Ch 14 Lymphatic (Immune)

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Created by:

DrDavila Plus on June 20, 2012

Subjects:

BIO104: Human Anatomy & Physiology II

Description:

Dr Davila

Medical Careers Institute, ECPI University

Human Anatomy & Physiology II

BIO 104

Classes:

BIO104 DMW Term 6

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Ch 14 Lymphatic (Immune)

immune system function
1. produce lymphocytes, which provide immunity;
2. return lymph [interstitial fluid, or serum] and nutrients [eg, fat, electrolytes, etc.] to blood;
3. resist infection, or invasion of pathogens
4. remove and destroy cancerous cells and toxins
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immune system function 1. produce lymphocytes, which provide immunity;
2. return lymph [interstitial fluid, or serum] and nutrients [eg, fat, electrolytes, etc.] to blood;
3. resist infection, or invasion of pathogens
4. remove and destroy cancerous cells and toxins
pathogen microscopic organsims that cause disease;
eg, bacteria, viruses, fungi, parasites,
immunity ability to resist infection and disease
lymph watery fluid with leukocytes in lymphatic vessels;
♪ serum-like fluid originally ejected from capillaries, bathed over cells as interstitial fluid, and seeped into lymphatics, becoming lymph. Same Fluid, 3 places♪
interstitial fluid watery fluid between body cells;
blood serum ejected from capillaries becomes interstitial fluid
lymphatic vessels vessels that carry lymph under low-pressure;
similar to veins: thin wall, large lumen, valves;
carry lymph from tissue to lymph nodes, then return to blood;
aka lymphatics,
right lymphatic duct collects lymph from upper right quadrant of body; empties into right subclavian vein
thoracic duct collects lymph from remaining 3/4 of body: upper left quadrant and entire lower portion of body;
empties into the left subclavian vein;
aka left lymphatic duct,
lymph node encapsulated lymphatic organ located along lymph vessel;
filter lymph for pathogens and cancer;
lymphocytes may divide here [mitosis] causing swelling and firming;
3 superficial lymph nodes cervical, axillary, and inguinal lymph nodes;
palpated to assist in diagnosis
tonsils 3 pairs of non-encapsulated lymphatic tissue found in oral cavity;
palatine, adenoids, lingual;
"front-line" protection against pathogens entering body;
palatine tonsils pair of non-encapsulated lymphatic tissue found on both lateral sides of soft palate [posterior roof of mouth]
pharyngeal tonsils pair of non-encapsulated lymphatic tissue in nasopharynx;
aka adenoids
lingual tonsils pair of non-encapsulated lymphatic tissue found on posterior aspect of tongue;
requires a tongue depressor to view clearly
spleen largest lymphatic organ found in LUQ of abdomen;
filters old RBCs, and produces lymphocytes/monocytes: hence, it's pink;
in fetus, also produces RBCs
thymus lymphatic organ superior to heart [looks like hat on heart];
T-lymphocytes mature here
Peyer's patches patches of lymphatic tissue in the ileum of small intestine; protect body from ingested pathogens
natural immunity immunity not specific to particular disease, will block or attack any pathogen; cannot distinguish one attack from another;
eg, physical barriers (skin, mucus tears), fever, phagocytes, inflammation,
aka innate immunity,
acquired immunity immunity to a disease that is not innate but has been acquired during life;
formation of antibodies and lymphocytes after exposure to antigen;
can be active or passive AND naturally-acquired or induced
passive immunity receiving antibodies made by another organism;
eg, from mother or another animal for antivenom
active immunity organism actively makes its own antibodies;
eg, after illness or vaccination
naturally acquired active immunity organism makes its own antibodies after naturally falling ill
induced active immunity organism makes its own antibodies after receiving a vaccination or inoculation
naturally acquired passive immunity organism receives antibodies made by its mother, either in the womb through placenta, or through mother's milk
induced passive immunity receiving antibodies made by another animal, as in antivenom;
usually made in sheep, horse, or goat
immunization increasing resistance to infection by exposing body to inactivated pathogen and inducing active immunity
autoimmune disorder class of diseases in which the immune system targets normal body tissues and organs,
eg Type 1 diabetes, multiple sclerosis, lupus
allergy exaggerated or inappropriate immune response to an allergen;
aka hypersensitvity
allergen any antigen that may cause allergic response to occur; eg pollen, ant-bite venom
anaphylaxis life-threatening allergic reaction; symptoms include:
1. bronchoconstriction [causes difficulty breathing],
2. vasodilation [causes hives, decreased blood pressure, generalized edema];
may lead to circulatory collapse [of blood vessels];
lymphocyte 1 of 3 types of WBC (B-/T-/NK-lymphocyte)providing specific immunity (B & T) and some innate immunity (NK);
smallest WBCs;
25% of total WBC population
B lymphocyte differentiates in bone;
makes antibodies performing antibody-mediated immunity;
aka plasma cell
T lymphocyte differentiates in thymus;
performs cell-mediated immunity
NK cell type of lymphocyte performing a nonsppecific immunity called immunological surveillance;
kills viuses, other pathogens, and canerous cells
antigen any substance (toxin, cell-surface protein) that stimulates production of antibodies;
"anything body may see as foreign"
antibody immunoglobulin protein released by B-lymphocytes in response to antigen;
antibody sticks to antigen;
antibody signals phagocytic eosinophils
immunoglobulin class of proteins produced by B-lymphocytes, which function as antibodies;
5 types:
IgG most common
IgM "prototype" antibody
nonspecific defense block or attack any potential pathogen;
cannot distinguish one attack from another, so acts characteristically regardless
7 nonspecific defenses Physical barriers
Inflammation
Fever
Phagocytes
Immunological surveillance
Complement
Interferons
inflammation body tissue response to injury or irritation;
4 signs:
*swelling
pain
redness
heat*
blood borne infections blood-borne infections (ie HIV and Hepatitis C) require intimate contact with blood or other body fluids;
casual contact with hands, food, or sneezes cannot transmit these diseases

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