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5 Written questions

5 Matching questions

  1. Tx of DM 1
  2. aMSH absent
  3. Hypophysiotropic neurohormones
  4. Glucagon like peptide-1 (GLP-1)
  5. Negative feedback
  1. a neurohorms produced by neurosecratory neurons of hypothalamus that regulate release of AP horms
  2. b dec in cAMP increase free Ca2+ causing contraction of melanofilaments whic hpull melanosomes into smaller area, causing lightened skin
  3. c intestinal peptide encoded in proglucagon gene; produced by L cells of the intestine; stimulates insulin release in presence of glucose and suppresses glucagon secretion
  4. d insulin replacement; monitor BSG levels; B cell transplant; insertion fo insulin gene in other cell types
  5. e Hypothalamus releases CRH to AP, stimulates ACTH release

5 Multiple choice questions

  1. Genotropsin ex of hGH, excess GH long acting analogs of SST
  2. stimulates lipolysis in fat cells, source of endorphins such as B endorphins
  3. increase glucose uptake indirectly by stimulating glucokinase which inhibits glucose-6 phosphate; inc glucose storage by stimulating glucose sythetase; inc lipid sythesis by stimulating triglyceride sythetase
  4. Juvenile onset, insulin dependent; lack of insulin; requires insulin replacement; 20% of cases, most serious; 90% childhood cases; mortality 10x nl
  5. Inc eating duet o cellular starvation

5 True/False questions

  1. Hyperglycemiapanhypopituitarism - total loss of secretion


  2. Eating too little effectHypothalamus releases CRH to AP, stimulates ACTH release


  3. Secretin familySecretin, glucagon, gastric inhibitory peptide (GIP), vasoactive intestinal peptide (VIP); share AA sequences; inc cAMP


  4. aMSH cleared from ACTH sections of POMCincrease Ca mobilization from bone; stimulate osteoblasts to release osteoclast diff inducing factore (IL-6) that cause osteoclasts to release acid proteases whichd digest bone matrix; stimulates differentiation of precursor cells to osteoclasts


  5. Category 3 horm's (ACTH, aMSH, BLPH)derived from pro-opiomelanocortin (POMC)


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