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Burkitt's Lymphoma
-Translocation?
-What gene?
-Histo morphology?
-Viral assocatin?

8;14
c-myc gene next to heavy-chain Ig

Starry-sky appearance
Sheets of lymphos + interspersed macrophages
EBV
Jaw lesion in endemic Africa

8;14

Burkitt's Lymphoma

Starry-sky appearance
Sheets of lymphos + interspersed macrophages
EBV
Jaw lesion in endemic Africa

Follicular lymphoma

'small cleaved-cell lymphoma'
14;18
bcl-2 - blocks apoptotis

WAXING + WANING LYMPHADENOPATHY

14;18

bcl-2
Follicular lymphoma = 'small cleaved-cell lymphoma'

WAXING + WANING LYMPHADENOPATHY

9;22

CML
Philadelphia chromosome
bcr-abl = tyrosine kinase = treat with imatinib

Myeloid stem cell = PMNs, basophils, etc.
Can accelerate and become ALL/AML

CML

9;22

Philadelphia chromosome
bcr-abl = tyrosine kinase = treat with imatinib

Myeloid stem cell = PMNs, basophils, etc.
Can accelerate and become ALL/AML

AML

Auer rods; DIC
15;17
all-trans retinoic acid (vitamin A)

15;17

AML
Auer rods; DIC
15;17
all-trans retinoic acid (vitamin A)

Mantle cell lymphoma

small UNcleaved cell lymphoma

11;14 - deactivation of bcl-1
CD5 - poor prognosis

11;14

Mantle cell lymphoma = small UNcleaved cell lymphoma

11;14 - deactivation of bcl-1
CD5 - poor prognosis

ALL
-Age?
-Markers?
-Triad of sx?
-Where can it spread?

YOUNG age
Can present with mediastinal mass in adults
Bone marrow replaced by lymphoblasts
TdT+ (marker of pre-T + pre-B cells)

IBA = infections (↓ WBC), bleeding (↓ platelets), anemia (↓ RBCs)

Can spread to CNS AND TESTES!

Hairy cell leukemia

Adults
MATURE B-cell tumor
TRAP+

(Don't confuse with smudge cell in CLL or reactive T-cell in EBV)

CLL

OLD people
Asymptomatic
SMUDGE cells
WARM hemolytic anemia (IgG)

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