Advertisement Upgrade to remove ads

Thrombocytopenia

Decrease in platelets.

Nociceptive Pain

Result of activation of nociceptors pain fibers deep in cutaneous tissue.

Somatic Pain

Arises from bone joint or connective tissue; well localized gnawing sensation.

Visceral Pain

Result of nociceptor activation in thoracic or abdominal tissue; can be pancreas, liver, GI poorly localized... cramping.

Mass Screening

screen entire population (PKU)

Selective or Prescriptive Screening

high risk populations (BRCAI, sickle cell)

Single Screening

looking for defect or condition. (BP check)

Multiple Screening

2 or more defects or conditions; school vision and hearing.

Multiphasic Screening

screening over time; height, Denver Developmental Screening Test.

Prostate Screening

50 years

Cervical Screening

21 years of 3 years post inter

Morals

values or rules based on a clients conscience. Serve as guide to right/wrong behavior.

Ethics

From Greek word Ethos, means conduct, customs and character. A process of deciding best course of action when faced with conflict.

Data and Saftey Monitoring Board

Reports to IRB, monitors client safety in large clinical trials.

IRB

Institut. review board

Phase 1 Clinical Trials

Assist in developing safe drug levels and schedules of new drug using human subjects.

Phase 2 Clinical Trials

Usually focus of particular type of cancer, study safety and effect of drug on human body.

Phase 3 Clinical Trials

Compare new drug with standard therapy; usually large number of participants.

Phase 4 Clinical Trials

Long term safety and effectiveness; large number of participants needed.

Proto-Oncogenes

Genetic portion of DNA that regulates normal cell growth. Promote cell division

Tumor Supressor Genes

Genetic portion of DNA that stops, inhibits, or supersede cell division.

P53

Is most common mutated tumor suppressor gene.

failure of _________ may lead to malignancy.

Apoptosis

Oncogenes

Altered forms of normal proto-oncogenes. May give rise to cancers.

Signal Transduction

process of transmitting information received on the cell membrane to the cell's nucleus.

Overproduction of RAS oncogenes have been identified in what cancers?

Pancreatic, colorectal, lung, and thyroid.

Invasion

cells divide, increase bulk, and secrete enzymes. Invade surrounding tissues.

Angiogenesis

Ability of tumor to grow new blood vessels.

Metastasis

Spread of primary tumor to distant sites.

Inherited Cancers occur via...

carcinogenic mutation in germ cells. Account for 10% of cancer in the USA

Methotrexate

does not mix with ASA or NSAIDS; increases risk of methotrexate toxicity.

Combination therapies that include etoposide and alk. agents...

cause increase FSH levels and azoospermia or olgiospermia in 30-40% mals. Test funct. may be normal if tx with etoposide and nonalkylating agents (vincrustine, doxorubiein)

Extravasation

Warm Pack Plant Alkaloids. Cold- all other chemos

DIC

only lab increase in DIC is D-Dimer and FDP titers; everything else decrease.

SIADH

too much ADH mostly from pituitary gland.

ADH

causes water to be reabsorbed instead of excreted through the kidneys.

SIADH

fluid restriction

Severe SIADH

High concentrate sodium IVF

Sepsis

T=>100x4, P>90, Resp>20, WBC> 12,000

TLS

during cell kill. Give IVF

Lead time bias

cancer detected early but does not affect survival.

Pneumonectomy

whole lung removed

wedge recection

small wedge near lung surface

segmental resection

removal of 1 or more segments of lung

lobectomy

removal of lobe of lung

GCSF

granulocyte stimulating factor- stimulates myloid line; increases WBC's; starts 24 hours post chemo for 3-14 days.

Neulasta

long acting G-CSF

Infection

most common cause of death in person with cancer.

Very high Emetogenic

Cisplat, Cytoxan, Melphalan

High Emetogenic

Barbo, Cisplant, Etoposiac, Irinotecan, Oxaliplatin, Doxrubicin

Low Emetogenic

Vinoustine; age less than 50 risk for N+V (may have more anticiporty nausea)

Ibuprofen use caution in...

liver disease

Increased risk DIC

leukemia, lymphoma, buliany, breast, colon, gastric, lung, pancreatic, prostate, melanoma

Temozolomidic

delayed neutropenia

IL2

cytokine, based on the bodys own cytoxic response. Flu like symptoms, fever and chills.

Myclonus

jerking R/+ drg metabolites -->switch drug!

primary

diet exercise

secondary

prevention

oral mucusitis

oral cane. brush 90 seconds bid

Combination therapy

etoposide, cytoxin = azoospermia 30-40%post-pubertal men

Bleo

Anorexia+mucositis/esophagitis fever

Interferon, Interleukin + Vanc

Can produce a fever

90% of all bowel obstruction occur in...

the small intestine (think: small- can't get through!)

Vinoustine

pred- may need stool softeners

Pelvic Exentenation

removes all reproductive organs + adjacent tissues; involves colon, bladder, ureters, and other organs. Freq requires colostomy and urostomy.

Please allow access to your computer’s microphone to use Voice Recording.

Having trouble? Click here for help.

We can’t access your microphone!

Click the icon above to update your browser permissions above and try again

Example:

Reload the page to try again!

Reload

Press Cmd-0 to reset your zoom

Press Ctrl-0 to reset your zoom

It looks like your browser might be zoomed in or out. Your browser needs to be zoomed to a normal size to record audio.

Please upgrade Flash or install Chrome
to use Voice Recording.

For more help, see our troubleshooting page.

Your microphone is muted

For help fixing this issue, see this FAQ.

Star this term

You can study starred terms together

NEW! Voice Recording

Create Set