Pharm1 - Block3 - PNS general

53 terms by bigjohnshea45th

Create a new folder

Advertisement Upgrade to remove ads

Most of the viscera is controlled by both divisions of the _______

ANS (PNS and SNS)

PNS activity results in _______ heart rate
SNS activity results in _______ heart rate

reduced
increased

PNS has what effect on vision
SNS has what effect on vision

Miosis
Mydriasis

PNS has what result on GI motility
SNS has what result on GI motility

Increased
Decreased

PNS has what effect on urination
SNS has what effect on urination

Increased
Decreased

Example of an organ system only innervated by one component of the SNS

Vascular (by SNS only)

Example of an organ that relies on both PNS and SNS to function normally

Penis (PNS --> erection, SNS --> ejaculation)

When a system is dominantly innervated by one component of the ANS, if you block both components, what is the overall result

The outcome will appear as if only the dominant innervation had been blocked

(ex. is ganglionic blockers)

If an organ is dually innervated by the PNS and SNS, blocking one or the other will result in

The other becoming temporarily dominant

(ex. administration of atropine in an elderly male results in blocking the PNS and retention of urine in a man that otherwise may already have BPH, thus worsening the condition and prventing urination completely)

Effect of _________ on the eye:
Loss of accomodation
Loss of pupil constriction
Mydriasis

Atropine

Preganglionic SNS and PNS nerves both rely on what neurotransmitter

ACh

Postganglionic SNS nerves rely on what neurotransmitters

NE (mostly)
ACh

Postganglionic PNS nerves rely on what neurotransmitters

ACh

Drugs which interract with Nicotinic receptors, do so primarily at what location

Neuromuscular Junction
Adrenal Medulla
Autonomic Ganglia

The PNS Muscarinic receptors will be sensitive to what neurotransmitter

ACh

The SNS alpha and beta receptors will be sensitive to what neurotransmitters

NE
E

The SNS muscarinic receptors (ex. sweat glands) will be sensitive to what neurotransmitter

ACh

Preganglionic nerves of the SNS innervate the Adrenal Medulla with ACh released onto which receptors

Nictonic

The Adrenal Medulla maked which neurotransmitters for the SNS

NE : E
80% : 20%

Disease --> reduced NE w/ increased E from Adrenal Medulla

Pheochromocytoma

(reduced production of NE from E is a component of the disease)

Of the two components of the ANS, which is more widely distributed throughout the body

SNS

SNS plays no role in which intraoccular eye muslce

Ciliary muscle

(so no drug which interracts with SNS receptors will have any effect on accomodation of the eye)

Synthesizes Acetylcholine

Choline Acetyltransferase

Process of ACh release is by

Ca++ ions --> exocytosis

Inactivation of ACh in the neuromuscular junction

Acetylcholinesterase (ACh-ase)

Inhibition of ACh inactivation

ACh-ase inhibitors

Inactivation of ACh in locations other than neuromuscular junction

Butyryl Transferase

Butyryl Transferase is located in

Liver
Intestine
Plasma

ACh-ase hydrolyses ACh into Acetate and Choline, so that Choline may be

Reuptaken by presynaptic neuron and reused

Nicotinic muscular receptors are only in the neuromuscular junction, while Nicotinic Nerveous receptors are located where

Autonomic Ganglia
Adrenal Medulla

Nicotinic receptors are ligand gated cation channels for

Na+/K+

M1 receptors are located in which organs

Autonomic Ganglia
CNS

When M1 receptors open, what biochemistry results

^PLC --> ^IP3 and DAG --> ^Ca++ entry

M2 receptors are located in which organs

Heart, heart, heart

When M2 receptors open, what biochemistry results

dec Adenylyl Cylcase --> dec cAMP --> K+ channels open --> K+ exit

M3 receptors are located in which organs

Smoo Musc
Endothelium
Sweat/lacrimal glands

When M3 receptors open, what biochemistry results

^PLC --> ^IP3 and DAG --> ^Ca++ entry

Large dose of ACh applied to M2 in heart -->

Dec heart rate
Dec conduction

Low dose of ACh --> what impact on M3 receptors in vessles

Nitric Oxide release --> Vasodilation

Vasodilation --> what changes in heart function

Baroreceptor reflex --> ^ heart rate

Low dose of ACh --> M3 receptors in bronchus --> ?

Constriction
Increased secretion

Vasodilation is mediated by Nitric Oxide when arginine is transformed into NO via Nitric Oxide Synthase. NO is used as a substrate for Guanylyl Cyclase in smoo musc for what reaction

GTP --> cGMP

cGMP production in smoo musc results in

Smoo musc relaxation and vasodilation

Smoo musc relaxation and vasodilation results in decreased blood flow to heart and

reflex tachycardia

ACh in the GI agonizes which receptor

M3

ACh in GI on M3 -->?

^ tone and peristalsis
^ GI gland and lacrimal gland decretion
Sphincter relaxation

ACh in bladder agonizes which receptor

M3

ACh in bladder on M3 -->

Detrussor relaxation
Trigone and sphincter relaxation

Diarrhea and Micturation due to which neuro-trans in which locations

ACh in GI and bladder on M3

ACh in eye agonizes which receptor

M3

ACh in eye on M3 --> ?

Miosos
Accommodation (fixed near vision)

Accomodation (for near vision) occurs when

Ciliary muscle contracts --> zonule fibers relax --> lens bulges

Muscarinic blocker in eye on M3 -> ?

Mydriasis
Accommodation (fixed far vision)

Please allow access to your computer’s microphone to use Voice Recording.

Having trouble? Click here for help.

We can’t access your microphone!

Click the icon above to update your browser permissions above and try again

Example:

Reload the page to try again!

Reload

Press Cmd-0 to reset your zoom

Press Ctrl-0 to reset your zoom

It looks like your browser might be zoomed in or out. Your browser needs to be zoomed to a normal size to record audio.

Please upgrade Flash or install Chrome
to use Voice Recording.

For more help, see our troubleshooting page.

Your microphone is muted

For help fixing this issue, see this FAQ.

Star this term

You can study starred terms together

NEW! Voice Recording

Create Set