Autoimmune I
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27 terms
Terms | Definitions |
|---|---|
 HLA-B27 | ankylosing spondylitis, acute anterior uveitis |
| HLA-DR2 | goodpasture's syndrome, MS |
| HLA-DR3 | graves disease, myasthenia gravis, SLE |
| HLA-DR3/4 heterozygote | DM type 1 |
| HLA-DR4 | RA, pemphigus vulgaris |
| HLA-DR5 | hashimoto's thyroiditis |
| disease: APD or APECED | defective AIRE gene |
| disease: APD or APECED | Finns, sardinians, iranian jews |
| disease: goodpasture's syndrome | autoantigen: non-collagenous domain of basement membrane collagen type IV |
| disease: pemphigus vulgaris | autoantigen: epidermal cadherin |
| disease: myasthenia gravis | autoantigen: acetylcholine receptor |
| disease: autoimmune hemolytic anemia | autoantigen: Rh blood group antigens, I antigen |
| disease: autoimmune hemolytic anemia | IgG & IgM antibodies bind to components of erythrocyte surfaces leading to complement activation (classical) |
| disease: goodpasture's syndrome | inflammatory destruction involving basement membrane of renal glomeruli (rapidly progressive GN) and basement membrane of lung alveoli (necrotizing hemorrhagic interstitial pneumonitis) |
| disease: goodpasture's syndrome | linear IgG on GBM and alveolar membrane |
| disease: pemphigus vulgaris | involves mucosa and skin; may first appear as an oral ucler; primary lesions are superficial vesicles and bullae that rupture easily |
| disease: pemphigus vegetans | usually presents with large, moist, verrucous (wartlike), vegetating plaques studded with pustules; present on axilla, groin, and flexural surfaces |
| disease: pemphigus foliaceus | occurs in S. America; sites of prediliction are scalp, face, chest, back; mucous membrane rarely affected |
| disease: pemphigus erythematous | may selectively involve malar area of the face in a lupus erythematosus-like fashion |
| disease: pemphigus foliaceus | autoantibodies react with desmoglein1 (superficial layers of epidermis) |
| disease: pemphigus vulgaris | autoantibodies react with desmoglein 3 (deeper layer of epidermis) |
| disease: rheumatic fever | the basis for its pathogenesis is molecular mimicry |
| disease: graves disease | patients with this disease have a higher risk of developing pernicious anemia, myasthenia gravis, DM type I, addison's disease, celiac disease |
| disease: hashimoto's thyroiditis | may be drug-induced (amiodarone, IFN-a, IFN-b, IL-2, G-CSF) |
| disease: hashimoto's thyroiditis | may be associated with IBD, celiac disease, turner's syndrome |
| disease: myasthenia gravis | early Sx: droopy eyelids, double vision; subsequently: weakness of other facial muscles |
| disease: myasthenia gravis | Dx with edrophonium, confirm with detection of antibody to Ach receptor, treat with pyridostigmine and azathioprine |
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