5 Written Questions
5 Matching Questions
- Opsonisation by Ig's
- Mast cell
- Innate Immunity
- a Interleukin 2 is a cytokine that is produced by activated t cells it is essential for the proliferation of activated t cells and the development of an adaptive immune response
- b Second line of defence non-adaptive/non-specific immunity. Involve the non-specific destruction of pathogens via macrophages, neutrophils, NK cells and circulating proteins of complement and acute phase proteins.
- c Opsonisation is the coating of the pathogen with Ig molecules for their preparation and identification for phagocytosis. There is no cross linking of Ig's
- d Derived from myeioid progenitor cells, Mast cells also secrete factors that attract and activate a special class of white blood cells called eosinophils which can kill certain types of parasites (eg intestinal worms) especially if the parasites are coated with IgE or lgA antibodies.
- e The first stage in type 1 allergic response. Allergen in exposed to person. Processed and presented to t-cells. Il's produced which act on b-cells to produce IgE activating mast cells.
5 Multiple Choice Questions
- Co-stimulator expressed on macrophages. Binds to CD40 ligand on TH1 cells to activate macrophage to destroy intracellular contents.
- B cells in early development when they first express b cell marker proteins and it rearranges its heavy chain genes. D to J followed by V to DJ in late pro b phase.
- NK cells are a subset of leucocytes capable of recognizing cell surface changes on virally-infected cells. NK cells bind to such infected cells and kill them. Also sometimes effective against transformed (tumor) cells.
- The set of alleles carried on carried on a single chromosome. A person's haplotype is responsible for encoding MHC proteins.
- Are serine esterases present in the granules of a cytotoxic t cells and NK cells. On entering the cytosole of the target cell granzymes induce apoptosis of the target.
5 True/False Questions
CD3 → Large signal transduction complex that is associated wit the T-cell receptor in the T-cell membrane. Contain Intracellular ITAMs domains.
MHC restriction → The coating of the surface of a pathogen or other particle with any molecule that make it more readily ingested by phagocytes. This is done through antibodies and the complement system
Junctional diversity → Hypervariable regions 1 and 2 of VH and VL chains are encoded in the VH and VL gene segments. Hypervariable region 3 falls at the junction of V/J gene segments in light chains and is partially encoded in the D segment in heavy chains. In both diversity at HV3 is increased by the addition/deletion of additional nucleotides during the joining process involved in gene rearrangement. This gives "junctional diversity" a further source of diversity in H and L chain variable regions.
Alloreactivity → The recognition of non self MHC molecules by T-cells.
TAP → Transporter Associated with antigen Processing. Degraded peptide fragments are transported into the ER through the dimerized TAP1 and TAP2.