First Aid Pharm - Psych

42 terms by mmokran1 

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Social phobias

SSRI

Atypical depression

MAOI, SSRIs

Depression

SSRIs, SNRIs, TCAs

Bipolar

Lithium, valproic acid, carbamazapine

Depression with Insomnia

Trazodone, Mirtazapine

OCD

SSRIs, Chlomipramine

Anxiety

Benzodiazepines, Buspirone, SSRIs

Schizophrenia

Antipsychotics (have excess dopamine)

Tourettes

Antipsychotics (haloperidol, resperidone)

Antipsychotics MOA

D2 receptor blocking

Side effects

Neuroleptic malignant syndrome, Extrapyramidal symptoms, galactorhhea; muscarinic alpha and histamine blocking effects

Neuroleptic Malignant syndrome (NMS)

Rigidity, myoglobinuria, ANS instability, pyrexia

"FEVER" - Fever, Encephalopathy, Vitals unstable, Elevated enzymes, Rigidity of muscles

Treatment for NMS

Dantrolene or dopamine agonists (bromocriptine)

Evolution of Extrapyramidal symptoms

4 h acute dystonia, 4 d akinesia (Parksinsonian Sx), 4 wk akathisia (restlessness), 4 mo. tardive dyskinesia (caused by activation of the nigrostriatal pathway)

Low potency neuroleptics

Chlorpromazine (Corneal deposits), Thioridazine (reTinal deposits)

High potency neuroleptics

Haloperidol, trifluoperizine (more neurologic side effects)

Atypical antipsychotics

Block 5HT-2 and D2 receptors

Atypical antipsychotics mneumonic

Its ATYPICAL for OLd CLOZets to QUIETly RISPER from A to Z

(Olanzapine, Clozapine, Quietiapine, Risperidone, Aripiprazole, Ziprasidone)

Side effect of Clozapine

Agranulocytosis (weekly WBC monitoring), seizures

Use of atypical psychotics in schizophrenia

Treat positive and negative symptoms

Lithium MOA

Inhibit phosphoinositol cascade

Lithium side effects

(LMNOP) Movement (tremors), Nephrogenic diabetes insipidus, hypOthyroidism, Pregnancy problems

Buspirone

Stimulates 5HT-1A receptors. Used for anxiety. Not addictive

SSRI MOA

Block reuptake of serotonin

SSRI side effects

Serotonin syndrome with MAO-Is

Serotonin syndrome

Hyperthermia, muscle rigidity, cardiovascular collapse

Tricyclic antidepressants MOA

Block reuptake of NE and serotonin

TCA side effects

Sedation, anticholinergic

Toxicity of TCAs

"tri-C's" Convulsion, Coma, Cardiotoxicity

also hallucination in elderly
Rx: NaHCO3 for CV toxicity

Bupropion

Atypical Antidepressant and for smoking cessation; increased NE and Dopa; no sex SEs

SNRIs

-Venlafaxine, duloxetine
-MOA: inhibits NE > 5HT reuptake
-SE: increase BP

Mirtazapine

Antidepressent. Alpha2 antagonist, 5HT-2 and 5HT-3 antagonist.

Maprotiline

Antidepressant, NE reuptake blocker

Trazodone

- inhibits 5-HT reuptake
- treats insomnia
- SE: priapism "TrazoBONE"

MAO-I's MOA

Increase levels of amine NT's

Side effects of MAO-I's

Hypertensive crisis with Beta blockers and tyramine. Serotonin syndrome with SSRIs or meperidine.

Methylphenidate

Increase release of NE

Panic Disorder

SSRI, TCA, Benzodiazepines

Side effects of Ziprasidone

may prolong QT interval

Clinic use of Lithium

Mood stabilizer, blocks relapse and acute manic events. Also SIADH

Venlafaxine

SNRI - depression and GAD

Duloxetine

SNRI - depression and diabetic peripheral neuropathy

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