Pathogenic Properties of Viruses
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23 terms
Terms | Definitions |
|---|---|
 pathogen factors | strain of virus, inoculum size, target tissue, immunologic status of the host |
| most common entry for viruses | inhalation |
| requirements for replication (2) | viral receptors and machinery |
| spread of viruses (4) | blood, lymph, phagocytes, neurons |
| Viremia | viruses in the blood |
| endothelial lining replication | amplification of the infection, vasculitis, thrombosis(clots) DIC ischemia(lack of blood supply), hemorrhage, edema |
| Evasion of host defenses | intracellular, antigenic variation(genetic change) |
| outcomes of viral infections (4) | abortive, cell death (cytolytic) persistent |
| presistent infections | productive, latent, transforming |
| transforming | RNA DNA |
| acidic stain | eosin, acidophilic red |
| Basic stain | hematoxylin, basophilic blue |
| cytolytic (cytocidal=productive) changes | inhibition of dna, rna and protein synthesis, cytoskeleton, ADCC, membrane permeability, syncytia, chromosome change |
| ADCC | antibody dependent cell-mediated cytotoxicity cell with antigens + IgG+NK cell =death |
| syncytia | union of cells |
| oncogenic viruses | all intergrate their dna into host cell dna |
| DNA oncogenic viruse types | herpesviridae, adenoviridae, papillomaviridae, poxviridae, Hepadnaviridae |
| DNA oncogenic viruses | nonpermissive cells, p53 and Rb protein (brakes) |
| Provirus | ddDNA made from vRNA is intergrated into Host dna |
| RNA oncogenic viruses | retroviruses (accelerator) productive infection |
| 2 causes of cancer | 1. viral oncogenes in Provirus 2.promoters and enhancers |
| Characteristics of transformed cells | contined growth, cell morphology, cell growth rate, loss of contact inhibition( stacked compacted) chormosomal abnormalities |
| latent viral infections | periods of no activity |
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