Ross Vet Prep Medical Mathematics Toxicology Vocabulary

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SemiCharmedQuark  on July 8, 2012

Subjects:

ross, vet prep, medical mathematics, medical mathematics3, toxicology

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Ross Vet Prep Medical Mathematics Toxicology Vocabulary

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Ross Vet Prep Medical Mathematics Toxicology Vocabulary

Toxicology
The science of toxicants
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Terms

Definitions

Toxicology The science of toxicants
Xenobiotics Foreign chemicals that the body does not produce (a property of both drugs and toxicants)
Pharmacokinetic An alteration of absorption, distribution, biotransformation or excretion
Pharmacodynamic Two drugs act on the same receptors
Toxicant Any substance (solid liquid or gas) that when applied or introduced into the body may interfere with life processes or biological functions of the cells of the animal; a poison
Phytotoxin Plant Toxin
Mycotoxin Fungal Toxin
Zootoxin Animal Toxin
Toxin A poison from a biologic process ; a biotoxin
Toxic Used to describe the deleterious or undesirable effects of poisons
Therapeutic Used to describe the wanted or desirable effects of a drug
Toxicosis A disease caused by exposure to a poison; poisoning or intoxication
Toxicity The amount of a poison that under certain circumstances will cause toxic effects
Acute Toxicity The effect of a single dose or multiple doses during a 24 hour period
Subacute Toxicity Is the effect produced by daily exposure from one day to 30 days
Subchronic Toxicity Is the effect of exposure from 30 days to 90 says
Chronic Toxicity Is the effect produced by daily exposure for a period of 3 months or more
Chronicity Factor The ratio between acute LD 50 and chronic LD 50
Extremely Toxic 1 mg/kg or less
Highly Toxic > 1-50 mg/kg
Moderately Toxic > 50-500 mg/kg
Slightly Toxic > 0.5-5 g/kg
Practically nontoxic >5-15 g/kg
Relatively harmless > 15 g/kg
Toxic Dose A dose producing undesirable hemalogical, pathological or biochemical effects
The highest nontoxic dose (HNTD) The highest or largest dose which does not result in undesirable or toxic alterations (clinical, hematologic, biochemical, or pathologic alterations)
Maximum tolerated dose or minimum toxic dose (MTD) Similar to the HNTD
The toxic dose low (TDL) The lowest dose which produces toxic alterations and administering twice this dose will not cause death
LD0 The highest nonlethal toxic dose
The toxic dose high (TDH) The dose which produces toxic alterations and administering twice this dose will result in death
No-effect level (maximum nontoxic level) the amount of a chemical that can be ingested without causing any deaths, illness or toxic alterations in any of the animals for the stated period (usually 90 days to two years or more depending on the species)
The lethal dose the dose that causes death in any animal during the period of observation
LD50 The dose that kills 50% of the animals in a group
LD100 The lowest dose that kills all the animals in a group
Hazard (risk) Hazard is the danger from the possibility of exposure-how likely or unlikely it is
Toxicity Toxicity is the danger based on the amount of substance
Risk Factor The ratio between toxicity and use level. The higher the ratio, the less risk
Cumulative Toxicant A toxicant with a chronicity factor greater than 2.0

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