1.
2 Catecholamines: Racemic epinephrine, Isoetharine
2.
3 Chemical classes of B2 agonist: 1 Catecholamines 2 Resorcinols 3 Saligenins
3.
adrenergic: sympathomimetic (Beta Agonist), most commonly prescribed
4.
Albuterol: Probentil, Ventolin..Onset 15min, Peak 30-60 minutes Duration 5-8 hrs MDI SVN TABLET(extended release), Syrup(children) DPI
5.
Alpha receptor stimulation: Vasoconstriction, decrease blood flow, decrease in swelling
6.
Arformoterol: Brovana Long Lasting Saligenen..SVN ONLY
7.
B1 receptor stimulation: INCREASE in heart rate INCREASE in force of contration
8.
B2 stimulation: Bronchodialation
9.
Bronchoconstriction: 1 Bronchospasm, 2 Secretions 3 Edema(fluid in tissues)
10.
cAMP: cyclic adenosine 3-5 mono phosphate
11.
Chemical structure includes...: Benzene Ring and Side Chains
12.
Classifications by duration: Ultra short acting, Short acting, Long Acting
13.
Continous Nebs: used for severe asthma (ER), Dosage from 2.5 - 15 mg/hr...uses a large volume reservoir...Close, continous monitoring necessary...Used with a MASK (don't want to tire pt with mouthpiece)
14.
Finding when changing Benzene Ring..: Longer acting drugs
15.
Finding when changing Side chain..: Less side effects..more specific to B2 Receptors
16.
Formoteral: Foradil...Long Lasting Saligenen..DPI SVN
17.
Isoetharine: Turns pts sputum PINK
18.
Isoetharine: Bronkosol
19.
Levalbuterol: Xopenex FEWER SIDE EFFECTS THAN ALBUTEROL Onset 15 minutes, Peak 30-60 minutes Duration 5-8 hrs SVN and MDI
20.
Mechansim of Action: B2 Agonist<B2 Receptor<Activates G Proteins<Enyme(Adenylcylase)<INCREASE cAMPStops smooth muscle from contraction
21.
Metaproterenol: Alupent
22.
Metaproterenol Information:: Tablet, syrup(children), inhaled MDI or SVN..works in 1-5 minutes Peak 30minutes Lasts 2-6 hrs
23.
Oldest Group of bronchodilator: Catecholamines
24.
Pirbuterol: Maxair BREATH actueated MDI and syrup.
25.
Racemic epinephrine: Vaponefrin
26.
Resorcinols: 2nd Class Longer lasting bronchodilators, worked for 4-6 hrs.
27.
Saligenins: 3rd Class, Longer than Resorcinols, More Beta 2 specific, less side effects
28.
Salmeterol: Serevent..Long Lasting Saligenen...Available MDI DPI(green Diskus)
29.
Side effects of B2 agonist: Tremors, tachycardia, arrhythmias, CNS(dizziness, anxiety, nervousness, headache, insomnia), Metabolic disturbances..hyper or hypo glycemia
30.
Terbutaline: Brethine
31.
Terbutaline Information:: MDI only
32.
Three Saligenins: Albuterol, Pirbuterol, Levalbuterol
33.
Two Resorcinols: Metaproterenol, Terbutaline
34.
Tx for bronchospasm: bronchodilator
35.
Tx for edema: steroids
36.
Tx for secretions: mucolytic
37.
Uses for racemic Epinephrine: WEEK BRONCHODILATOR Good for use as a Cardiac stimulant, anaphylactic reactions, TOPICAL..tx of upper airway edema Ex. Croup, epiglotitis, Stridor