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5 Written questions

5 Matching questions

  1. Epitope
  2. MHC restriction
  3. Type I hypersensitivity
  4. Differentiate between lymphoid and myeloid progenitor cells
  5. Isotype
  1. a The classes of an immunoglobulins.
  2. b Antigenic determinants or epitopes are specific regions of molecule that an antibody recognizes.
  3. c When T-cell recognizes both peptide and MHC molecule, occurs during positive selection of T-cell maturation causing the T-cell to lose one of its two co-receptors CD4 or CD8.
  4. d Immediate type hypersensitivity response, antibody mediated IgE, soluble antigen, mast cell effector
  5. e Lymphoid progenitor cells are the source of all Lymphocytes, they differentiate into T-cell, B-cells NK cells
    Myeloid progenitor cells are the source of all other WBC, they become neutrophil, basophil, eosinophil, dendritic, macrophage, mast cells.

5 Multiple choice questions

  1. Second line of defence non-adaptive/non-specific immunity. Involve the non-specific destruction of pathogens via macrophages, neutrophils, NK cells and circulating proteins of complement and acute phase proteins.
  2. Natural variants of a protein that are encoded by the alleles of a given gene.
  3. B cells in early development when they first express b cell marker proteins and it rearranges its heavy chain genes. D to J followed by V to DJ in late pro b phase.
  4. Fragment with Antigen Binding specificity, Photolytic fragment of IgG that contain the antigen binding sites.
  5. The first stage of differentiation. The thymocytes do not have the CD3, CD4, CD8 or TCR surface markers that define t-cells.

5 True/False questions

  1. Opsonisation by Ig'sOpsonisation is the coating of the pathogen with Ig molecules for their preparation and identification for phagocytosis. There is no cross linking of Ig's

          

  2. NK cellsAre specialized to transport microorganisms to gut associated lymphoid tissue. They take up by phagocytosis and endocytosis. Also known as Peyer's patch.

          

  3. M cellsAre specialized to transport microorganisms to gut associated lymphoid tissue. They take up by phagocytosis and endocytosis. Also known as Peyer's patch.

          

  4. Components of C5 convertaseClassical - C5 combines with C2a, C3b and C4b complex then activated (splits) into C5a and C5b
    Alternative - binds with the Bb and 2 C3b complex then is activated into C5a and C5b

          

  5. AllergenAntigens that cause hypersensitive or allergic reactions, usually involving IgE antibody responses

          

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