One of the longitudinal parallel, thread-like structure in striated muscle cells. It is made up of actin and myosin.Contractile elements surrounded by sarcoplasm.
A globular protein with myosin binding sites; Tropomysin & Troponin are 2 proteins associated with the surface of this filament.
Consists of 2 twisted strands with globular cross-bridges projected outward along the strands.
Most abundant protein in muscle tissue and the main constituent of the thick filaments of muscle fibers
globular heads that attach to myosin binding sites on the thin filaments during muscle activation; ATP binds here
globular head of myosin molecule that projects from a myocin filament in muscle & in the sliding filament hypothesis of muscle contraction is held to attach temporarily to an adjunct actin filament & draw it into the A band of sarcomere between the myosin filaments
myosin cross-bridges now bind & pull on the actin filaments, causing these to shorten.
basic unit of contraction within a muscle fiber;small, repeating segments of myofibril between two adjacent z-lines
"anchoring protein" that functions as a molecular ruler that specifoes the length of the thick (myosin) filament. It connects m line to z line, maintains the position of the myosin in the center of the sarcomere and prevents the sarcomere from being pulled apart (resting tension).
titin filamentous molecules keep myocin & actin filaments inplace. Titin is made of large number filamentous molecules of proteins.
Membrane structure surrounding myofibrils;
contains calcium, which stimulates sarcomere contraction upon release
Larger of the two proteins that are part of actin filament.
protein in actin that blockades the myosin binding sites; in a relaxed muscle, it blocks it from being contracted all the time
smaller of two proteins that are part of actin filament. Attached intermittently along side of tropomysin molecules are still other protein molecules called troponin.
believed to attach the tropmyosin to the actin. The strong affinity of troponin for calcium ions is believed to intiate the contraction process.
motor unit/motor end plate
A single motor neuron and the group of muscle fibers which it innervates. The size of these is an indication of how fine the precision of movement can be (the greater the number of fibers controlled by one neuron the less precision).
A summary: The steps involved in contraction are as follows: Ach release from synaptic vesicles>binding of Ach to the motor end plate>generation of an electrical impulse in the sarcolemma>conduction of the impulse along T tubules>release of calcium ions by the SR>exposure of active sites on the thin filaments>cross-bridge information and contraction.
Anchoring protein" functions as a molecular ruler that specifies the lenght of the thin (actin) filament.
The step in the sliding filament theory during which myosin undergoes a conformational change to its low energy state, in the process dragging the thin filaments (and the attached Z lines) toward the center fo the sarcomere.
Three sources of energy by which ATP is restored....
first source of energy used to reconstitute ATP;carries a high-energy phosphate bond similar to the bonds of ATP
second source of energy used to reconstitiute both ATP & phosphocreatine. Glycolosis of glycogen previously stored in muscle cells.
third source of energy, it combines oxygen with the end products of glycolysis and with other cellular foodstuffs to liberate ATP.
More than 95% of all energy used by muscles for sustained, long-term contraction is derived from this source.
muscle length shortens and moves the load, the tension remains constant througout the contraction (concentric)
fast twitch muscles
white muscle/glycolytic; extensive SR for rapid release of calcium ions to intiate contraction; fewer mitochondria, fewer blood vessels, no myoglobin, fatique quickly, can't replenish ATP for prolonged contraction