Animal Viruses

Created by Dtpham 

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some class I, III, IV, V

Which classes of viruses can bring along there own RNA polymerase?

I, II, III

Which classes of viruses use Host Cell RNA Pol II?

Class I

Double-stranded DNA
(-) sense DNA used as mRNA template

Class II

Single Stranded DNA (-) or (+) sense
If (+) sense, dsDNA intermediate is made using Host cell DNA polymerase.
(-) sense DNA strand is used for mRNA template

Class III

Double-stranded RNA, (-) sense RNA strand is template for mRNA

Class IV

Single-stranded RNA, (+) sense, genome serves as mRNA

Class V

Single-stranded RNA, (-) sense, genome is template for mRNA

Class VI

Single-stranded RNA, (+) sense, genome needs to be converted into dsDNA and inserted into Host Genome. (-) sense strand of new DNA is then used as template.

CD155

What is the receptor for Poliovirus?

Sialic Acid

What is the receptor for influenza?

Direct entry

Only the genome is inserted into the cytoplasm

Receptor mediated endocytosis

Enveloped Viruses induces endocytosis. Lowered pH of Endosome results in the envelope of the virus from fusion with the Endosome Membrane.

Membrane Fusion

Virus the envelop fuses with host cell membrane, only capsid is inserted into the Cell

Non-structural Protein

Proteins that are made early

structural Protein

Proteins that are made later

Host Cell Polymerase

Most small Class I viruses use what for viral genome replication?

Virus Polymerase

Most large Class 1 Viruses use what for viral genome replication?

Host Cell RNA Pol II

Hepatitis B Virus use what for mRNA synthesis?

Virus Reverse Transcriptase

Hepatitis B Virus uses what for genome synthesis (dsDNA)?

Host Cell DNA Pol II

Class II Virus uses what for genome synthesis?

Animal Cells (Host) cannot make RNA use RNA template

Why do Class III, IV, V must bring their own RNA Pol or genes for RNA Pol, if they want to replicate their genome?

Icosahedral Capsids

Capsomer is packed as faces, and assembled into empty shell then genome insertion.

Helical Capsids

Capsomer is packed as lock washers, assembled around the genome.

Non-enveloped virus

Release is characterized by host cell lysis

Enveloped Virus, Budding

type of release where host nucleocapsid binding the Host cell membrane already equipped with the Env proteins.

Exocytosis

Type of Release where virus buds through an internal cell membrane. Golgi or ER. Travels to Cell membrane via vessicles.

Hepatitis B Virus

Virus that uses Exocytosis release

HIV, Influenza

Viruses that use Budding release

Poliovirus

Virus that uses Cell lysis for release

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