5 Written questions
5 Matching questions
- M cells
- Memory cells
- a General term for Lymphocytes that are responsible for immunological memory.
- b Are specialized to transport microorganisms to gut associated lymphoid tissue. They take up by phagocytosis and endocytosis. Also known as Peyer's patch.
- c Are co-stimulatory molecules induced by the breakdown of bacteria by macrophages or other APC's. Are expressed on APC's surface it interacts with the CD28 receptor on t-cells for t cell recognition
- d The recognition of non self MHC molecules by T-cells.
- e When an immature B-cell binds soluble antigen, they are inactivated but not killed.
5 Multiple choice questions
- Derived from myeioid progenitor cells, Mast cells also secrete factors that attract and activate a special class of white blood cells called eosinophils which can kill certain types of parasites (eg intestinal worms) especially if the parasites are coated with IgE or lgA antibodies.
- In Type II hypersensitivity, binding of a specific antibody directly to an antigen on the surface of a cell damages that cell either by cytolysis via the complement pathway or by destruction of cells by phagocytosis mediated by receptors for Fc or C3b.
- NK cells are a subset of leucocytes capable of recognizing cell surface changes on virally-infected cells. NK cells bind to such infected cells and kill them. Also sometimes effective against transformed (tumor) cells.
- Thymus independent antigens. TI can elicit antibody production in the absence of t cells. TI-1 activates non-specific b cells. TI-2 have multiple identical epitopes that cross link b cell receptors.
- Areas in secondary lymphoid tissue that is a site of intense B-cell proliferation, maturation and death. They form around follicular dendritic cells.
5 True/False questions
Fas ligand → Expressed on TH1 cells, when bound to Fas receptor cell induces apoptosis of macrophage to release contents.
Opsonisation → The coating of the surface of a pathogen or other particle with any molecule that make it more readily ingested by phagocytes. This is done through antibodies and the complement system
Opsonisation by Ig's → involves the Ig binding tightly to the pathogen to prevent interaction with it receptor on humans. The Ig's crosslink pathogens. The neutralized pathogen once bound is phagocytosed.
Clonal expansion → Proliferation of antigen triggered effector T-cells creating memory T-cells
Clonal expansion of activated B-cells leading to differentiation of progeny into antibody secreting plasma cells.
MHC restriction → The coating of the surface of a pathogen or other particle with any molecule that make it more readily ingested by phagocytes. This is done through antibodies and the complement system