5 Written questions
5 Matching questions
- MHC restriction
- Type I hypersensitivity
- Differentiate between lymphoid and myeloid progenitor cells
- a The classes of an immunoglobulins.
- b Antigenic determinants or epitopes are specific regions of molecule that an antibody recognizes.
- c When T-cell recognizes both peptide and MHC molecule, occurs during positive selection of T-cell maturation causing the T-cell to lose one of its two co-receptors CD4 or CD8.
- d Immediate type hypersensitivity response, antibody mediated IgE, soluble antigen, mast cell effector
- e Lymphoid progenitor cells are the source of all Lymphocytes, they differentiate into T-cell, B-cells NK cells
Myeloid progenitor cells are the source of all other WBC, they become neutrophil, basophil, eosinophil, dendritic, macrophage, mast cells.
5 Multiple choice questions
- Second line of defence non-adaptive/non-specific immunity. Involve the non-specific destruction of pathogens via macrophages, neutrophils, NK cells and circulating proteins of complement and acute phase proteins.
- Natural variants of a protein that are encoded by the alleles of a given gene.
- B cells in early development when they first express b cell marker proteins and it rearranges its heavy chain genes. D to J followed by V to DJ in late pro b phase.
- Fragment with Antigen Binding specificity, Photolytic fragment of IgG that contain the antigen binding sites.
- The first stage of differentiation. The thymocytes do not have the CD3, CD4, CD8 or TCR surface markers that define t-cells.
5 True/False questions
Opsonisation by Ig's → Opsonisation is the coating of the pathogen with Ig molecules for their preparation and identification for phagocytosis. There is no cross linking of Ig's
NK cells → Are specialized to transport microorganisms to gut associated lymphoid tissue. They take up by phagocytosis and endocytosis. Also known as Peyer's patch.
M cells → Are specialized to transport microorganisms to gut associated lymphoid tissue. They take up by phagocytosis and endocytosis. Also known as Peyer's patch.
Components of C5 convertase → Classical - C5 combines with C2a, C3b and C4b complex then activated (splits) into C5a and C5b
Alternative - binds with the Bb and 2 C3b complex then is activated into C5a and C5b
Allergen → Antigens that cause hypersensitive or allergic reactions, usually involving IgE antibody responses