5 Written questions
5 Matching questions
- Memory cells
- Innate Immunity
- NK cells
- a NK cells are a subset of leucocytes capable of recognizing cell surface changes on virally-infected cells. NK cells bind to such infected cells and kill them. Also sometimes effective against transformed (tumor) cells.
- b Second line of defence non-adaptive/non-specific immunity. Involve the non-specific destruction of pathogens via macrophages, neutrophils, NK cells and circulating proteins of complement and acute phase proteins.
- c 4 domain co-receptor expressed on the cytokine secreting TH1 cells, contains the binding site for MHC2 on activated antigen presenting B-cells and macrophages.
- d General term for Lymphocytes that are responsible for immunological memory.
- e The coating of the surface of a pathogen or other particle with any molecule that make it more readily ingested by phagocytes. This is done through antibodies and the complement system
5 Multiple choice questions
- The first stage of differentiation. The thymocytes do not have the CD3, CD4, CD8 or TCR surface markers that define t-cells.
- The set of alleles carried on carried on a single chromosome. A person's haplotype is responsible for encoding MHC proteins.
- When T-cell recognizes both peptide and MHC molecule, occurs during positive selection of T-cell maturation causing the T-cell to lose one of its two co-receptors CD4 or CD8.
- Transporter Associated with antigen Processing. Degraded peptide fragments are transported into the ER through the dimerized TAP1 and TAP2.
- Antigenic determinants or epitopes are specific regions of molecule that an antibody recognizes.
5 True/False questions
Granzymes → When an immature B-cell binds soluble antigen, they are inactivated but not killed.
Fas ligand → Substances used in experimental immunology and in vaccines to enhance the adaptive immune response to an antigen. An adjuvant must be injected along with the antigen to have an effect. Most protein antigens are non-immunogenic without an adjuvant.
Discontinuous epitope → The coating of the surface of a pathogen or other particle with any molecule that make it more readily ingested by phagocytes. This is done through antibodies and the complement system
Components of C5 convertase → Are proteolytic enzymes that are formed during complement activation to cleave C3 → In classical C4B and C2a. Alternative C3b and Bb, there by enabling covalently binding to antigens for targeting.
Function of dendritic cells → Antigen presenting cell. Endocytose and degrade pathogen present via MHC 1/2 to activate b-cells and t-cells. After interaction with pathogen APC migrate to lymph nodes. Only cell to contain costimulators.