5 Written Questions
5 Matching Questions
- Discontinuous epitope
- The components of C3 convertase
- a Found in the cytosol used to degrade cytosolic proteins. LMP gene encodes them is found in the MHC2 coding region. Two types, Proteasome 26s and 20s. They Contain a19s cap that prevents the entry of non-tagged proteins. Both 20s or 26s proteasomes can operate independently of the 19s cap
- b Are proteolytic enzymes that are formed during complement activation to cleave C3 → In classical C4B and C2a. Alternative C3b and Bb, there by enabling covalently binding to antigens for targeting.
- c Fragment with Antigen Binding specificity, Photolytic fragment of IgG that contain the antigen binding sites.
- d An epitope consisting of amino acids from different parts of the sequence, brought together by folding. Also known as Conformational epitope.
- e The set of alleles carried on carried on a single chromosome. A person's haplotype is responsible for encoding MHC proteins.
5 Multiple Choice Questions
- Natural variants of a protein that are encoded by the alleles of a given gene.
- Are APC's. Involved in mediation of negative selection of T-cells, presenting processed epitopes via MHC ½, activation of naïve T-cells
- Antigen presenting cell. Endocytose and degrade pathogen present via MHC 1/2 to activate b-cells and t-cells. After interaction with pathogen APC migrate to lymph nodes. Only cell to contain costimulators.
- Derived from myeioid progenitor cells, Mast cells also secrete factors that attract and activate a special class of white blood cells called eosinophils which can kill certain types of parasites (eg intestinal worms) especially if the parasites are coated with IgE or lgA antibodies.
- Areas in secondary lymphoid tissue that is a site of intense B-cell proliferation, maturation and death. They form around follicular dendritic cells.
5 True/False Questions
Opsonisation → The coating of the surface of a pathogen or other particle with any molecule that make it more readily ingested by phagocytes. This is done through antibodies and the complement system
CD8 → Complementary Determining Region. 3 types CDR1,2,3. Also known as Hypervariable, loops form the antigen binding site on Ig.
Components of C1 and their function are → Classical - C5 combines with C2a, C3b and C4b complex then activated (splits) into C5a and C5b
Alternative - binds with the Bb and 2 C3b complex then is activated into C5a and C5b
CD4 → 4 domain co-receptor expressed on the cytokine secreting TH1 cells, contains the binding site for MHC2 on activated antigen presenting B-cells and macrophages.
LFA1 → Lymphocyte Function Associated Antigen-1. An integrin expressed by all t-cells it is important for to allow for binding to cell adhesion molecules expresses on extracellular matrix.