is done through antibodies and the complement system
5 True/False questions
Type II hypersensitivity → In Type II hypersensitivity, binding of a specific antibody directly to an antigen on the surface of a cell damages that cell either by cytolysis via the complement pathway or by destruction of cells by phagocytosis mediated by receptors for Fc or C3b.
Li chain → Light chain the smaller of the two types of polypeptide chains that make up Ig. Molecule one constant region and one variable region.
Neutralization by Ig's → involves the Ig binding tightly to the pathogen to prevent interaction with it receptor on humans. The Ig's crosslink pathogens. The neutralized pathogen once bound is phagocytosed.
Isotype → Natural variants of a protein that are encoded by the alleles of a given gene.
Function of APC cells → Are APC's. Involved in mediation of negative selection of T-cells, presenting processed epitopes via MHC ½, activation of naïve T-cells