male reproductive endocrinology

12 terms by tmclaughlin

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Leydig cells

These cells contain the LH-R, lie outside the seminiferous tubule, and produce testosterone

Sertoli cells

These cells contain the FSH-R, lie within the seminiferous tubule, and produce a number of products (ex. MIF, ABP, inhibin)

Androgen binding protein

This product of the sertoli cells sequesters large concentrations of testosterone within the seminiferous tubule

inhibin

This product of the Sertoli cells inhibits production of FSH in the pituitary

GnRH

This hypothalamic hormone stimulates the production of FSH and LH

testosterone

This testicular product negatively feeds back to inhibit LH and GnRH production

17-beta-HSD

This enzyme converts both DHEA and androstenedione into testosterone

5-alpha reductase

This enzyme peripherally converts testosterone to dihydrotestosterone

estradiol

The action of aromatases converts testosterone to this

Sex Hormone Binding Globulin

Most serum testosterone is bound to this protein

albumin

Most serum estradiol is bound to this protein

finasteride

This 5-alpha reductase antagonist is used in the medical treatment of prostate cancer

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