abnormalities of reproductive development
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Created by:
katieyoung42 on January 30, 2010
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27 terms
Terms | Definitions |
|---|---|
 double uterus and double vagina | characterized by two uteri/vaginas side by side |
| double uterus and double vagina | caused by incomplete fusion of mullerian ducts, incomplete recanalization of sinovaginal plate |
| double uterus | caused by incomplete fusion of mullerian ducts into uterovaginal primodium |
| bicornuate uterus | two uteri, single vagina, caused by partial fusion of the mullerian ducts |
| bicornuate uterus | two uteri, single vagina, and small oviduct, caused by retarded growth of one mullerian duct so does not fuse with other in midline |
| septate uterus | septum dividing lumen of uterus in two, caused by wall between fused mullerian ducts in uterovaginal primordium fails to degenerate |
| unicornuate uterus | partial uterus, single oviduct and vagina, caused by development of single mullerian duct |
| Hypospadias | most common anomaly of penis, opening of ext urethral orifice on ventral surface of penis, from failure of UG fols to fuse in midline, from inadequate production of androgens or receptor sites |
| glans or penile hypospadias | 80% of hypospadias |
| glands hypospadias | ext urethral opening at base of glands |
| penile hypospadias | ext urethral opening anywhere along shaft of penis |
| penoscrotal hypospadias | ext urethral opening at junct between penis and scrotum |
| perineal hypospadias | ext urethral opening includes scrotum and length of penile shaft, severe= pseudohermaprodites |
| persistent processus vaginalis | PV fails to close, prediposes congenital inguinal hermia |
| hydrocele of spermatic cord | middle portion of processus in scrotum remains open |
| hydrocele of testis | lower end of processus remains open and dilates around testis, fluid fills from peritoneum |
| cryptorchidism | failure of testes to descend into scrotum, unilat/bilat, 30% of all premature males, sterility results if undescended due to heat sensitivity |
| inersexuality or hermaphroditism | discrepancy between the morphology of the gonads and appearance of ext genitalia |
| ambiguous genitalia | when the appearance of genitalia can't be used to determine sex |
| ambiguous genitalia, intersexuality | due to erros in sex derm. or differentiation during development |
| true hermaphrodites | have both ovarian and testicular tissue in same or opposite gonads |
| femal pseudoermaphrodites | have ovaries |
| male psudohermaphrodites | have tests |
| true hermaphrodites | have barr bodies, 70% genetic females, 20% genetic mosaics, 10% genetic males, extremely rare |
| female psuedohermaphrodites | have barr bodies, have ovaries with ambiguous genitalia, enlarge clit, fused labia, persistent UG sinus, caused by excessive androgens, most have CAH |
| male pseudohermaphrodites | lack of barr bodies, genetically male, have testes with varying external genitalia, paramesonephric ducts, low levels of testosterone and MIS |
| androgen insensitivity syndrome | chromatin negative, genetically male, female ext genitalia, vagina ends in blind pouch, uterus, and uterine tubes absent or rudimentary, estrogen comes from conversion of androgens produced by adrenal cortex, no menstruction, testis in abdomen or inguinal canal, cause is from defect in androgen receptors in genital tubercle |
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