a very tight binding inhibitor of the aspartate transcarbamoylase active site.
Familial infantile autism
caused by a deficiency of adenylosuccinate lyase. Cant make AMP from IMP.
transplant anti rejection drug that inhibits IMP dehydrogenase. Cant make GMP from IMP.
Lesch Nyhan Syndrome
complete absence of HGPRTase enzyme. Cant take free base and stick on sugar for guanine.
a free radical scavenger used as anticancer drug and for sickle cell disease. Inhibits ribonucleotide reductase so can't make deoxyribonucleotides.
master off switch for synthesis of all dXDPs.
an analogue of DHF that inhibits dihydrofolate reductase. Inhibits synthesis of A, G and T. Used for cancer, rheumatoid arthritis. Often given in large doses and rescued by leucovorin.
rescue drug for methotrexate. Competes with methotrexate in normal cells allowing them to live.
analogue of methotrexate used to treat bacterial infection. Given with sulfamethoxazole, together called bactrim. Overall, previous prevents recycling of THF and latter prevents Folate synthesis.
specifically inhibits thymidylate synthase so can't make TMP. First converted to active form by salvage enzymes. Then binds covalently to enzyme and makes it dead.
Adenosine deaminase deficiency
causes SCID from build up of adenosine and deoxyadenosine.
PEG ADA therapy
attaché PEG to lysine group of bovine ADA and give to patient in blood.
used to treat CLL. Creates an artificial ADA deficiency with a deoxyadenosine analogue resistant to degradation.
an inhibitor of xanthine dehydrogenase (oxidase). Oxidized by enzyme but binding of product oxypurinol inactivates enzyme by locking it in MO +4 state. Uric acid synthesis inhibited. Further added to PRPP by HGPRTase and feedback inhibits PPN for reduction of purine synthesis. Two punch combo.