NAME: ________________________

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5 Written Questions

5 Matching Questions

  1. CD4
  2. Centroblast
  3. Components of C5 convertase
  4. IL4
  5. Isotype
  1. a Classical - C5 combines with C2a, C3b and C4b complex then activated (splits) into C5a and C5b
    Alternative - binds with the Bb and 2 C3b complex then is activated into C5a and C5b
  2. b The classes of an immunoglobulins.
  3. c 4 domain co-receptor expressed on the cytokine secreting TH1 cells, contains the binding site for MHC2 on activated antigen presenting B-cells and macrophages.
  4. d Cytokine secreted by TH1-cells to initiate proliferation and clonal expansion of B-cells.
  5. e Stimulated b-cells that are proliferating in the germinal centers.

5 Multiple Choice Questions

  1. involves the Ig binding tightly to the pathogen to prevent interaction with it receptor on humans. The Ig's crosslink pathogens. The neutralized pathogen once bound is phagocytosed.
  2. The recognition of non self MHC molecules by T-cells.
  3. Lymphocyte Function Associated Antigen-1. An integrin expressed by all t-cells it is important for to allow for binding to cell adhesion molecules expresses on extracellular matrix.
  4. The increase in affinity of the antigen-binding sites of antibodies for antigen that occurs during the course of an adaptive immune response. Is a result of somatic hypermutation in the Ig.
  5. Proliferation of antigen triggered effector T-cells creating memory T-cells
    Clonal expansion of activated B-cells leading to differentiation of progeny into antibody secreting plasma cells.

5 True/False Questions

  1. CD3Large signal transduction complex that is associated wit the T-cell receptor in the T-cell membrane. Contain Intracellular ITAMs domains.


  2. Isotype switchA given variable region can be expressed with any of the different constant regions through a mechanism known as isotype switching. Is dependent on circulating cytokines.


  3. Innate ImmunitySecond line of defence non-adaptive/non-specific immunity. Involve the non-specific destruction of pathogens via macrophages, neutrophils, NK cells and circulating proteins of complement and acute phase proteins.


  4. Fas ligandExpressed on TH1 cells, when bound to Fas receptor cell induces apoptosis of macrophage to release contents.


  5. Function of APC cellsHypervariable regions 1 and 2 of VH and VL chains are encoded in the VH and VL gene segments. Hypervariable region 3 falls at the junction of V/J gene segments in light chains and is partially encoded in the D segment in heavy chains. In both diversity at HV3 is increased by the addition/deletion of additional nucleotides during the joining process involved in gene rearrangement. This gives "junctional diversity" a further source of diversity in H and L chain variable regions.


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