| Term | Definition |
|---|
| hemostasis | arresting of bleeding |
| thrombosis | excessive platelet-fibrin plug formation at the site of origin which may block circulation |
| embolism | blocking of blood vessel downstream due to breakoff of the platelet-fibrin plug |
| dilation | NO causes ____ of blood vessels |
| dilation | prostacyclin causes _____ of blood vessels |
| constriction | 5-HT causes _____ of blood vessels |
| constriction | TXA2 causes ______ of blood vessels |
| vWF | platelets bind to collagen via _____ |
| platelets to bind to collagen | von Willenbrand factor causes |
| vitamin K, vitamin C, vWF | deficiencies in what three molecules can cause bleeding disorders |
| deficiency in collagen synthesis | What causes Ehlers-Danlos syndrome? |
| GPIb-IX | vWF binds to collagen and platelets via what receptor? |
| vit C deficiency, excessive exogenous and endogenous corticosteroids | Three examples of acquired vascular bleeding disorders |
| Ehlers-Danlos syndrome | An example of a congenital vascular bleeding disorder |
| adhesion of platelets to vessel wall | What forms the initial (primary) hemostatic plug after injury? |
| formation of fibrin | What forms the secondary hemostatic plug after an injury? |
| platelet activation | What happens when blood is exposed to collagen? |
| ADP, epinephrine, collagen, thrombin, PAF, immune complexes, high physical shear stress, high blood pressure | Name 8 platelet activating factors |
| GP3b-3a | fibrinogen aggregates via the ______ receptor |
| desmopressin | used to treat von Willebrand disease |
| VIII | What coagulation factor does vWF carry? |
| ADP, 5-HT, TXA2, vWF | Which compounds are released when platelets are activated? |
| aspirin, dipyridamole, clopidogrel, ticlodipine, TXI, TXRI | examples of antiplatelet drugs (6) |
| inhibit ADP | how does dipyridamole prevent platelet activation? |
| block ADP receptor | how does clopidogrel prevent platelet activation? |
| block ADP receptor | how does ticlodipine prevent platelet activation? |
| thromboxane synthetase | what enzyme does TXI inhibit? |
| block TXA2 receptors | how does TXRI prevent platelet activation? |
| 12 | What is the only coagulation factor whose deficiency does not cause excessive bleeding |
| 9 (from 11 and 7), 5, 8, 13, stabilized fibrin | What coagulation factors does Ca play a role in activating? |
| hemophilia | What can be caused by a deficiency in coagulation factor 8? |
| 11, 9 | coagulation factor 8 is a cofactor for coagulation factor _____ |
| 10 | coagulation factor 5 is a cofactor for coagulation factor ___ |
| 30 - 50 seconds | normal APTT is |
| thrombin or tissue factor | tests of the intrinsic pathway do not involve addition of ____ or ____ to the blood |
| intrinsic pathway | what pathway test can be conducted to rule out common congenital hemophilia? |
| prothrombin time (PT) | clinical test involving the extrinsic pathway measures ____ |
| 10 - 15 seconds | normal PT is |
| heparin | What activates antithrombin? |
| 9, 10, thrombin | antithrombin inactivates |
| 3 | TPFI inhibts what coagulation factor? |
| 5, 8 | the protein c - protein S complex directly inhibits what coagulation factors? |
| thrombin | the protein C-protein S complex is activated by _____ |
| liver and endothelium | where is TPFI synthesized? |
| degrades fibrin to FDP | what does plasmin do? |
| tPA, streptokinase, uPA | how can plasmin be activated? |
| lysine | what amino acid is involved in the binding of plasmin to fibrin |
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