Furosemide (Lasix)

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Class

Loop diuretic

Action

Decreases preload by vasodilation effect in less than 5 minutes
Inhibits electrolyte reabsorption in the distal loop of henle, and promotes the excretion of sodium, potassium, hydrogen, magnesium, and chloride to decrease circulating blood volume by it's diuretic effect within 5-30 minutes

Indications/uses

Cardiogenic pulmonary edema
CHF

Contraindications

Anuria, Hypersensitivity, hypovolemia/dehydration, states of severe electrolyte depletions, known hypersensitivity to sulfonamides

Side effects

CNS: Dizziness, Headache, Tinnitus, Vertigo
Cardio: Arrhythmias, Hypotension
GI: Diarrhea, nausea, vomiting
Other: Hypovolemia, hypokalemia, hyponatremia, metabolic acidosis

Drug interactions

Digitalis toxicity may be potentiated due to potassium depletion, which can result from furosemide administration
Lithium toxicity may be potentiated due to sodium depletion

Preparations

20 mg/2 ml ampule/preload
40 mg/4 ml ampule/preload
100 mg/10 ml vial/preload

Adult dose

Not taking lasix: 40-80 mg
Taking lasix: 20-40 mg
May repeat p.r.n. to a maximum of 2 mg/kg. Do not exceed 20 mg/min

Pediatric dose

1 mg/kg slowly. May repeat p.r.n. to a maximum of 2 mg/kg
Note: Usually not given to pediatrics in prehospital setting

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