First Aid Pharm - Psych
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42 terms
Terms | Definitions |
|---|---|
 Social phobias | SSRI |
| Atypical depression | MAOI, SSRIs |
| Depression | SSRIs, SNRIs, TCAs |
| Bipolar | Lithium, valproic acid, carbamazapine |
| Depression with Insomnia | Trazodone, Mirtazapine |
| OCD | SSRIs, Chlomipramine |
| Anxiety | Benzodiazepines, Buspirone, SSRIs |
| Schizophrenia | Antipsychotics (have excess dopamine) |
| Tourettes | Antipsychotics (haloperidol, resperidone) |
| Antipsychotics MOA | D2 receptor blocking |
| Side effects | Neuroleptic malignant syndrome, Extrapyramidal symptoms, galactorhhea; muscarinic alpha and histamine blocking effects |
| Neuroleptic Malignant syndrome (NMS) | Rigidity, myoglobinuria, ANS instability, pyrexia "FEVER" - Fever, Encephalopathy, Vitals unstable, Elevated enzymes, Rigidity of muscles |
| Treatment for NMS | Dantrolene or dopamine agonists (bromocriptine) |
| Evolution of Extrapyramidal symptoms | 4 h acute dystonia, 4 d akinesia (Parksinsonian Sx), 4 wk akathisia (restlessness), 4 mo. tardive dyskinesia (caused by activation of the nigrostriatal pathway) |
| Low potency neuroleptics | Chlorpromazine (Corneal deposits), Thioridazine (reTinal deposits) |
| High potency neuroleptics | Haloperidol, trifluoperizine (more neurologic side effects) |
| Atypical antipsychotics | Block 5HT-2 and D2 receptors |
| Atypical antipsychotics mneumonic | Its ATYPICAL for OLd CLOZets to QUIETly RISPER from A to Z (Olanzapine, Clozapine, Quietiapine, Risperidone, Aripiprazole, Ziprasidone) |
| Side effect of Clozapine | Agranulocytosis (weekly WBC monitoring), seizures |
| Use of atypical psychotics in schizophrenia | Treat positive and negative symptoms |
| Lithium MOA | Inhibit phosphoinositol cascade |
| Lithium side effects | (LMNOP) Movement (tremors), Nephrogenic diabetes insipidus, hypOthyroidism, Pregnancy problems |
| Buspirone | Stimulates 5HT-1A receptors. Used for anxiety. Not addictive |
| SSRI MOA | Block reuptake of serotonin |
| SSRI side effects | Serotonin syndrome with MAO-Is |
| Serotonin syndrome | Hyperthermia, muscle rigidity, cardiovascular collapse |
| Tricyclic antidepressants MOA | Block reuptake of NE and serotonin |
| TCA side effects | Sedation, anticholinergic |
| Toxicity of TCAs | "tri-C's" Convulsion, Coma, Cardiotoxicity also hallucination in elderly Rx: NaHCO3 for CV toxicity |
| Bupropion | Atypical Antidepressant and for smoking cessation; increased NE and Dopa; no sex SEs |
| SNRIs | -Venlafaxine, duloxetine -MOA: inhibits NE > 5HT reuptake -SE: increase BP |
| Mirtazapine | Antidepressent. Alpha2 antagonist, 5HT-2 and 5HT-3 antagonist. |
| Maprotiline | Antidepressant, NE reuptake blocker |
| Trazodone | - inhibits 5-HT reuptake - treats insomnia - SE: priapism "TrazoBONE" |
| MAO-I's MOA | Increase levels of amine NT's |
| Side effects of MAO-I's | Hypertensive crisis with Beta blockers and tyramine. Serotonin syndrome with SSRIs or meperidine. |
| Methylphenidate | Increase release of NE |
| Panic Disorder | SSRI, TCA, Benzodiazepines |
| Side effects of Ziprasidone | may prolong QT interval |
| Clinic use of Lithium | Mood stabilizer, blocks relapse and acute manic events. Also SIADH |
| Venlafaxine | SNRI - depression and GAD |
| Duloxetine | SNRI - depression and diabetic peripheral neuropathy |
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