| Term | Definition |
|---|
| Methotrexate | folate antagonists--inhibits DHFR; (DNA synthesis inhibitor) causes myelosuppression at 4-7 days, mucositis, acute renal failure; can save pt with leucocorin |
| thioguanine | purine antagonist--inhibits PRPP (DNA synthesis inhibitor); general side effects |
| fludarabine | purine antagonist (DNA synthesis inhiibitor) |
| 5-Fluorouracil | pyrimidine antagonist (DNA synthesis inhiibitor); BMS, mucositis, hand-foot syndrome, cardiac symptoms, can save pt with leucovorin |
| gemcitabine | pyrimidine antagonist (DNA synthesis inhiibitor) |
| hydroxyurea | ribonucleotide reductase inhibitor (DNA synthesis inhiibitor); teratogenic |
| cisplatin | platinum compound (DNA alkylating drug), very nephrotoxic |
| carmustine | nitrosurea drug (DNA alkylating drug) |
| mechlorethamine hydrochloride | nitrogen mustard (DNA alkylating drug) |
| cyclophosphamide | nitrogen mustard (DNA alkylating drug) |
| topotecan | Topoisomerase I antagonist (Topo inhibitor) |
| etoposide | Topoisomerase II antagonist (Topo inhibitor) |
| Doxorubicin | DNA intercalating drug |
| vincristine | tubulin polymerization inhibitor (mitotic inhibitors); neurotoxic |
| paclitaxel | tubulin depolymerization inhibitor (mitotic inhibitors); neurotoxic and common hypersensitivity |
| rituximab | anti CD20 (monoclonal antibody) |
| Trastuzumab | anti HER2/neu (monoclonal antibody) |
| Bevacizumab | anti VEGF (monoclonal antibody) |
| panitumumab | anti EGF receptor (monoclonal antibody) |
| imatinib | Bcr-abl (tyrosine kinase inhibitor) |
| erlotinib | EGF receptor (tyrosine kinase inhibitor) |
| Bortezomib | 26S proteasome inhibitor; neuropathies, infusion reactions |
| alpha 2a and 2b | recombinant interferons (immunomodulators); flu-like symptoms, fatigue, confusion |
| IL-2 | cytokine (immunomodulators) |
| G-CSF | cytokine (immunomodulators) |
| GM-CSF | cytokine (immunomodulators) |
| prednisone | glucocorticoids (hormones) |
| tamoxifen | antiestrogens (hormones); menopause-like symptoms and masculinization |
| flutamide | antiandrogens (hormones); hot flashes, gynecomastia, nipple pain, galactorrhea, impotence, feminization |
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