Immunology Life U. I've been told this info is good.

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In which of the following responses are T-cells involved?

Inflammation, Phagocytosis, Antibody mediated response. (all the above)

Increased concentration of ______ antibody indicate a parasitic infection

IgE

Serum Sickness can be caused by ______?

Bee venom, infection of antibiotics, injection of serum. (all the above)

antibodies (imuniglobulin) are _____ globulin proteins on the surface of B cells that react specifically with antigen.

Y (gamma)

Mechanisms for cell damage in type II hypersensitivity?

Classical complement cascade, natural killer cells, opsonization. (all of the above)

Incompatible blood transfusion could induce a hemolytic reaction that results in intravascular lysis of the RBC's and release of ______ from lysed cells?

Hemoglobin.

A fetus can produce immunoglobulins of which of the following classes?

IgM

Protein based antigens require help of special class of _____ to activate B cells

T Cells (T helper cells)

Which of the following componenets of complement is called anaphyatoxin?

C3a and C5a

C1 component of complement has a receptor for which of the following fragments of the immunoglobulin?

F-c

Which of the following components of the complement primary undergoes activation in the alternative complement pathway?

C3

Which of the following components of complement is the most important component that function as opsonin?

C3

T4 (helper) cells are able to recognize foreign antigens in combination with which of the following classes of the Major Histocompatibility Complex?

Class II molecules

B cells could be activated by an unprocessed antigen?

False (check on this one.)

Which of the following immunoglobulins is not able to activate the complement system by classic pathway?

IgE

In primary responses the antibodies of which of the following classes of immunoglobulins are detected first?

IgM

Both chains of antibody (H and L) are held together by?

Disulfide Bond

______ in both chain of antibody are responsible for antigen binding

V region

The human major histocompatibility complex (MHC) is composed of a cluster of genes located _______

Chromosome 6

The MHC is also known as?

Human leukocyte antigen (HLA)

Class II codes for molecules?

Complement component

A fetus is not able to produce IgG class immunoglobulins?

True

Which of the following is antigen presenting cell?

Macrophage

An antigen that occurs in various tissues of different species is referred to as?

Heterophillic antigen.

Deficiency in the early lectin and classical pathway components (C1,C2,C4) cause?

Type III hypersensitivity (immune complex disease) & Systemic lupus erythematosus (SLE). (B and C)

J chain is a glycopeptide chain associated with which of the following immunoglobulins?

IgA & IgM (A and C)

Properties of haptons include?

Reactivity but no immunogenicity

In primary response (during early state) most of the antibodies are the _____ type which is the first class antibody to be secreted by naive plasma cells, later the class of antibody is switched to _____

IgA --> IgD

Fab of antibody can clear the infection by?

Neutralize toxin & Opsonize microbe (A and B)

Auto antigen affect what?

Self tissue.

Which molecule is not stable?

C3

At which site does the antigen bind?

Variable

Trigger for memory B cells?

IgD

Function of secondary response?

IgG

What is the classic pathway?

C1 ----> C2, C4 -----> C3 -----> C5 to C9

Possible test question answer

Pollen

Mechanism for cell damage in type II hypersensitivity?

Classical complement cascade, Natural Killer cells, Opsonization. (all of the above)

The lack of immune response for self-antigens in the tissue is caused by:

Deletion of self reactive cells & Inactivating the cell (anergy). (A and B)

This tolerance is unresonsive to self-antigens (all the endogenous antigens)

Natural tolerance

Function of T suppressor cells is important in suppression? (lol)

True.

Antibodies against antibodies called?

Anti-idiotype antibody

In Graves' disease, antibodies blood, the TSH (Thyroid stimulating hormone) receptors on the thyroid gland. (? doesn't make sense to me)

True

Which of the following autoimune dieases is associated with butterfly rash on the face?

Systemic lupus (SLE, Red wolf)

Which of the following factors is/are involved in insulin dependent diabetes mellitus autoimmune diease?

Infection & HLA gene. (A and B)

Which of the following biochemical/s is/are going tobe reduced in Hashimoto's thyroiditis?

Thyroxin

Which of the following is called rheumatoid factor?

IgM-antibody against F-c portion of a patient's own IgG

Autoantibodies in double strained DNA are typical findings in which of the following disorders?

Systemic lupus erythematosus

Multiple sclerosis is associated with which of the following types of hypersensitivity reaction?

IV and III

The antibodies in warm agglutinin type immune hemolytic anemia consist of which of the following classes of immunoglobulins?

IgG

Allografts of lymphoid tissue are particularly immunogenic because of the high content of?

MHC class II expressing cells.

An example of a type III immune complex disease is?

Rheumatoid Arthritis (RA), (SLE), and sleroderma.. (one selection, not all of the above)

The localized reactions to injected antigens in the same body site such as booster shots are called?

Arthus reaction

A positive tuberculin skin test is an example of?

A delayed type allergy.

Contact dermatitis is caused by?

Chemical absorbed by the skin.

A graft transplanted between individuals who are members of different species?

Xenograft

Factors that affect the immune system and decrease the immune functions are as follows:

Chronic disease & Emotional Stress (A and C)

Patient with severe immunodeficiency disease in both T-cells and B-cells compartment accept a allogenic bone marrow graft (gotta love her grammar)

True

Natural antibodies have the following characteristics?

Low affinity, Low specificity, Harmless, Have some rule for clearing infection. (All of the above)

In natural tolerance 95% of apoptosis (PCD) of T cells found in:

Thymus

Central Tolerance is witin?

Thymus

Matching: See Back

1. Post Streptococal (Glomerulonephritis) = Immune complex disease (B)
2. Arthus reaction = Type III hypersensitivity (local) (C)
3. Serum Sickness = Type III hypersensitivity (systemic) (A)
4. Contact Hypersensitivity = Type IV (D)

T suppressor cells prevent ____ to make antibodies, and also precvent ____ from maturing into T-cytotoxic cells.

B cells, T cells

Preexisting infection can have positive or negative effects on immune response.

True

This is an induced tolerance in which an animal will fail to respond to non-self antigens (all exogenous antigens) from outside the body that would normally be immunologic.

Acquired Tolerance

Which of the following factors are involved in autoimmune disease?

Infection, Hormonal, Genetic, (all of the above)

These monkey antigens (Rh factor) are presented in ____ of humans and absent in the other ____

85/15 (%)

Transfusion reaction may cause?

Destruction of the tranfused cells by hemolysis opsonization, Increased phagocytosis (all of the above)

Which type of hypersensitivity is mediated by IgE?

Type I

Type III hypersensitivity is best described by which of the following statements?

It requires immune complex formation

All of the following are true about erythroblastosis fetalis EXCEPT

It is most severe during the first pregnancy.

An X-linked primary congenital humoral immunodeficiency is

Bruton's agammaglobulinemia

Death in a case of systemic anaphylaxis (type I) is usually due to

asphyxiation

Natural tolerance can be explained by

A. suppression
B. the clonal deletion theory
C. the clonal anergy theory (all of the above)

Tolerogens activate lymphocytes.

true

A blood transfusion reaction is an example of what type of hypersensitivity reaction?

type II

Products of the major histocompatability complex (MHC) mainly regulate the process of transplantation, immune responsiveness and aspects of complement synthesis.

true

Graft versus host disease occurs because of ___________ in the graft tissue.

T cells

An Arthus reaction is characteristic of which type of hypersensitivity reaction?

Type III

Increased susceptibility to fungal, viral and protozoan infections is associated with ____

T-cell deficiencies

In this mechanism of suppression the body makes antibodies against its own antibodies.

production of anti-idiotype antibodies

This theory to explain natural tolerance holds that cells with high affinity for self antigens are destroyed in the primary lymphoid organs.

clonal deletion

Which of the following is a graft between genetically different members of the same species.

allograft

Graft versus host reaction frequently develops following transplantation of

bone marrow

Tolerance to endogenous antigens is

natural tolerance

Which type of hypersensitivity is due to the presence of IgE?

Type I

Which type of hypersensitivity is due to T cell reactivity?

Type IV

The most common immunodeficiency disorder is

Selective IgA deficiency

Chediak-Higashi Syndrome is characterized by

a problem with phagocytosis

In this congenital disease the lymphocytes lack MHC markers

bare lymphocyte syndrome

Serum sickness from the administration of horse immunoglobulin results in
a systemic ____________ hypersensitivity reaction.

Type III

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