Lymphomas + Leukemias
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Created by:
omarcomin51 Plus on June 10, 2012
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13 terms
Terms | Definitions |
|---|---|
 Burkitt's Lymphoma-Translocation? -What gene? -Histo morphology? -Viral assocatin? | 8;14 c-myc gene next to heavy-chain Ig Starry-sky appearance Sheets of lymphos + interspersed macrophages EBV Jaw lesion in endemic Africa |
| 8;14 | Burkitt's Lymphoma Starry-sky appearance Sheets of lymphos + interspersed macrophages EBV Jaw lesion in endemic Africa |
| Follicular lymphoma | 'small cleaved-cell lymphoma' 14;18 bcl-2 - blocks apoptotis WAXING + WANING LYMPHADENOPATHY |
| 14;18 | bcl-2 Follicular lymphoma = 'small cleaved-cell lymphoma' WAXING + WANING LYMPHADENOPATHY |
| 9;22 | CML Philadelphia chromosome bcr-abl = tyrosine kinase = treat with imatinib Myeloid stem cell = PMNs, basophils, etc. Can accelerate and become ALL/AML |
| CML | 9;22 Philadelphia chromosome bcr-abl = tyrosine kinase = treat with imatinib Myeloid stem cell = PMNs, basophils, etc. Can accelerate and become ALL/AML |
| AML | Auer rods; DIC 15;17 all-trans retinoic acid (vitamin A) |
| 15;17 | AML Auer rods; DIC 15;17 all-trans retinoic acid (vitamin A) |
| Mantle cell lymphoma | small UNcleaved cell lymphoma 11;14 - deactivation of bcl-1 CD5 - poor prognosis |
| 11;14 | Mantle cell lymphoma = small UNcleaved cell lymphoma 11;14 - deactivation of bcl-1 CD5 - poor prognosis |
| ALL -Age? -Markers? -Triad of sx? -Where can it spread? | YOUNG age Can present with mediastinal mass in adults Bone marrow replaced by lymphoblasts TdT+ (marker of pre-T + pre-B cells) IBA = infections (↓ WBC), bleeding (↓ platelets), anemia (↓ RBCs) Can spread to CNS AND TESTES! |
| Hairy cell leukemia | Adults MATURE B-cell tumor TRAP+ (Don't confuse with smudge cell in CLL or reactive T-cell in EBV) |
| CLL | OLD people Asymptomatic SMUDGE cells WARM hemolytic anemia (IgG) |
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