| Term | Definition |
|---|
| Vincristine Vinblastine | Chemotherapy; Natural Products; Vinca Alkaloids Two of the most potent plant-derived antitumor agents Binds tubulin, favoring depolymerization Resistance due to MDR |
| Vinorelbine | Chemotherapy; Natural Products; Vinca Alkaloids • Semisynthetic derivative of vinblastine with increased specificity for microtubules |
| Paclitaxel (Taxol) | Chemotherapy; Natural Products; Taxanes Treatment of breast and ovarian cancer when chemotherapy has failed Inhibits disassembly of microtubules, blocking reorganization Resistance due to MDR |
| Docetaxel | Chemotherapy; Natural Products; Taxanes • Semisynthetic analogue of paclitaxel |
| Etoposide Teniposide | Chemotherapy; Natural Products; Epipodophyllotoxins Semisynthetic glycosidic derivatives from a mandrake plant Inhibit topoisomerase II For Hodgkin's disease, diffuse histiocytic lymphoma, and small cell carcinoma of the lung (2) |
| Irinotecan | Chemotherapy; Natural Products; Camptothecin derivatives Inhibit topoisomerase I • Prodrug effective in the treatment of metastatic colorectal cancer |
| Topotecan | Chemotherapy; Natural Products; Camptothecin derivatives Inhibit topoisomerase I • For treatment of ovarian and small cell lung carcinoma |
| Irinotecan | Chemotherapy; Natural Products; Camptothecin derivatives Inhibit topoisomerase I • Prodrug effective in the treatment of metastatic colorectal cancer |
| Topotecan | Chemotherapy; Natural Products; Camptothecin derivatives Inhibit topoisomerase I • For treatment of ovarian and small cell lung carcinoma |
| Dactinomycin (actinomycin D) | Chemotherapy; Natural Products; Antibiotics Composed of a planar phenoxazone to which identical polypeptides are attached Intercalates between adjacent G:C base pairs Inhibits RNA at low, RNA and DNA at high concentrations Causes radiation sensitization |
| Bleomycin | Chemotherapy; Natural Products; Antibiotics DNA and iron binding region S peptide binds to DNA, leading to depurination and depyrimidation Resistance due to bleomycin hydrolase |
| Daunorubicin Doxorubicin Mitoxantrone | Chemotherapy; Natural Products; Antibiotics • Cause DNA intercalation and introduce single strand breaks (3) |
| Dexrazoxane | Chemotherapy; Natural Products; Antibiotics Anthracyclines • Iron chelator that inhibits free radical formation and can be used to reduce cardiac damage |
Combine with other sets
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