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neutrophils

most abundant circulating wbc. 4k per microliter. usually first to arrive at infection, emigration, (+) chemotaxis, limited phagocytic, fill up with pathogen.

neutrophils secrete

defensive compounds. defensis and oxidant toxins

defensins

poke holes in membrane of pathogen, ruptures

oxidant toxins

damage and kill pathogen

eosinophils

emmigration, (+) chemotaxis, small amount phagocytic. 165 per microliter

eosinophils secrete

histamines and digestive enzymes

histamines

inflammation

digestive enzymes

release these enzymes on parasite, digest it

basophils

44 per microliter. emmigration, most basophils are in tissue, (+) chemotaxis, almost no phagocytosis.

basophils secrete

heparin and histamines

heparin

anticoagulant

lymphocytes

2k per microliter. emmigration, can move back and forth between blood and tissues. (=) chemotaxis, no phagocytosis. specific immunity. provides memory or immunity to pathogen after initial exposure.

lymphocytes types

t cells and b cells

monocytes

450 per microliter. emigration, move into tissue and converts in macrophages, (=) chemotaxis, phagocytic (agressive and unlimited). some of these in specific tissues such as lung, skin, gi tract, bone marrow, spleen, lymph nodes and liver

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