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5 Written Questions

5 Matching Questions

  1. LFA1
  2. Allotype
  3. CD8
  4. Function of APC cells
  5. Main function of armed TH2 cells
  1. a Drive b-cells to differentiate and produce immunoglobulins of all other types. Also responsible for initiating B-cell responses by activating naïve B-cells to proliferate and secrete IgM. Leads to Humoral immunity.
  2. b Cell surface glycoprotein on T-cells that recognizes MHC1 on APC's
  3. c Natural variants of a protein that are encoded by the alleles of a given gene.
  4. d Lymphocyte Function Associated Antigen-1. An integrin expressed by all t-cells it is important for to allow for binding to cell adhesion molecules expresses on extracellular matrix.
  5. e Antigen presenting cell. Endocytose and degrade pathogen present via MHC 1/2 to activate b-cells and t-cells. After interaction with pathogen APC migrate to lymph nodes. Only cell to contain costimulators.

5 Multiple Choice Questions

  1. Classical - C5 combines with C2a, C3b and C4b complex then activated (splits) into C5a and C5b
    Alternative - binds with the Bb and 2 C3b complex then is activated into C5a and C5b
  2. Interleukin 2 is a cytokine that is produced by activated t cells it is essential for the proliferation of activated t cells and the development of an adaptive immune response
  3. The set of alleles carried on carried on a single chromosome. A person's haplotype is responsible for encoding MHC proteins.
  4. Immunoreceptor Tyrosine based Activation Motifs. These sequences allow the CD3 proteins to associate with cytosolic protein tyrosine kinases after receptor stimulation.
  5. The first stage of differentiation. The thymocytes do not have the CD3, CD4, CD8 or TCR surface markers that define t-cells.

5 True/False Questions

  1. OpsonisationExpressed on TH1 cells, when bound to Fas receptor cell induces apoptosis of macrophage to release contents.


  2. B7Are co-stimulatory molecules induced by the breakdown of bacteria by macrophages or other APC's. Are expressed on APC's surface it interacts with the CD28 receptor on t-cells for t cell recognition


  3. Isotype switchA given variable region can be expressed with any of the different constant regions through a mechanism known as isotype switching. Is dependent on circulating cytokines.


  4. AllergenAntigens that cause hypersensitive or allergic reactions, usually involving IgE antibody responses


  5. CD40Co-stimulator expressed on macrophages. Binds to CD40 ligand on TH1 cells to activate macrophage to destroy intracellular contents.


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