| Term | Definition |
|---|
| What organ do hepadnaviruses affect? | Liver |
| Three particles produced by Hepadnaviruses? | infectious ( enveloped icosahedral), then two noninfectious decoys (spherical, filament) |
| Hepadnavirus is the _____ enveloped virus of human viruses. | smallest |
| Genome of hepadnavirus? | circular dsDNA with ss gap |
| minus strand of hepadnavirus | longer than unit length, P protein covalently bound at 5' end (primed by polymerase) |
| plus strand of hepadnavirus | smaller than unit length and variable, cap + rna oligonucleotide at 3' end |
| Organization of hepadnavirus genome | overlapping open reading frames |
| Proteins involved in hepadnavirus | surface proteins, core proteins, P protein, X protein |
| X Protein | involved in transcription activation |
| ___ and ___ are required for Reverse transcription to occur | core proteins and polymerase II |
| What makes the decoys noninfectious? | lack the nucleocapsid |
| how many overlapping reading frames? how many viral proteins? | 4 overlapping, 7 proteins (3 surface, 2 core, Polymerase, Protein X) |
| Is hepadnavirus dna integrated into the host genome? | no |
| What does reverse transcription need? | a place to bind to (pgRNA) and repeats (DR1 and DR2) |
| What are the activities of P protein? (4 domains) | Reversetranscription, RNAse H, Protein Priming, encapsidation |
| What does the RNAse H domain of the P protein degrade? | the pgRNA during genome replication |
| Where does hpadnavirus make glycoproteins | ER |
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