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Inflammation, Organization, Regeneration

What are the three steps of tissue repair?

Inflammation

Macrophages, mast cells, and injured tissue cells release inflammatory chemicals

Inflammation

White blood cells, plasma fluid, and antibodies flow to the area

Inflammation

Clotting factors from plasma fluid form a clot and close and seal the wound (scab)

Organization

Blood clot is replaced by granulation tissue

Organization

Fibroblasts fill the would and secrete collagen

Organization

Macrophages digest original blood clot

Regeneration

Surface epithelium begins to regenerate and grows under the scab, eventually replacing it

Regeneration

Scar tissue from fibroblasts remain

Regeneration

Replacement of old tissue with the same kind of tissue

Fibrosis

Replacement of old tissue with scar tissue (fibrous connective tissue)

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