Pharm 4 Fedan alpha/beta agonists/antagonists

Created by MedSchoolAce 

Upgrade to
remove ads

Norepinepinephrine

direct acting agonist of a1,a2, b1; degraded by MAO and COMT

Epinephrine

direct acting agonist of a1,a2,b1,b2; degraded by MAO and COMT

Isoproteronol

Direct acting agonsit of B1 and B2

Dopamine

Direct acting agonist of B1 receptor; degraded by MAO and COMT

Phenylephrine

Direct acting agonist of a1; leads to nasal vein constriction to reduce nasal congestion; also used in hypotensive emergency

Methoxamine

direct acting agonist of a1; used in hypotensive emergency

Dobutamine

Direct acting agonist on a1 and b1 has selectivity towards B1; net effect is positive inotropy; Useful in treating CHF

Clonidine

direct acting agonist of a2, has CNS effects many side effects; used to treat HT

Oxymetazoline

direct agonist of a2, long acting and is used for nasal congestion (via nasal arterioles

Albuterol

B2 direct acting agonist, inhaled, used for broncospasm in asthma

Terbutamine

similar to albuterol in that it is a B2 direct acting agonist, it has a rapid onset of action

Ritodrine

B2 direct acting agonist administered IV, used for uterine relaxation in premature labor

Tyramine

Indirect acting agonist that increases the release of NE

Indirect acting agonists

class of alpha beta agonists that act by increasing release of NE resulting in increased BP adn HR, sever responses, tachyphylaxis is possible;

Indirect acting agonists indications

alerting/sleep deferring, narcolepsy, appetite suppression, adhd

Ephedrine

Indirect acting agonist of a,b; it is long acting; used to treat postural hypertension; has direct effects as well; severe toxicities including stroke, MI and death

Pseudoephedrine

Indirect acting agonists that has more effects on alpha rather than B than ephedrine; Tx: nasal congestion; it is a schedule II drug that can be used to make meth

Amphetamine

reverses NE and DA reuptake; blocks NE and DE reuptake and MAO, readily enters the CNS, has a high abuse potential and is used to treat ADHD

Phenylpropanolamine

Off market indirect acting agonist of alpha or B, it was taken off market because of hemorrhagic strokes

Phentolamine

alpha antagonist with a1=a2

Phentolamine or phenoxybenzamine

Tx pheochromocytoma and Raynauds

Phentolamine MOA

Equilibrium competitive antagonist of a1=a2, moderate duratio

Phentolamine adverse effects

orthostatic hypertension, tachycardia, miosis, nasal stuffiness, inhibited ejaculation, GI disturbances - resulting from histamine release

Phenoxybenzamine

a1>a2; nonequilibrium competitive antagonism; Inhibits ACH, 5HT, Histamine receptors, blocks NET and extraneuronal uptake; SE include Otrthostatic hypotension, tachycardia, Miosis, Nasal stuffiness. Inhibits ejaculation

Prazosin, terazosin, doxazosin, alfuzosin

a1 adrenoreceptor antagonists that are equilibrium competitive antagonists of moderate duration; Tx mild-moderate hypertension and BPH; **1st dose syncope, fewer reflex cardiac stimulation b/c it doesn't block presynaptic alpha receptors - at high doeses these are direct vasodilators; SE of residula orthostatic hypotension

Yohimbine

Drug used for erectile dysfunction; not very affective because it mainly acts on the CNS via a2 (essentially has the opposite effects as clonodine; will increase BP and heart rate

Ergotamine

alpha antagonist Interacts with 5HT and DA receptors; used to treat MIgraines

Ergonovine

alpha antagonist; Vascoconstriction adn oxytocic; used to treat post-partum hemmorrhage

Tamsulosin

Antagonist of a1a; Tissue specific and used to treat BPH; decrease contraction of urinary bladder, less contraction of prostate smooth muscle

Propanolol

B1, B2 receptor antagonist; acts by stabilizing the membrane (it is an anti-arrythmatic drug)

Nadalol

B1 B2 antagonist

Pindolol

B1 B2 antagonist with partial agonist activity and slight membrane stabilizaiton: less decrease in BP/HR than full antagonist

TImolol

nonselective b antagonist used in treatment of open angle glaucoma

Labelatol

nonselective antagonist of B receptors; it is a slight B2 agonist, has slight membrane stabilization; Tx: hypertension; decrease BP and inhibits the baroreceptor reflex

Carvedilol

Useful in early CHF, a very powerful antioxidant; eases the work that the heart must perform

Metoprolol

B1 inverse agonist, has slight membranes stabilization (antiarrythmatic) useful in HT and MI

Acetobutolol

B1 antagonist

Esmolol

B1 antagonist that has a fast acting, short duration; this is the "tunable" B antagonist

Butoxamine

B2 antagonist that is not really used since it leads to bronchoconstriction

Please allow access to your computer’s microphone to use Voice Recording.

Having trouble? Click here for help.

We can’t access your microphone!

Click the icon above to update your browser permissions above and try again

Example:

Reload the page to try again!

Reload

Press Cmd-0 to reset your zoom

Press Ctrl-0 to reset your zoom

It looks like your browser might be zoomed in or out. Your browser needs to be zoomed to a normal size to record audio.

Please upgrade Flash or install Chrome
to use Voice Recording.

For more help, see our troubleshooting page.

Your microphone is muted

For help fixing this issue, see this FAQ.

Star this term

You can study starred terms together

NEW! Voice Recording

Create Set