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5 Written questions

5 Matching questions

  1. M cells
  2. Alloreactivity
  3. Anergy
  4. Memory cells
  5. B7
  1. a General term for Lymphocytes that are responsible for immunological memory.
  2. b Are specialized to transport microorganisms to gut associated lymphoid tissue. They take up by phagocytosis and endocytosis. Also known as Peyer's patch.
  3. c Are co-stimulatory molecules induced by the breakdown of bacteria by macrophages or other APC's. Are expressed on APC's surface it interacts with the CD28 receptor on t-cells for t cell recognition
  4. d The recognition of non self MHC molecules by T-cells.
  5. e When an immature B-cell binds soluble antigen, they are inactivated but not killed.

5 Multiple choice questions

  1. Derived from myeioid progenitor cells, Mast cells also secrete factors that attract and activate a special class of white blood cells called eosinophils which can kill certain types of parasites (eg intestinal worms) especially if the parasites are coated with IgE or lgA antibodies.
  2. In Type II hypersensitivity, binding of a specific antibody directly to an antigen on the surface of a cell damages that cell either by cytolysis via the complement pathway or by destruction of cells by phagocytosis mediated by receptors for Fc or C3b.
  3. NK cells are a subset of leucocytes capable of recognizing cell surface changes on virally-infected cells. NK cells bind to such infected cells and kill them. Also sometimes effective against transformed (tumor) cells.
  4. Thymus independent antigens. TI can elicit antibody production in the absence of t cells. TI-1 activates non-specific b cells. TI-2 have multiple identical epitopes that cross link b cell receptors.
  5. Areas in secondary lymphoid tissue that is a site of intense B-cell proliferation, maturation and death. They form around follicular dendritic cells.

5 True/False questions

  1. Fas ligandExpressed on TH1 cells, when bound to Fas receptor cell induces apoptosis of macrophage to release contents.

          

  2. OpsonisationThe coating of the surface of a pathogen or other particle with any molecule that make it more readily ingested by phagocytes. This is done through antibodies and the complement system

          

  3. Opsonisation by Ig'sinvolves the Ig binding tightly to the pathogen to prevent interaction with it receptor on humans. The Ig's crosslink pathogens. The neutralized pathogen once bound is phagocytosed.

          

  4. Clonal expansionProliferation of antigen triggered effector T-cells creating memory T-cells
    Clonal expansion of activated B-cells leading to differentiation of progeny into antibody secreting plasma cells.

          

  5. MHC restrictionThe coating of the surface of a pathogen or other particle with any molecule that make it more readily ingested by phagocytes. This is done through antibodies and the complement system

          

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