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Which cells in the gastric mucosa produce intrinsic factor?

Parietal cells

Which nerve stimulates motility and secretions in the digestive system?

vagus nerve

Which enzyme breaks down protein into peptides?

trypsin

In which structure is oxygenated blood mixed with unoxygenated blood to support the functions of the structure?

liver

Why is an alkaline environment required in the duodenum?

Activation of intestinal and pancreatic enzymes

What is periodontitis?

Bacterial destruction of the attachments of teeth to the bone

Define achalasia.

Lack of a nerve plexus to relax the lower esophageal sphincter

What does esophageal atresia cause?

No fluid or food entering the stomach

What are common locations for oral cancer?

Floor of the mouth or tongue borders

What is a common cause of hiatal hernia?

Increased abdominal pressure

What are common signs of acute gastritis?

Vomiting with epigastric tenderness

What does the pathophysiology of chronic gastritis include?

the pathophysiology of chronic gastritis includes atrophy of the gastric mucosa with decreased secretions

Why does severe stress lead to peptic ulcer?

Reduced blood flow to the gastric wall and mucous glands, and reduced motility, leading to stasis of chyme and increasing glucocorticoid effects.

What would result from a perforated gastric ulcer?

Chemical peritonitis would result from a perforated gastric ulcer

What is often the first manifestation of a stress ulcer?

Hematemesis and hypotension

What does hematemesis indicate in an individual with peptic ulcer?

Erosion of large blood vessel

What would be a result of chronic bleeding from gastric carcinoma?

Occult blood in the stool and anemia

What is the most common location for peptic ulcers?

Proximal duodenum

What are some causes of gastric carcinoma?

Ingestion of smoked foods, genetic factors, ingestion of foods preserved with nitrates

How would hemolytic jaundice manifest itself?

Increased unconjugated bilirubin in the blood

Why does mild hyperbilirubinemia occur in newborns?

The immature liver cannot process bilirubin quickly

Define choledocholithiasis.

Obstruction of the biliary tract by gallstones

What are predisposing factors to cholelithiasis?

Bilirubin or cholesterol concentration in the bile

What is a major result of a gallstone obstructing the cystic duct?

Severe colicky pain in the upper right quadrant

Following a cholecystectomy, what happens to bile that is produced?

Small amounts of bile are continuously secreted and flow into the duodenum

How is Hepatitis A transmitted?

It is transmitted by the oral-fecal route

What is the most common type of hepatitis transmitted by blood transfusions?

Hepatitis C (HCV)

What condition is indicated if the hepatitis B antigen level remains high in the serum?

Chronic infection is present

Long term exposure to a hepatotoxin would result in what?

Gradual irreversible damage to the liver and cirrhosis

Why would encephalopathy result from cirrhosis?

Serum ammonia

Why is an increased tendency to bleed associated with cirrhosis?

Deficit of Vitamin K and prothrombin

What changes are seen in serum bilirubin in a patient with cirrhosis?

Increased conjugated and unconjugated bilirubin

What factors lead to ascites in patients with cirrhosis?

Increased aldosterone and deficit of albumin leads to ascites in patients with cirrhosis.

Why would serum ammonia increase in patients with cirrhosis?

Bleeding occurs in the digestive tract

What is the initial pathological change in alcoholic liver disease?

Accumulation of fat in hepatocytes with hepatomegaly

What are some causes of hepatic cancer?

Metastatic tumors, chronic hepatitis, and exposure to certain chemicals

Which types of hepatitis increase the risk of hepatocellular cancer?

Hepatitis B and Hepatitis C

What causes massive inflammation and necrosis in acute pancreatitis?

Activation and spread of proteolytic enzymes causes massive inflammation and necrosis in acute pancreatitis.

Why does chemical peritonitis and shock frequently result from acute pancreatitis?

Acute pancreatitis leads to inflammation and increased vascular permeability of the peritoneum, which affects fluid balance, leading to chemical peritonitis and shock.

Define steatorrhea.

Bulky, fatty, foul-smelling stools

Why may celiac disease cause malnutrition in children?

Damage to the intestinal villi

What are the dietary requirements for children with celiac disease?

Gluten-free

What are the typical changes occurring in the GI tract in Crohn's Disease?

Inflamed areas of the wall of the ileum alternating with thick fibrotic or normal areas

Why do fistulas form with Crohn's Disease?

Recurrent inflammation, necrosis, and fibrosis forms connections between intestinal loops

What do the stools of patients with ulcerative colitis look like?

Stools that are liquid with mucus, frank blood, and pus

Why does iron-deficiency anemia develop with ulcerative colitis?

Chronic blood loss in stools

What result would you see if the sigmoid colon was obstructed because of diverticulitis?

Small, hard stool

What kind of pain is typical with diverticulitis?

Lower left quadrant

What usually precipitates acute appendicitis?

Obstruction of the lumen of the appendix

What causes the localized pain and tenderness in the lower right quadrant in acute appendicitis?

Local inflammation of the parietal peritoneum

Why does localized peritonitis develop from acute appendicitis prior to rupture?

Intestinal bacteria escape through the necrotic appendiceal wall

Why does a volvulus cause localized gangrene in the intestine?

The mesenteric arteries are compressed in the twisted section of intestine

Why does hypovolemic shock develop with intestinal obstruction?

Vomiting and fluid shift into the intestine

What is the first change in arterial blood gases with diarrhea.

Decreased bicarbonate ion

Why does dehydration cause acidosis?

Hypovolemia and lactic acid production caused by dehydration leads to acidosis.

Why does dehydration limit compensation for acid-base imbalance that results from prolonged vomiting and diarrhea?

Hypovolemia limits renal function

Define melena.

Blood in a dark-colored stool

What occurs 2 to 3 hours after a meal in patients with dumping syndrome?

Hypoglycemia

Why do deficiencies if vitamins A, D, and K occur in patients with cirrhosis?

Decreased production of bile

What are some factors that lead to inflammatory bowel diseases?

Genetic and immunologic

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