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5 Written questions

5 Matching questions

  1. Memory cells
  2. CDR
  3. Ti antigen
  4. Affinity maturation
  5. TAP
  1. a The increase in affinity of the antigen-binding sites of antibodies for antigen that occurs during the course of an adaptive immune response. Is a result of somatic hypermutation in the Ig.
  2. b General term for Lymphocytes that are responsible for immunological memory.
  3. c Complementary Determining Region. 3 types CDR1,2,3. Also known as Hypervariable, loops form the antigen binding site on Ig.
  4. d Thymus independent antigens. TI can elicit antibody production in the absence of t cells. TI-1 activates non-specific b cells. TI-2 have multiple identical epitopes that cross link b cell receptors.
  5. e Transporter Associated with antigen Processing. Degraded peptide fragments are transported into the ER through the dimerized TAP1 and TAP2.

5 Multiple choice questions

  1. Co-stimulator expressed on macrophages. Binds to CD40 ligand on TH1 cells to activate macrophage to destroy intracellular contents.
  2. Classical - C5 combines with C2a, C3b and C4b complex then activated (splits) into C5a and C5b
    Alternative - binds with the Bb and 2 C3b complex then is activated into C5a and C5b
  3. The recognition of non self MHC molecules by T-cells.
  4. Immunoreceptor Tyrosine based Activation Motifs. These sequences allow the CD3 proteins to associate with cytosolic protein tyrosine kinases after receptor stimulation.
  5. The coating of the surface of a pathogen or other particle with any molecule that make it more readily ingested by phagocytes. This is done through antibodies and the complement system

5 True/False questions

  1. Type II hypersensitivityIn Type II hypersensitivity, binding of a specific antibody directly to an antigen on the surface of a cell damages that cell either by cytolysis via the complement pathway or by destruction of cells by phagocytosis mediated by receptors for Fc or C3b.


  2. Li chainLight chain the smaller of the two types of polypeptide chains that make up Ig. Molecule one constant region and one variable region.


  3. Neutralization by Ig'sinvolves the Ig binding tightly to the pathogen to prevent interaction with it receptor on humans. The Ig's crosslink pathogens. The neutralized pathogen once bound is phagocytosed.


  4. IsotypeNatural variants of a protein that are encoded by the alleles of a given gene.


  5. Function of APC cellsAre APC's. Involved in mediation of negative selection of T-cells, presenting processed epitopes via MHC ½, activation of naïve T-cells


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