5 Written Questions
5 Matching Questions
- Function of APC cells
- Mast cell
- Neutralization by Ig's
- Affinity maturation
- a involves the Ig binding tightly to the pathogen to prevent interaction with it receptor on humans. The Ig's crosslink pathogens. The neutralized pathogen once bound is phagocytosed.
- b Derived from myeioid progenitor cells, Mast cells also secrete factors that attract and activate a special class of white blood cells called eosinophils which can kill certain types of parasites (eg intestinal worms) especially if the parasites are coated with IgE or lgA antibodies.
- c Antigen presenting cell. Endocytose and degrade pathogen present via MHC 1/2 to activate b-cells and t-cells. After interaction with pathogen APC migrate to lymph nodes. Only cell to contain costimulators.
- d The increase in affinity of the antigen-binding sites of antibodies for antigen that occurs during the course of an adaptive immune response. Is a result of somatic hypermutation in the Ig.
- e Found in the cytosol used to degrade cytosolic proteins. LMP gene encodes them is found in the MHC2 coding region. Two types, Proteasome 26s and 20s. They Contain a19s cap that prevents the entry of non-tagged proteins. Both 20s or 26s proteasomes can operate independently of the 19s cap
5 Multiple Choice Questions
- Antigens that cause hypersensitive or allergic reactions, usually involving IgE antibody responses
- When an immature B-cell binds soluble antigen, they are inactivated but not killed.
- Are specialized to transport microorganisms to gut associated lymphoid tissue. They take up by phagocytosis and endocytosis. Also known as Peyer's patch.
- A given variable region can be expressed with any of the different constant regions through a mechanism known as isotype switching. Is dependent on circulating cytokines.
- Are co-stimulatory molecules induced by the breakdown of bacteria by macrophages or other APC's. Are expressed on APC's surface it interacts with the CD28 receptor on t-cells for t cell recognition
5 True/False Questions
CD3 → Cell surface glycoprotein on T-cells that recognizes MHC1 on APC's
CD4 → Co-stimulator expressed on macrophages. Binds to CD40 ligand on TH1 cells to activate macrophage to destroy intracellular contents.
Li chain → Light chain the smaller of the two types of polypeptide chains that make up Ig. Molecule one constant region and one variable region.
TAP → Fragment with Antigen Binding specificity, Photolytic fragment of IgG that contain the antigen binding sites.
Allotype → The set of alleles carried on carried on a single chromosome. A person's haplotype is responsible for encoding MHC proteins.