Endocrine System

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Hyposecretion of the pancreas

Diabetes Mellitus

Hyposecretion of growth hormone

Pituitary Dwarfism

Hyposecretion of the adrenal cortex

Addison's Disease

Hypersecretion of growth hormone

Acromegaly

Hyposecretion of the thyroid in infants

Cretinism

Hypersecretion of the adrenal cortex

Cushing's Disease

The gland that controls the fight-or-flight reaction

Adrenal Medulla

Produces hormones that regulate glucose levels in the body

Pancreas

Produces the body's major metabolic hormones

Thyroid

Produces a hormone that controls blood levels of calcium and potassium by their removal from bone tissue

Parathyroid

The size and shape of a pea; produces hormones that stimulate other endocrine glands

Hypophysis

In humans, melatonin may inhibit sexual maturation

True

Follicle cells of the thyroid gland produce thyroglobulin, while follicle cells of the parathyroid produce calcitonin

False

The thyroid gland is embedded in the parathyroid tissue

False

The prime metabolic effect of cortisol is gluconeogenesis

True

The beta cells are the pancreatic islet cells that produce insulin

True

Peptide hormones enter the target cells and elicit a response by mediating neurotransmitter effects

False

Calcitonin is a peptide hormone that has destructive effects on the skeletal system

False

Aldosterone is the most potent mineralocorticoid produced in the adrenals but the least abundant

False

Atrial natriuretic peptide is a hormone that controls blood pressure in part by increasing the urinary excretion of sodium

True

While glucagon is a small polypeptide, it is nevertheless very potent in its regulatory effects

True

The thyroid gland is a large gland that controls metabolic functions throughout the life of an individual

True

The antagonistic hormones that regulate the blood calcium level are calcitonin-parathormone

True

Many hormones synthesized in the gastrointestinal tract are chemically identical to brain neurotransmitters

True

All of the following hormones are secreted by the adenohypophysis: ACTH, FSH, and LH

True

Iodine is an essential element required for the synthesis of thyroxine

True

The endocrine gland that is probably malfunctioning if a person has a high metabolic rate is the parathyroid

False

Growth hormone always exerts its influence by targeting other endocrine glands to produce hormones

False

Diabetes insipidus and diabetes mellitus are both caused by a genetic mutation involving the synthesis of insulin

False

The stimulus for calcitonin release is usually excessive amounts of growth hormone synthesis

False

Glucocorticoids are steroid hormones that usually enhance the immune responses when an individual is suffering from severe stress

False

Direct gene activation involves a second-messenger system

False

All peptide hormone synthesis requires gene activation that produces mRNA

True

The hormone that raises blood sugar levels is insulin

False

All adenohypophyseal hormones except GH affect their target cells via a cyclic AMP second-messenger

True

The endocrine structure that develops from the nervous system is the anterior pituitary

False

Both "turn on" factors (hormonal, humoral, and neural stimuli) and "turn off" factors (feedback inhibition and others) may be modulated by the activity of the nervous system

True

ACTH stimulates the adrenal cortex to release corticosteroid hormones

True

LH is also referred to as a gonadotropin

True

The only known effect of prolactin in humans is to produce impotence in males

False

Oxytocin is a strong stimulant of uterine contractions

True

Gluconeogenesis occurs in the liver due to the action of ________.

Cortisol

ADH ________.

is inhibited by alcohol

Thyroid hormone exerts its influence by ________.

entering some cells and binding to intracellular receptors within the nuclei.

Gonadocorticoid(s) ________.

production by the adrenal gland is insignificant compared with sex hormone release from the gonads during late puberty

Sometimes prolonged excessive exposure to high hormone concentrations causes a phenomenon known as ________.

down-regulation

Which of the following is not a change that may be caused by hormonal stimulus?

direct control of the nervous system

The ability of a specific tissue or organ to respond to the presence of a hormone is dependent on ___

the presence of the appropriate receptors on the cells of the target tissue or organ

Several hormones are synthesized in the hypothalamus and transported to the anterior pituitary gland. The mechanism of transportation from hypothalamus to anterior pituitary gland is through the ________.

hypophyseal portal system

The neurohypophysis or posterior lobe of the pituitary gland is not a true endocrine gland because ________.

it is only a hormone storage area that receives hormones from the hypothalamus for release

Insulin, a small (51-amino-acid) protein, is synthesized by the beta cells of the pancreas. This hormone is released ________.

when the body's glucose level rises

Steroid hormones exert their action by ________.

entering the nucleus of a cell and initiating or altering the expression of a gene

Normal development of the immune response is due in part to hormones produced by the ________.

Thymus gland

The second-messenger mechanism of hormone action operates by ________.

binding to specific receptors and employing the services of G proteins and cAMP

Hormones often cause a cell to elicit multiple responses; this is because ________.

during protein kinase activation, enzymes phosphorylate many other enzymes

Cells that respond to peptide hormones usually do so through a sequence of biochemical reactions involving receptor and kinase activation. In order for cells to respond, it is necessary for first and second messengers to communicate. This is possible because ________.

G protein acts as the link between first and second messengers

Thyroid hormone (a small iodinated amine) enters target cells in a manner similar to ________.

steroid hormones, because both diffuse easily into target cells

When it becomes necessary to enlist the fight-or-flight response, a hormone that is released during the alarm phase of the general adaptation syndrome is ________.

Epinephrine

One of the least complicated of the endocrine control systems directly responds to changing blood levels of ions and nutrients. Which of the following describes this mechanism?

humoral stimulation

The major targets of growth hormone are ________.

bones and skeletal muscles

The parathyroid glands maintain adequate levels of blood calcium. This is accomplished through ________.

targeting the bone and activating osteoclasts so that calcium will be released

Which organ is responsible for synthesizing ANP?

Heart

Mineralocorticoid is to aldosterone as glucocorticoid is to ________.

Cortisol

Virtually all of the protein or amino acid-based hormones exert their effects through intracellular ________.

Second messengers

Leptin is secreted by ________.

Adipocytes

The most important regulator of electrolyte concentrations in extracellular fluids is ________.

Aldosterone

Which of the following is not a steroid-based hormone?

Epinephrine

Which of the following does not act as a second messenger in second-messenger systems of hormone action?

Calmodulin

Select the correct statement about the structure or function of chemical messengers.

An amino acid derivative can be a hormone

Which of the following would be associated with the action of steroids on cells?

a hormone-receptor complex that interacts directly with the cell's DNA

Cellular responses to hormones that initiate second-messenger systems include ________.

possible activation of several different second-messenger systems

Regulating hormones from the hypothalamus ________.

first enter into the hypophyseal portal system

ACTH ________.

secretion is regulated by a hypothalamic secretion

Which of the following is true about calcium homeostasis?

Parathyroid hormone is the single most important regulator of calcium levels in the blood

Which of the following is not a category of endocrine gland stimulus?

Enzyme

Aldosterone ________.

functions to increase sodium reabsorption

The only amine hormone to act like a steroid is ________.

Thyroid Hormone

Which organ does not have hormone production?

Liver

In circumstances where the body requires prolonged or increased levels of a hormone, the DNA of target cells will specify the synthesis of more receptors on the surface of the cells of the target organ. This is known as ________.

Up-regulation

Eicosanoids do not include ________.

Hydrocortisones

A man has been told that he is not synthesizing enough follicle-stimulating hormone (FSH), and for this reason he may be unable to father a child. Choose the correct statement to explain this problem.

FSH stimulates sperm production in the testes

Which of the following organs is affected by thyroid hormone in adults?

Liver

Thyroxine is a peptide hormone, but its mechanism is different from other peptide hormones. Which of the following statements is true concerning this difference?

It does not require a second messenger to effect a response

Factors that inhibit TSH release do not include ________.

excessively high blood iodine concentrations

Glucocorticoids enable the body to deal appropriately with stress. They accomplish this by ________.

increasing blood glucose, fatty acid, and amino acid levels and enhancing blood pressure

Chemical substances secreted by cells into the extracellular fluids that regulate the metabolic function of other cells in the body are called ________.

Hormones

What ion is sometimes used as a second messenger of amino acid-base hormones?

Calcium

The hypothalamic-hypophyseal tract ________.

is partly contained within the infundibulum

Tropic hormones ________.

include ACTH and TSH

Growth hormone ________.

promotes long bone growth during the formative years

Oxytocin ________.

release is an example of a positive feedback control mechanism

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