4 Written Questions

1. inhibits cell wall synthesis; inhibits peptidoglycan formation
2. B-lactam; Inhibits cell wall synthesis (preventing cross-linkage between peptidoglycan chains) e.g. cephalexin
3. inhibit nucleic acid synthesis; inhibits dihydrofolate reductase (inhibiting folate production, required for DNA replication)
4. B-lactam; Inhibits cell wall synthesis (preventing cross-linkage between peptidoglycan chains) e.g. amoxycillin

4 Multiple Choice Questions

1. inhibit protein synthesis; inhibits peptidyl transferase activity at 50S subunit e.g. erthromycin, roxithromycin
   1. macrolide
   2. tetracycline
   3. vancomycin
   4. Penicillin
2. inhibit nucleic acid synthesis; inhibit dihydrofolate synthestase (inhibiting folate production, required for DNA replication); bacteriostatic, most well absorbed from gut, cojugated by liver
   1. tetracycline
   2. Sulphonamide
   3. monobactam
   4. macrolide
3. B-lactam; Inhibits cell wall synthesis (preventing cross-linkage between peptidoglycan chains) e.g. imipenem
   1. monobactam
   2. vancomycin
   3. macrolide
   4. carbapenem
4. inhibits protein synthesis; binds to 30S subunit and inhibits binding of aminoacyl-tRNA
   1. monobactam
   2. aminoglycoside
   3. vancomycin
   4. macrolide

3 True/False Questions

1. Co-trimoxazole → mixture of trimethorprim and sulphamethoxazole (a sulphonamide); rapidly absorbed from GIT, excreted in urine, excreted by urine

   True        False

2. tetracycline → B-lactam; Inhibits cell wall synthesis (preventing cross-linkage between peptidoglycan chains) e.g. amoxycillin

   True        False

3. monobactam → B-lactam; Inhibits cell wall synthesis (preventing cross-linkage between peptidoglycan chains) e.g. aztreonam

   True        False