5 Written questions
5 Matching questions
- MHC restriction
- Function of APC cells
- a When T-cell recognizes both peptide and MHC molecule, occurs during positive selection of T-cell maturation causing the T-cell to lose one of its two co-receptors CD4 or CD8.
- b Found in the cytosol used to degrade cytosolic proteins. LMP gene encodes them is found in the MHC2 coding region. Two types, Proteasome 26s and 20s. They Contain a19s cap that prevents the entry of non-tagged proteins. Both 20s or 26s proteasomes can operate independently of the 19s cap
- c The classes of an immunoglobulins.
- d Cell surface glycoprotein on T-cells that recognizes MHC1 on APC's
- e Antigen presenting cell. Endocytose and degrade pathogen present via MHC 1/2 to activate b-cells and t-cells. After interaction with pathogen APC migrate to lymph nodes. Only cell to contain costimulators.
5 Multiple choice questions
- NK cells are a subset of leucocytes capable of recognizing cell surface changes on virally-infected cells. NK cells bind to such infected cells and kill them. Also sometimes effective against transformed (tumor) cells.
- Complementary Determining Region. 3 types CDR1,2,3. Also known as Hypervariable, loops form the antigen binding site on Ig.
- Lymphoid progenitor cells are the source of all Lymphocytes, they differentiate into T-cell, B-cells NK cells
Myeloid progenitor cells are the source of all other WBC, they become neutrophil, basophil, eosinophil, dendritic, macrophage, mast cells.
- Immature CD3,4,8 double positive thymocytes, Cortical epithelial cells, Negative selection for self reactive cells are eliminated.
- Immunoreceptor Tyrosine based Activation Motifs. These sequences allow the CD3 proteins to associate with cytosolic protein tyrosine kinases after receptor stimulation.
5 True/False questions
CD3 → Large signal transduction complex that is associated wit the T-cell receptor in the T-cell membrane. Contain Intracellular ITAMs domains.
Fab → Lymphocyte Function Associated Antigen-1. An integrin expressed by all t-cells it is important for to allow for binding to cell adhesion molecules expresses on extracellular matrix.
Adjuvant → Substances used in experimental immunology and in vaccines to enhance the adaptive immune response to an antigen. An adjuvant must be injected along with the antigen to have an effect. Most protein antigens are non-immunogenic without an adjuvant.
Components of C5 convertase → Classical - C5 combines with C2a, C3b and C4b complex then activated (splits) into C5a and C5b
Alternative - binds with the Bb and 2 C3b complex then is activated into C5a and C5b
Double negative thymocyte → The recognition of non self MHC molecules by T-cells.