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ANY ROUND CELL WITH RATHER DENSE STAINING CYTOPLASM AND MINIMAL CYTOPLASM IN CONNECTIVE TISSUE, A BIT BIGGER THAN AN RBC,

LYMPHOCYTE

Antibody secretion

Plasma Cell

Killing infected cell

CD 8

Stimulate B lymphocyte, inflammation, activation of macrophages

CD4

FLT-3 ligand
TNF-a
TGFβ

Common lymphoid progenitor to small lymphocyte (which can turn into B lymphoctyte...need IL 1,2,4,6,7 to become a T lymphocyte).

Tpo= Thrombopoietin

Megakaryocyte to thrombocytes

Epo= erythropoietin

Erythrocyte

Granulocyte-macrophage colony-stimulating factor (GM-CSF)

Common myeloid progenitor to myeloblast to basophil, neutrophil, esoinophil, monocyte

IL 15

Natural Kill cell made in Bone Marrow

Flt 3L

Plasma Cell production in the bone marrow

IL 7

T cells made

Structure of T Cell Receptor

disulfide-linked heterodimer made up of an α and a β polypeptide chain, CD3 complex, zeta chain dimer

MHC Restriction

specificity of T cells for peptides displayed by the cell surgace MHC molecules

Aids T cell ratio

CD4 : CD8 is .5:1 instead of 2:1 ratio.

Signals needed for T Cell Activation

1. TCR + MHC & CD4/8 + MHC
2. CD 28 on T Cell + B7-1 (CD80)/ B7-2 (CD 86)

IL 2

T cells proliferate

What does CD 4 TH1 cell secrete?

IL 2 and IFN gamma. Activate macrophages and type IV hypersensitivity.

CD4 TH 2 cell secretion

IL 4, IL 5, IL 13. Type I hypersensitivy & Eosinophils

Ig alpha, Ig beta, IgM, IgD, CD 28

B cell receptor

CR2, CD 21

Type 2 complement receptor B lymphocyte, receptor for the Epstein- Barr Virus (Ebv readily infects B cells)

ANY CELL MIXED IN WITH LYMPHOCYTES BUT HAS A LARGER MORE "OPEN", LESS DENSE, LESS CIRCULAR NUCLEUS WITH MORE CYTOPLASM IS A

Macrophage

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