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A

A antigen on RBC surface and B antibody in plasma.

B

B antigen on RBC surface and A antibody in plasma

AB

A and B antigens on RBC surface; no antibodies in plasma; "universal recipient."

O

neither A nor B antigen on RBC surface; both antibodies in plasma; "universal donor"

Rh

Rh antigen on RBC surface. Rh-mother exposed to fetal Rh+ blood (often during delivery) may make anti-Rh IgG that can cross placenta during subsequent pregnancies and ause hemolytic disease of the newborn (erythroblastosis fetalis) in the next fetus that is Rh+. Treatment: Rho (D) immune globulin (rhogam) for the mother at first delivery to prevent future erythroblastosis

incompatible blood transfusions

incompatible blood transfusions can cause immunologic response, hemolysis, renal failure, shock, and death.
note: anti-AB antibodies-IgM (do not cross placenta); anti-Rh-IgG (cross placenta)

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