Ch 6 Virology DNA/RNA Viruses

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ah070  on July 1, 2012

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Microbiology

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Ch 6 Virology DNA/RNA Viruses

Hepadnavirus
inflammation of liver (hepatitus), jaundice; yellow skin, brown urine (due to blood)
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Hepadnavirus inflammation of liver (hepatitus), jaundice; yellow skin, brown urine (due to blood)
HAV Hepatitis A Virus fecal/oral means, no long term liver damage, no trmt, vaccine available
HBV Hepatitis B virus blood/body fluids transmission, long term liver damage; causes chronic liver disease or liver cancer. Concern for health care b/c can live in dried blood for up to 7 days; causes infection if comes in contact with broken skin.
HCV Hepatitis C virus transmission by blood exposure, blood transfusion (donor blood) = most common way of getting infection, risk of LT liver damage, no vaccine
HDV Hepatitis D virus transmission by exposure to blood or body fluids, requires co infection with Hep B, severe LT or permanent liver damage, usually seen with HIV patients
HEV Hepatitis E virus fecal/oral transmission, endemic-associated with poor hygiene/sanitation; in Central Asia, Middle East, parts of South America & Africa.
Herpes Virus group Group of 8 viruses, dormant stage (shows latency by reemerging) in human body, leads to relapse due to UV light (going to the beach), injury to area, fever, stress, immocompromised patient
HSV1 Herpses Simplex Virus 1 Location of infection = oral lesions in mouth, fever blisters,cold sores..90% of population infected, no treatment. Risk of herpetic whitlow --> health care worker who handles oral secretions with no gloves on fingers...lesions appear on fingers
HSV2 Herpes Simplex Virus 2 Location: gential; internal/external, thighs & buttocks. Characteristic symptom: lesions (blisters). Condoms dont protect, 20% of population infected.
EBV Epstein-Barr Virus mononucleosis; transmitted by saliva, 'kissing disease.' Charateristic symptom: sleepiness, 16-20 hoours; No trmt - self limiting; Heterophile antibodies found in blood, attacks myalin sheath of spical cord. Can lead to CFS (chronic fatigue syndrome), Burkitts Lymphoma(cancer of lymph nodes), MS (multiple sclerosis)
VZV Varicella-Zoster Virus Primary infection = Chicken Pox -- rash on face, scalp, trunk.
Re-emerges as: Shingles (>65 y.o. or cancer, HIV), Bells Palsy (temporarily paralyzed facial muscles).
Also: Reyes Syndrome possible w/aspirin: affect CNS - causes personality change, irritability, compativeness, confusion... or cause Death
HPV Human Papilloma Virus most common STD, causes gential warts and cancer. < 25 y.o. = 50%...by 50 y.o. = 80%. Treat c cryosurgery (freezing). Vaccine: Gardasil for 13-26 y.o., condoms do not prevent infection.
Parvovirus B19 5ths disease (5th in the line of red rashes); Characteristic symptom: slapped cheek appearence.
Complication in adults: extreme joint pain for several weeks; No trmt--self limiting.
Variola Virus Small Pox, lesions, unique rash: bb's under skin with dimple on top, last seen in 1977, used for bio terrorism c Native Americans.
HIV Human Immunodeficieny VirusType 1 and 2: Type 1 is more common. Cell infected: T-helper, diagnose c blood test--> c HIV screen, takes 1-3 mo to produce antibodies if + do a Western Blot to confirm.
Infection = AIDs; <200 CD-4 cells causes AIDS, virus converts RNA to DNA.
Treatment: Antiviral therapy to slow the progress of Aids, goal is to keep CD4 levels up, most common drugs: AZT aka "Hell in a Bottle" and Protease Inhibitors--enzyme to stop reverse transcriptase; use Combo drugs = "cocktail"
Can have HIV and not have AIDs (the disease part) for decades. HIV virus mutates many x/day and will mutate over a 100 million times by the end of the infection.
Polio Virus fecal/oral and fly transmission by contimated food/water, infects spinal cord (CNS); Vaccine: Salk injection & Sabin oral dose
Arboviruses athropod-borne virus, caused by vectors: ticks, fleas, mozquitoes & flies. Found in warm climates.
Yellow Fever Virus Mosquitos; Causes yellow fever; Characteristic symptom: jaundice, brown urine, plasma.
Vaccine available. Relevance to PA: 1793 the Capital of PA moved from Phili to Hbg due to an outbreak.
Dengue Fever Virus Mosquitos; Causes breakbone and blackwater fever, Characteristic symptom: severe pain in muscles & joints; black or red stool, jaundice.
WNV West Nile Virus Transmitted by mosquitos; Reservoirs = birds, horses or people; Causes West Nile Vile; Characteristic symptom = encephalitis; No vaccine.
Influenza Virus Type A H1N1- swine flue & H5N1- avian flue (bird flu)..H1N1 leads to pneumonnia and cause death; Complication = Gullian-Barre syndrome. No trmt-self limiting.
RSV Respiratory Synctial Virus viral resp disease in children,lead to lifelong asthma
RhinoVirus common cold, no abs destroy NF
Coronavirus SARS
Rubeola Virus severe measles infection, flat spread rash, Kopliks spots in mouth,spread respiratory
Rubella Virus mild form of measles, rash, unborn fetus
Mumps Virus salivary glands, replication of virus in other organs, big cheeks
Coxsackie Virus ulcers, lesions in mouth, rash on soles of feet and palms of hand,, very contigous
Rotavirus stomach flu in children, vomit and diah, fluid.electorye replacement
Norwalk/Norovirus stomach flu in adults, cruise ships, aerolization of vomit
Hantavirus mouse urine and dropping, mouse deer, Southwest Us, chest pain-death
Ebola Virus africa, hemorrgage fever-bleeding in every opening (DIC)
Rabies Virus saliva of animals, raccoons, salivation, lyssavirus, CNS effected
Prion Proteinaceous infectious particle brain, no nucleic acids compared to virus, control is to burn, kuru, scrapie, bovine encephlitis
Cancer causing viruses EBV HBV, HPV HTLV, virus turn genes on and off effection the immune system and other celluar process,
burkitts lyphoma, liver, cercical, leukemia

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