5 Written Questions
5 Matching Questions
- Function of APC cells
- Main function of armed TH2 cells
- a Drive b-cells to differentiate and produce immunoglobulins of all other types. Also responsible for initiating B-cell responses by activating naïve B-cells to proliferate and secrete IgM. Leads to Humoral immunity.
- b Cell surface glycoprotein on T-cells that recognizes MHC1 on APC's
- c Natural variants of a protein that are encoded by the alleles of a given gene.
- d Lymphocyte Function Associated Antigen-1. An integrin expressed by all t-cells it is important for to allow for binding to cell adhesion molecules expresses on extracellular matrix.
- e Antigen presenting cell. Endocytose and degrade pathogen present via MHC 1/2 to activate b-cells and t-cells. After interaction with pathogen APC migrate to lymph nodes. Only cell to contain costimulators.
5 Multiple Choice Questions
- Classical - C5 combines with C2a, C3b and C4b complex then activated (splits) into C5a and C5b
Alternative - binds with the Bb and 2 C3b complex then is activated into C5a and C5b
- Interleukin 2 is a cytokine that is produced by activated t cells it is essential for the proliferation of activated t cells and the development of an adaptive immune response
- The set of alleles carried on carried on a single chromosome. A person's haplotype is responsible for encoding MHC proteins.
- Immunoreceptor Tyrosine based Activation Motifs. These sequences allow the CD3 proteins to associate with cytosolic protein tyrosine kinases after receptor stimulation.
- The first stage of differentiation. The thymocytes do not have the CD3, CD4, CD8 or TCR surface markers that define t-cells.
5 True/False Questions
Opsonisation → Expressed on TH1 cells, when bound to Fas receptor cell induces apoptosis of macrophage to release contents.
B7 → Are co-stimulatory molecules induced by the breakdown of bacteria by macrophages or other APC's. Are expressed on APC's surface it interacts with the CD28 receptor on t-cells for t cell recognition
Isotype switch → A given variable region can be expressed with any of the different constant regions through a mechanism known as isotype switching. Is dependent on circulating cytokines.
Allergen → Antigens that cause hypersensitive or allergic reactions, usually involving IgE antibody responses
CD40 → Co-stimulator expressed on macrophages. Binds to CD40 ligand on TH1 cells to activate macrophage to destroy intracellular contents.