List the stpes in cholinergic transmission
Synthesis, storage, release, receptor activation, inactivation
What is the drug that inhibits Ach synthesis?
What drug inhibits storage of Ach?
How is Ach released?
Via exocytosis and leakage via carrier
What inhibits release of Ach?
Presynaptic toxins (eg, botulinum)
What are the key symptoms or botulism?
Nausea, vomiting, abdominal cramps, dry mouth, double vision
What are the therapeutic uses of botulinum toxin?
belopharospasm, hyperhidrosis, cerebral palsy
How are Ach receptors activated?
Released Ach diffuses across synaptic cleft to combine with receptors
How is the subtype of receptor activated determined?
By the location of the receptor
What inhibits the inactivation of Ach?
What are the therapeutic uses of anticholinesterases?
Myasthenia gravis, Alzheimer's disease
What are the side effects of anticholinesterase use?
Increased salvation, nausea, vomiting, diarrhoea, abdominal cramps
What is the key symptom of anticholinesterase poisoning?
Enhancement of Ach activity
How is anticholinesterase poisoning treated?
Artificial ventilation, block muscarinic actions of Ach (atropine)
What are muscarinic agonists called?
What are muscarinic antangonists called?
What are the therapeutic uses of muscarinic agonists?
Constriction of pupil, decrease intraocular pressure, reversal of mydriasis, treatment of glaucoma, stimulation of GIT motility, stimulation of bladder, treatment of cognitive impairment.
What are two examples of parasympatholytics?
What are the periphral effects of anticholinergic syndrome?
Flushed, dry mouth, blurred vision, tachycardia, constipation, hyperthermia
What are the central effects of anticholinergic syndrome?
confusion, coma, convulsions
What are the CNS effects of muscarinic antagonists?
WHat are the therapeutic uses of antimuscarinics?
Dilation of pupil, asthma, anaesthetic premedication, prevent motion sickness, counteract movement disorders