Specific Antidotes (First Aid)

25 terms by DrMexito 

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acetaminophen

N-acetylcysteine (regenerates glutathione) - also used to loosen mucus plugs in CF

salicylates

NaHCO3 (alkalinizes urine), dialysis

amphetamines

NH4Cl (acidifies urine)

anticholinesterase inhibitors, organophasphates

atropine, pralidoxime (regenerates AChE)

antimuscarinic, anticholinergic agents

phyostigmine (AChE inhibitor)

beta blocker

glucagon, calcium, atropine

digitalis

normalize, K, lidocaine (given to slow down HR), anti dig Fab, Mg2+

iron

deferoxamine

lead

CaEDTA, dimercaprol, succimer, penicillinames

mercury

dimercapol, succimer

copper

penicillinamine

gold

dimercaprol, succimer, penicillamine

arsenic

dimercaprol, succimer, penicillamine

arsenic poisoning = vomiting + garlic breath

cyanide

nitrite, hydroxycobalamin, thiosulfate

nitrites oxidize Hb to methoHb, which binds Cn; then thiosulfate binds, making it renally excretable

methemoglobin

methylene blue, vitamin C, cimetidine

carbon monoxide

100 percent O2

methanol

ethanol, fomepizole (inhibits alcohol dehydrongenase)

ethylene glycol

ethanol, fomepizole (inhibits alcohol dehydrongenase)

opioids

naltrexone, naloxone

benzodiazepines

flumenazil

TCAs

NaHCO3 (plasma alkalinization)

heparin

protamine sulfate

warfarin

vitamin K, fresh frozen plasma

tPA, streptokinase

aminocapronic acid

tPA and streptokinase are durgs that increase plasmin to bust up clots

theophylline

beta blocker

theophylline is a xanthine derivative that increases cAMP to decrease bronchoconstriction

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