PBM Module 2: Renal--The Body Fluid Compartments

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What is the daily intake of water? What two sources make it up?

Water is added to the body by two major sources:
(1) It is ingested in the form of liquids or water in the food, which together normally add about 2100 ml/day to the body fluids, and
(2) it is synthesized in the body as a result of oxidation of carbohydrates, adding about 200 ml/day. This provides a total water intake of about 2300 ml/day (Table 25-1). Intake of water, however, is highly variable among different people and even within the same person on different days, depending on climate, habits, and level of physical activity.

What is insensible water loss?

Some of the water losses cannot be precisely regulated. For example, there is a continuous loss of water by evaporation from the respiratory tract and diffusion through the skin, which together account for about 700 ml/day of water loss under normal conditions. This is termed insensible water loss because we are not consciously aware of it, even though it occurs continually in all living humans.

Describe insensible water loss through the skin

The insensible water loss through the skin occurs independently of sweating and is present even in people who are born without sweat glands; the average water loss by diffusion through the skin is about 300 to 400 ml/day

What minimizes insensible water loss through the skin?

This loss is minimized by the cholesterol-filled cornified layer of the skin, which provides a barrier against excessive loss by diffusion. When the cornified layer becomes denuded, as occurs with extensive burns, the rate of evaporation can increase as much as 10-fold, to 3 to 5 L/day. For this reason, burn victims must be given large amounts of fluid, usually intravenously, to balance fluid loss.

Describe insensible water loss through the reparatory tract. What exacerbates it?

Insensible water loss through the respiratory tract averages about 300 to 400 ml/day. As air enters the respiratory tract, it becomes saturated with moisture, to a vapor pressure of about 47 mm Hg, before it is expelled. Because the vapor pressure of the inspired air is usually less than 47 mm Hg, water is continuously lost through the lungs with respiration. In cold weather, the atmospheric vapor pressure decreases to nearly 0, causing an even greater loss of water from the lungs as the temperature decreases. This explains the dry feeling in the respiratory passages in cold weather.

Describe fluid loss by sweat.

The amount of water lost by sweating is highly variable, depending on physical activity and environmental temperature. The volume of sweat normally is about 100 ml/day, but in very hot weather or during heavy exercise water loss in sweat occasionally increases to 1 to 2 L/hour. This would rapidly deplete the body fluids if intake were not also increased by activating the thirst mechanism discussed in Chapter 29.

Describe fluid loss by feces.

Only a small amount of water (100 ml/day) normally is lost in the feces. This can increase to several liters a day in people with severe diarrhea. For this reason, severe diarrhea can be life threatening if not corrected within a few days.

Describe water loss by the kidneys

-The remaining water loss from the body occurs in the urine excreted by the kidneys. There are multiple mechanisms that control the rate of urine excretion. In fact, the most important means by which the body maintains a balance between water intake and output, as well as a balance between intake and output of most electrolytes in the body, is by controlling the rates at which the kidneys excrete these substances. For example, urine volume can be as low as 0.5 L/day in a dehydrated person or as high as 20 L/day in a person who has been drinking tremendous amounts of water.
-This variability of intake is also true for most of the electrolytes of the body, such as sodium, chloride, and potassium. In some people, sodium intake may be as low as 20 mEq/day, whereas in others, sodium intake may be as high as 300 to 500 mEq/day. The kidneys are faced with the task of adjusting the excretion rate of water and electrolytes to match precisely the intake of these substances, as well as compensating for excessive losses of fluids and electrolytes that occur in certain disease states. In Chapters 26 through 30, we discuss the mechanisms that allow the kidneys to perform these remarkable tasks.

In what body compartments is fluid contained?

-The total body fluid is distributed mainly between two compartments: the extracellular fluid and the intracellular fluid (Figure 25-1). The extracellular fluid is divided into the interstitial fluid and the blood plasma.
-There is another small compartment of fluid that is referred to as transcellular fluid. This compartment includes fluid in the synovial, peritoneal, pericardial, and intraocular spaces, as well as the cerebrospinal fluid; it is usually considered to be a specialized type of extracellular fluid, although in some cases its composition may differ markedly from that of the plasma or interstitial fluid. All the transcellular fluids together constitute about 1 to 2 liters.

Describe the average percent body weight that is water of both men and women

-In the average 70-kilogram adult man, the total body water is about 60 percent of the body weight, or about 42 liters. This percentage can change, depending on age, gender, and degree of obesity. As a person grows older, the percentage of total body weight that is fluid gradually decreases. This is due in part to the fact that aging is usually associated with an increased percentage of the body weight being fat, which decreases the percentage of water in the body.
-Because women normally have more body fat than men, their total body water averages about 50 percent of the body weight. In premature and newborn babies, the total body water ranges from 70 to 75 percent of body weight. Therefore, when discussing the "average" body fluid compartments, we should realize that variations exist, depending on age, gender, and percentage of body fat.

How much water is considered intracellular fluid?

-About 28 of the 42 liters of fluid in the body are inside the 100 trillion cells and are collectively called the intracellular fluid. Thus, the intracellular fluid constitutes about 40 percent of the total body weight in an "average" person.
-The fluid of each cell contains its individual mixture of different constituents, but the concentrations of these substances are similar from one cell to another. In fact, the composition of cell fluids is remarkably similar even in different animals, ranging from the most primitive microorganisms to humans. For this reason, the intracellular fluid of all the different cells together is considered to be one large fluid compartment.

Describe the extracellular fluid.

All the fluids outside the cells are collectively called the extracellular fluid. Together these fluids account for about 20 percent of the body weight, or about 14 liters in a normal 70-kilogram man. The two largest compartments of the extracellular fluid are the interstitial fluid, which makes up more than three fourths (11 liters) of the extracellular fluid, and the plasma, which makes up almost one fourth of the extracellular fluid, or about 3 liters. The plasma is the noncellular part of the blood; it exchanges substances continuously with the interstitial fluid through the pores of the capillary membranes. These pores are highly permeable to almost all solutes in the extracellular fluid except the proteins. Therefore, the extracellular fluids are constantly mixing, so the plasma and interstitial fluids have about the same composition except for proteins, which have a higher concentration in the plasma

What is blood volume?

-Blood contains both extracellular fluid (the fluid in plasma) and intracellular fluid (the fluid in the red blood cells). However, blood is considered to be a separate fluid compartment because it is contained in a chamber of its own, the circulatory system. The blood volume is especially important in the control of cardiovascular dynamics.
-The average blood volume of adults is about 7 percent of body weight, or about 5 liters. About 60 percent of the blood is plasma and 40 percent is red blood cells, but these percentages can vary considerably in different people, depending on gender, weight, and other factors.

What is hematocrit?

-The hematocrit is the fraction of the blood composed of red blood cells, as determined by centrifuging blood in a "hematocrit tube" until the cells become tightly packed in the bottom of the tube. It is impossible to completely pack the red cells together; therefore, about 3 to 4 percent of the plasma remains entrapped among the cells, and the true hematocrit is only about 96 percent of the measured hematocrit.
-In men, the measured hematocrit is normally about 0.40, and in women, it is about 0.36. In severe anemia, the hematocrit may fall as low as 0.10, a value that is barely sufficient to sustain life. Conversely, there are some conditions in which there is excessive production of red blood cells, resulting in polycythemia. In these conditions, the hematocrit can rise to 0.65.

Compare and contrast plasma fluid and interstitial fluid

Because the plasma and interstitial fluid are separated only by highly permeable capillary membranes, their ionic composition is similar. The most important difference between these two compartments is the higher concentration of protein in the plasma; because the capillaries have a low permeability to the plasma proteins, only small amounts of proteins are leaked into the interstitial spaces in most tissues.

Describe the difference in ion charge between the plasma fluid and interstitial fluid

Because of the Donnan effect, the concentration of positively charged ions (cations) is slightly greater (≈2 percent) in the plasma than in the interstitial fluid. The plasma proteins have a net negative charge and, therefore, tend to bind cations, such as sodium and potassium ions, thus holding extra amounts of these cations in the plasma along with the plasma proteins. Conversely, negatively charged ions (anions) tend to have a slightly higher concentration in the interstitial fluid compared with the plasma, because the negative charges of the plasma proteins repel the negatively charged anions. For practical purposes, however, the concentration of ions in the interstitial fluid and in the plasma is considered to be about equal.

What ions are common in extracellular fluid?

The extracellular fluid, including the plasma and the interstitial fluid, contains large amounts of sodium and chloride ions, reasonably large amounts of bicarbonate ions, but only small quantities of potassium, calcium, magnesium, phosphate, and organic acid ions.

What regulates the contents of the extracellular fluid?

The composition of extracellular fluid is carefully regulated by various mechanisms, but especially by the kidneys, as discussed later. This allows the cells to remain continually bathed in a fluid that contains the proper concentration of electrolytes and nutrients for optimal cell function.

What separates intracellular and extracellular fluid? What does intracellular fluid contain?

-The intracellular fluid is separated from the extracellular fluid by a cell membrane that is highly permeable to water but not to most of the electrolytes in the body.
-In contrast to the extracellular fluid, the intracellular fluid contains only small quantities of sodium and chloride ions and almost no calcium ions. Instead, it contains large amounts of potassium and phosphate ions plus moderate quantities of magnesium and sulfate ions, all of which have low concentrations in the extracellular fluid. Also, cells contain large amounts of protein, almost four times as much as in the plasma.

How can one calculate the volume of fluid in a certain compartment?

-Because (V1)(C1)=(V2)(C2), you can rearrange the equation in order to solve for a certain volume.

-For example, if 1 milliliter of a solution containing 10 mg/ml of dye is dispersed into chamber B and the final concentration in the chamber is 0.01 milligram for each milliliter of fluid, the unknown volume of the chamber can be calculated as follows:

-Volume B=(1 mL * 10)/0.01 = 1000 mL

What conditions must be met in order to use the V*C method of calculating the volume of a body compartment?

This method can be used to measure the volume of virtually any compartment in the body as long as (1) the indicator disperses evenly throughout the compartment, (2) the indicator disperses only in the compartment that is being measured, and (3) the indicator is not metabolized or excreted. Several substances can be used to measure the volume of each of the different body fluids.

Describe the measurement of total body volume.

-Radioactive water (tritium, 3H2O) or heavy water (deuterium, 2H2O) can be used to measure total body water. These forms of water mix with the total body water within a few hours after being injected into the blood, and the dilution principle can be used to calculate total body water (Table 25-3).
-Another substance that has been used to measure total body water is antipyrine, which is very lipid soluble and can rapidly penetrate cell membranes and distribute itself uniformly throughout the intracellular and extracellular compartments.

Describe the Measurement of Extracellular Fluid Volume

The volume of extracellular fluid can be estimated using any of several substances that disperse in the plasma and interstitial fluid but do not readily permeate the cell membrane. They include radioactive sodium, radioactive chloride, radioactive iothalamate, thiosulfate ion, and inulin. When any one of these substances is injected into the blood, it usually disperses almost completely throughout the extracellular fluid within 30 to 60 minutes. Some of these substances, however, such as radioactive sodium, may diffuse into the cells in small amounts. Therefore, one frequently speaks of the sodium space or the inulin space, instead of calling the measurement the true extracellular fluid volume.

How can one calculate the intracellular fluid volume?

The intracellular volume cannot be measured directly. However, it can be calculated as:

Total Body Water-Extracellular Fluid Volume

How can one measure plasma volume?

To measure plasma volume, a substance must be used that does not readily penetrate capillary membranes but remains in the vascular system after injection. One of the most commonly used substances for measuring plasma volume is serum albumin labeled with radioactive iodine (125I-albumin). Also, dyes that avidly bind to the plasma proteins, such as Evans blue dye (also called T-1824), can be used to measure plasma volume

How can one calculate the interstitial fund volume?

Interstitial fluid volume cannot be measured directly, but it can be calculated as:

Extracellular Fluid Volume-Plasma Volume

Describe the measurement of blood volume

If one measures plasma volume using the methods described earlier, blood volume can also be calculated if one knows the hematocrit (the fraction of the total blood volume composed of cells), using the following equation:

Plasma Volume/1-Hematocrit

For example, if plasma volume is 3 liters and hematocrit is 0.40, total blood volume would be calculated as

3 Liters/1-0.4=5 Liters

What is a radioactive way to measure blood volume?

Another way to measure blood volume is to inject into the circulation red blood cells that have been labeled with radioactive material. After these mix in the circulation, the radioactivity of a mixed blood sample can be measured and the total blood volume can be calculated using the indicator-dilution principle. A substance frequently used to label the red blood cells is radioactive chromium (51Cr), which binds tightly with the red blood cells.

What determines fluid balance equilibrium between interstitial and plasma fluids?

The relative amounts of extracellular fluid distributed between the plasma and interstitial spaces are determined mainly by the balance of hydrostatic and colloid osmotic forces across the capillary membranes.

What determines the fluid balance equilibrium between the extracellular and intracellular compartments?

The distribution of fluid between intracellular and extracellular compartments, in contrast, is determined mainly by the osmotic effect of the smaller solutes-especially sodium, chloride, and other electrolytes-acting across the cell membrane. The reason for this is that the cell membranes are highly permeable to water but relatively impermeable to even small ions such as sodium and chloride. Therefore, water moves across the cell membrane rapidly and the intracellular fluid remains isotonic with the extracellular fluid.

What is osmosis?

Osmosis is the net diffusion of water across a selectively permeable membrane from a region of high water concentration to one that has a lower water concentration. When a solute is added to pure water, this reduces the concentration of water in the mixture. Thus, the higher the solute concentration in a solution, the lower the water concentration. Further, water diffuses from a region of low solute concentration (high water concentration) to one with a high solute concentration (low water concentration).

Describe the direction and rate of osmosis.

Because cell membranes are relatively impermeable to most solutes but highly permeable to water (i.e., selectively permeable), whenever there is a higher concentration of solute on one side of the cell membrane, water diffuses across the membrane toward the region of higher solute concentration. Thus, if a solute such as sodium chloride is added to the extracellular fluid, water rapidly diffuses from the cells through the cell membranes into the extracellular fluid until the water concentration on both sides of the membrane becomes equal. Conversely, if a solute such as sodium chloride is removed from the extracellular fluid, water diffuses from the extracellular fluid through the cell membranes and into the cells. The rate of diffusion of water is called the rate of osmosis.

Describe the concentration unit that is used to measure the concentration of a solute in solution (in relation to osmosis).

-Because the water concentration of a solution depends on the number of solute particles in the solution, a concentration term is necessary to describe the total concentration of solute particles, regardless of their exact composition. The total number of particles in a solution is measured in osmoles. One osmole (osm) is equal to 1 mole (mol) (6.02 × 1023) of solute particles. -Therefore, a solution containing 1 mole of glucose in each liter has a concentration of 1 osm/L. If a molecule dissociates into two ions (giving two particles), such as sodium chloride ionizing to give chloride and sodium ions, then a solution containing 1 mol/L will have an osmolar concentration of 2 osm/L. Likewise, a solution that contains 1 mole of a molecule that dissociates into three ions, such as sodium sulfate (Na2SO4), will contain 3 osm/L. -Thus, the term osmole refers to the number of osmotically active particles in a solution rather than to the molar concentration.
In general, the osmole is too large a unit for expressing osmotic activity of solutes in the body fluids.
-The term milliosmole (mOsm), which equals 1/1000 osmole, is commonly used.

Differentiate between osmolarity and osmolality.

The osmolal concentration of a solution is called osmolality when the concentration is expressed as osmoles per kilogram of water; it is called osmolarity when it is expressed as osmoles per liter of solution. In dilute solutions such as the body fluids, these two terms can be used almost synonymously because the differences are small. In most cases, it is easier to express body fluid quantities in liters of fluid rather than in kilograms of water. Therefore, most of the calculations used clinically and the calculations expressed in the next several chapters are based on osmolarities rather than osmolalities.

Describe the Calculation of the Osmolarity and Osmotic Pressure of a Solution

-Using van't Hoff's law, one can calculate the potential osmotic pressure of a solution, assuming that the cell membrane is impermeable to the solute.

-For example, the osmotic pressure of a 0.9 percent sodium chloride solution is calculated as follows: A 0.9 percent solution means that there is 0.9 gram of sodium chloride per 100 milliliters of solution, or 9 g/L. Because the molecular weight of sodium chloride is 58.5 g/mol, the molarity of the solution is 9 g/L divided by 58.5 g/mol, or about 0.154 mol/L. Because each molecule of sodium chloride is equal to 2 osmoles, the osmolarity of the solution is 0.154 × 2, or 0.308 osm/L. Therefore, the osmolarity of this solution is 308 mOsm/L. The potential osmotic pressure of this solution would therefore be 308 mOsm/L × 19.3 mm Hg/mOsm/L, or 5944 mm Hg.
-This calculation is only an approximation because sodium and chloride ions do not behave entirely independently in solution because of interionic attraction between them. One can correct for these deviations from the predictions of van't Hoff's law by using a correction factor called the osmotic coefficient. For sodium chloride, the osmotic coefficient is about 0.93. Therefore, the actual osmolarity of a 0.9 percent sodium chloride solution is 308 × 0.93, or about 286 mOsm/L. For practical reasons, the osmotic coefficients of different solutes are sometimes neglected in determining the osmolarity and osmotic pressures of physiologic solutions.

Describe the osmolarity of body fluids.

-Note the approximate osmolarity of the various osmotically active substances in plasma, interstitial fluid, and intracellular fluid. Note that about 80 percent of the total osmolarity of the interstitial fluid and plasma is due to sodium and chloride ions, whereas for intracellular fluid, almost half the osmolarity is due to potassium ions and the remainder is divided among many other intracellular substances.
-As shown in Table 25-2, the total osmolarity of each of the three compartments is about 300 mOsm/L, with the plasma being about 1 mOsm/L greater than that of the interstitial and intracellular fluids. The slight difference between plasma and interstitial fluid is caused by the osmotic effects of the plasma proteins, which maintain about 20 mm Hg greater pressure in the capillaries than in the surrounding interstitial spaces, as discussed in Chapter 16.

Why do we have to "correct" for the calculated osmolar concentrations of body fluids?

The reason for these corrections is that cations and anions exert interionic attraction, which can cause a slight decrease in the osmotic "activity" of the dissolved substance.

Describe the osmotic pressure that can develop from relatively small changes in solute concentration.

Large osmotic pressures can develop across the cell membrane with relatively small changes in the concentrations of solutes in the extracellular fluid. As discussed earlier, for each milliosmole concentration gradient of an impermeant solute (one that will not permeate the cell membrane), about 19.3 mm Hg osmotic pressure is exerted across the cell membrane. If the cell membrane is exposed to pure water and the osmolarity of intracellular fluid is 282 mOsm/L, the potential osmotic pressure that can develop across the cell membrane is more than 5400 mm Hg. This demonstrates the large force that can move water across the cell membrane when the intracellular and extracellular fluids are not in osmotic equilibrium. As a result of these forces, relatively small changes in the concentration of impermeant solutes in the extracellular fluid can cause large changes in cell volume.

Explain the effects of different solutions of cell volume.

-If a cell is placed in a solution of impermeant solutes having an osmolarity of 282 mOsm/L, the cells will not shrink or swell because the water concentration in the intracellular and extracellular fluids is equal and the solutes cannot enter or leave the cell. Such a solution is said to be isotonic because it neither shrinks nor swells the cells. Examples of isotonic solutions include a 0.9 percent solution of sodium chloride or a 5 percent glucose solution. These solutions are important in clinical medicine because they can be infused into the blood without the danger of upsetting osmotic equilibrium between the intracellular and extracellular fluids.
-If a cell is placed into a hypotonic solution that has a lower concentration of impermeant solutes (<282 mOsm/L), water will diffuse into the cell, causing it to swell; water will continue to diffuse into the cell, diluting the intracellular fluid while also concentrating the extracellular fluid until both solutions have about the same osmolarity. Solutions of sodium chloride with a concentration of less than 0.9 percent are hypotonic and cause cells to swell.
-If a cell is placed in a hypertonic solution having a higher concentration of impermeant solutes, water will flow out of the cell into the extracellular fluid, concentrating the intracellular fluid and diluting the extracellular fluid. In this case, the cell will shrink until the two concentrations become equal. Sodium chloride solutions of greater than 0.9 percent are hypertonic.

Describe Isosmotic, Hyperosmotic, and Hypo-osmotic Fluids

-The terms isotonic, hypotonic, and hypertonic refer to whether solutions will cause a change in cell volume. The tonicity of solutions depends on the concentration of impermeant solutes. Some solutes, however, can permeate the cell membrane. Solutions with an osmolarity the same as the cell are called isosmotic, regardless of whether the solute can penetrate the cell membrane.
-The terms hyperosmotic and hypo-osmotic refer to solutions that have a higher or lower osmolarity, respectively, compared with the normal extracellular fluid, without regard for whether the solute permeates the cell membrane. Highly permeating substances, such as urea, can cause transient shifts in fluid volume between the intracellular and extracellular fluids, but given enough time, the concentrations of these substances eventually become equal in the two compartments and have little effect on intracellular volume under steady-state conditions.

Explain how Osmotic Equilibrium Between Intracellular and Extracellular Fluids Is Rapidly Attained

The transfer of fluid across the cell membrane occurs so rapidly that any differences in osmolarities between these two compartments are usually corrected within seconds or, at the most, minutes. This rapid movement of water across the cell membrane does not mean that complete equilibrium occurs between the intracellular and extracellular compartments throughout the whole body within the same short period. The reason for this is that fluid usually enters the body through the gut and must be transported by the blood to all tissues before complete osmotic equilibrium can occur. It usually takes about 30 minutes to achieve osmotic equilibrium everywhere in the body after drinking water.

What factors can change the extracellular and intracellular volumes of water?

Some of the different factors that can cause extracellular and intracellular volumes to change markedly are ingestion of water, dehydration, intravenous infusion of different types of solutions, loss of large amounts of fluid from the gastrointestinal tract, and loss of abnormal amounts of fluid by sweating or through the kidneys.

How can one calculate both the changes in intracellular and extracellular fluid volumes?

One can calculate both the changes in intracellular and extracellular fluid volumes and the types of therapy that should be instituted if the following basic principles are kept in mind:
1. Water moves rapidly across cell membranes; therefore, the osmolarities of intracellular and extracellular fluids remain almost exactly equal to each other except for a few minutes after a change in one of the compartments.
2. Cell membranes are almost completely impermeable to many solutes; therefore, the number of osmoles in the extracellular or intracellular fluid generally remains constant unless solutes are added to or lost from the extracellular compartment.

With these basic principles in mind, we can analyze the effects of different abnormal fluid conditions on extracellular and intracellular fluid volumes and osmolarities

What happens if isotonic saline is infused into a patient?

If an isotonic saline solution is added to the extracellular fluid compartment, the osmolarity of the extracellular fluid does not change; therefore, no osmosis occurs through the cell membranes. The only effect is an increase in extracellular fluid volume (Figure 25-6A). The sodium and chloride largely remain in the extracellular fluid because the cell membrane behaves as though it were virtually impermeable to the sodium chloride.

What happens if a hypertonic saline solution is infused into a patient?

If a hypertonic solution is added to the extracellular fluid, the extracellular osmolarity increases and causes osmosis of water out of the cells into the extracellular compartment (see Figure 25-6B). Again, almost all the added sodium chloride remains in the extracellular compartment and fluid diffuses from the cells into the extracellular space to achieve osmotic equilibrium. The net effect is an increase in extracellular volume (greater than the volume of fluid added), a decrease in intracellular volume, and a rise in osmolarity in both compartments.

What happens if a hypotonic saline solution is infused into a patient?

If a hypotonic solution is added to the extracellular fluid, the osmolarity of the extracellular fluid decreases and some of the extracellular water diffuses into the cells until the intracellular and extracellular compartments have the same osmolarity (see Figure 25-6C). Both the intracellular and the extracellular volumes are increased by the addition of hypotonic fluid, although the intracellular volume increases to a greater extent.

If 2 liters of a hypertonic 3.0 percent sodium chloride solution are infused into the extracellular fluid compartment of a 70-kilogram patient whose initial plasma osmolarity is 280 mOsm/L, what would be the intracellular and extracellular fluid volumes and osmolarities after osmotic equilibrium?

1. The first step is to calculate the initial conditions, including the volume, concentration, and total milliosmoles in each compartment. Assuming that extracellular fluid volume is 20 percent of body weight and intracellular fluid volume is 40 percent of body weight, the following volumes and concentrations can be calculated.
2. -Next, we calculate the total milliosmoles added to the extracellular fluid in 2 liters of 3.0 percent sodium chloride. A 3.0 percent solution means that there are 3.0 g/100 ml, or 30 grams of sodium chloride per liter. Because the molecular weight of sodium chloride is about 58.5 g/mol, this means that there is about 0.513 mole of sodium chloride per liter of solution. For 2 liters of solution, this would be 1.026 mole of sodium chloride. Because 1 mole of sodium chloride is about equal to 2 osmoles (sodium chloride has two osmotically active particles per mole), the net effect of adding 2 liters of this solution is to add 2051 milliosmoles of sodium chloride to the extracellular fluid.
-In Step 2, we calculate the instantaneous effect of adding 2051 milliosmoles of sodium chloride to the extracellular fluid along with 2 liters of volume. There would be no change in the intracellular fluid concentration or volume, and there would be no osmotic equilibrium. In the extracellular fluid, however, there would be an additional 2051 milliosmoles of total solute, yielding a total of 5791 milliosmoles. Because the extracellular compartment now has 16 liters of volume, the concentration can be calculated by dividing 5791 milliosmoles by 16 liters to yield a concentration of 373 mOsm/L. Thus, the following values would occur instantly after adding the solution.
3. In the third step, we calculate the volumes and concentrations that would occur within a few minutes after osmotic equilibrium develops. In this case, the concentrations in the intracellular and extracellular fluid compartments would be equal and can be calculated by dividing the total milliosmoles in the body, 13,811, by the total volume, which is now 44 liters. This yields a concentration of 313.9 mOsm/L. Therefore, all the body fluid compartments will have this same concentration after osmotic equilibrium. Assuming that no solute or water has been lost from the body and that there is no movement of sodium chloride into or out of the cells, we then calculate the volumes of the intracellular and extracellular compartments. The intracellular fluid volume is calculated by dividing the total milliosmoles in the intracellular fluid (7840) by the concentration (313.9 mOsm/L), to yield a volume of 24.98 liters. Extracellular fluid volume is calculated by dividing the total milliosmoles in extracellular fluid (5971) by the concentration (313.9 mOsm/L), to yield a volume of 19.02 liters. Again, these calculations are based on the assumption that the sodium chloride added to the extracellular fluid remains there and does not move into the cells.
-Thus, one can see from this example that adding 2 liters of a hypertonic sodium chloride solution causes more than a 5-liter increase in extracellular fluid volume while decreasing intracellular fluid volume by almost 3 liters.

Describe the infusion of glucose solutions into patients

Many types of solutions are administered intravenously to provide nutrition to people who cannot otherwise take adequate amounts of nutrition. Glucose solutions are widely used, and amino acid and homogenized fat solutions are used to a lesser extent. When these solutions are administered, their concentrations of osmotically active substances are usually adjusted nearly to isotonicity, or they are given slowly enough that they do not upset the osmotic equilibrium of the body fluids. After the glucose or other nutrients are metabolized, an excess of water often remains, especially if additional fluid is ingested. Ordinarily, the kidneys excrete this in the form of a very dilute urine. The net result, therefore, is the addition of only nutrients to the body.

What are Hyponatremia and Hypernatremia?

The primary measurement that is readily available to the clinician for evaluating a patient's fluid status is the plasma sodium concentration. Plasma osmolarity is not routinely measured, but because sodium and its associated anions (mainly chloride) account for more than 90 percent of the solute in the extracellular fluid, plasma sodium concentration is a reasonable indicator of plasma osmolarity under many conditions. When plasma sodium concentration is reduced more than a few milliequivalents below normal (about 142 mEq/L), a person is said to have hyponatremia. When plasma sodium concentration is elevated above normal, a person is said to have hypernatremia.

What causes Hyponatremia?

-Decreased plasma sodium concentration can result from loss of sodium chloride from the extracellular fluid or addition of excess water to the extracellular fluid (Table 25-4). A primary loss of sodium chloride usually results in hyponatremia-dehydration and is associated with decreased extracellular fluid volume. Conditions that can cause hyponatremia owing to loss of sodium chloride include diarrhea and vomiting. Overuse of diuretics that inhibit the ability of the kidneys to conserve sodium and certain types of sodium-wasting kidney diseases can also cause modest degrees of hyponatremia. Finally, Addison's disease, which results from decreased secretion of the hormone aldosterone, impairs the ability of the kidneys to reabsorb sodium and can cause a modest degree of hyponatremia.
-Hyponatremia can also be associated with excess water retention, which dilutes the sodium in the extracellular fluid, a condition that is referred to as hyponatremia-overhydration. For example, excessive secretion of antidiuretic hormone, which causes the kidney tubules to reabsorb more water, can lead to hyponatremia and overhydration.

Describe the consequences of fast and slow developing hyponatremia.

-Rapid changes in cell volume as a result of hyponatremia can have profound effects on tissue and organ function, especially the brain. A rapid reduction in plasma sodium concentration, for example, can cause brain cell edema and neurological symptoms, including headache, nausea, lethargy, and disorientation. If plasma sodium concentration rapidly falls below 115 to 120 mmol/L, brain swelling may lead to seizures, coma, permanent brain damage, and death. Because the skull is rigid, the brain cannot increase its volume by more than about 10 percent without it being forced down the neck (herniation), which can lead to permanent brain injury and death.
-When hyponatremia evolves more slowly over several days, the brain and other tissues respond by transporting sodium, chloride, potassium, and organic solutes, such as glutamate, from the cells into the extracellular compartment. This attenuates osmotic flow of water into the cells and swelling of the tissues (Figure 25-7).
Transport of solutes from the cells during slowly developing hyponatremia, however, can make the brain vulnerable to injury if the hyponatremia is corrected too rapidly. When hypertonic solutions are added too rapidly to correct hyponatremia, this can outpace the brain's ability to recapture the solutes lost from the cells and may lead to osmotic injury of the neurons that is associated with demyelination, a loss of the myelin sheath from nerves. This osmotic-mediated demyelination of neurons can be avoided by limiting the correction of chronic hyponatremia to less than 10 to 12 mmol/L in 24 hours and to less than 18 mmol/L in 48 hours. This slow rate of correction permits the brain to recover the lost osmoles that have occurred as a result of adaptation to chronic hyponatremia.
-Hyponatremia is the most common electrolyte disorder encountered in clinical practice and may occur in up to 15% to 25% of hospitalized patients.

What causes hypernatremia?

-Increased plasma sodium concentration, which also causes increased osmolarity, can be due to either loss of water from the extracellular fluid, which concentrates the sodium ions, or excess sodium in the extracellular fluid. When there is primary loss of water from the extracellular fluid, this results in hypernatremia-dehydration. This condition can occur from an inability to secrete antidiuretic hormone, which is needed for the kidneys to conserve water. As a result of lack of antidiuretic hormone, the kidneys excrete large amounts of dilute urine (a disorder referred to as diabetes insipidus), causing dehydration and increased concentration of sodium chloride in the extracellular fluid. In certain types of renal diseases, the kidneys cannot respond to antidiuretic hormone, also causing a type of nephrogenic diabetes insipidus. A more common cause of hypernatremia associated with decreased extracellular fluid volume is dehydration caused by water intake that is less than water loss, as can occur with sweating during prolonged, heavy exercise.
-Hypernatremia can also occur as a result of excessive sodium chloride added to the extracellular fluid. This often results in hypernatremia-overhydration because excess extracellular sodium chloride is usually associated with at least some degree of water retention by the kidneys as well. For example, excessive secretion of the sodium-retaining hormone aldosterone can cause a mild degree of hypernatremia and overhydration. The reason that the hypernatremia is not more severe is that increased aldosterone secretion causes the kidneys to reabsorb greater amounts of water, as well as sodium.
-Thus, in analyzing abnormalities of plasma sodium concentration and deciding on proper therapy, one should first determine whether the abnormality is caused by a primary loss or gain of sodium or a primary loss or gain of water.

What are the consequences of hypernatremia?

-Hypernatremia is much less common than hyponatremia and severe symptoms usually occur only with rapid and large increases in plasma sodium concentration above 158 to 160 mmol/L. One reason for this is that hypernatremia promotes intense thirst that protects against a large increase in plasma and extracellular fluid sodium, as discussed in Chapter 28. However, severe hypernatremia can occur in patients with hypothalamic lesions that impair their sense of thirst, in infants who may not have ready access to water, or elderly patients with altered mental status.
-Correction of hypernatremia can be achieved by administering hypo-osmotic sodium chloride or dextrose solutions. However, it is prudent to correct the hypernatremia slowly in patients who have had chronic increases in plasma sodium concentration. The reason for this is that hypernatremia also activates defense mechanisms that protect the cell from changes in volume. These defense mechanisms are opposite to those that occur for hyponatremia and consist of mechanisms that increase the intracellular concentration of sodium and other solutes.

What is edema?

Edema refers to the presence of excess fluid in the body tissues. In most instances, edema occurs mainly in the extracellular fluid compartment, but it can involve intracellular fluid as well.

Describe intracellular edema.

Three conditions are especially prone to cause intracellular swelling:
(1) hyponatremia, as discussed earlier
(2) depression of the metabolic systems of the tissues
(3) lack of adequate nutrition to the cells.
-For example, when blood flow to a tissue is decreased, the delivery of oxygen and nutrients is reduced. If the blood flow becomes too low to maintain normal tissue metabolism, the cell membrane ionic pumps become depressed. When this occurs, sodium ions that normally leak into the interior of the cell can no longer be pumped out of the cells and the excess intracellular sodium ions cause osmosis of water into the cells. Sometimes this can increase intracellular volume of a tissue area-even of an entire ischemic leg, for example-to two to three times normal. When this occurs, it is usually a prelude to death of the tissue.
-Intracellular edema can also occur in inflamed tissues. Inflammation usually increases cell membrane permeability, allowing sodium and other ions to diffuse into the interior of the cell, with subsequent osmosis of water into the cells.

Describe extracellular edema.

Extracellular fluid edema occurs when there is excess fluid accumulation in the extracellular spaces. There are two general causes of extracellular edema:
(1) abnormal leakage of fluid from the plasma to the interstitial spaces across the capillaries
(2) failure of the lymphatics to return fluid from the interstitium back into the blood, often called lymphedema.
-The most common clinical cause of interstitial fluid accumulation is excessive capillary fluid filtration.

What factors increase capillary filtration?

To understand the causes of excessive capillary filtration, it is useful to review the determinants of capillary filtration discussed in Chapter 16. Mathematically, capillary filtration rate can be expressed as where Kf is the capillary filtration coefficient (the product of the permeability and surface area of the capillaries), Pc is the capillary hydrostatic pressure, Pif is the interstitial fluid hydrostatic pressure, πc is the capillary plasma colloid osmotic pressure, and πif is the interstitial fluid colloid osmotic pressure. From this equation, one can see that any one of the following changes can increase the capillary filtration rate:
-Increased capillary filtration coefficient.
-Increased capillary hydrostatic pressure.
-Decreased plasma colloid osmotic pressure.

What is Lymphedema?

-When lymph vessel function is greatly impaired, due to blockage or loss of the lymph vessels, edema can become especially severe because plasma proteins that leak into the interstitium have no other way to be removed. The rise in protein concentration raises the colloid osmotic pressure of the interstitial fluid, which draws even more fluid out of the capillaries.
-Blockage of lymph flow can be especially severe with infections of the lymph nodes, such as occurs with infection by filaria nematodes (Wuchereria bancrofti), which are microscopic, threadlike worms. The adult worms live in the human lymph system and are spread from person to person by mosquitoes. People with filarial infections can suffer from severe lymphedema and elephantiasis and in men, swelling of the scrotum, called hydrocele. Lymphatic filariasis affects over 120 million people in 80 countries throughout the tropics and subtropics of Asia, Africa, the Western Pacific, and parts of the Caribbean and South America.
-Lymphedema can also occur in certain types of cancer or after surgery in which lymph vessels are removed or obstructed. For example, large numbers of lymph vessels are removed during radical mastectomy, impairing removal of fluid from the breast and arm areas and causing edema and swelling of the tissue spaces. A few lymph vessels eventually regrow after this type of surgery, so the interstitial edema is usually temporary.

Give a comprehensive summary of the causes of extracellular edema.

1. Increased capillary pressure
2. Decreased plasma proteins
3. Increased capillary permeability
4. Blockage of lymph return

What factors lead to Increased capillary pressure and extracellular edema?

1. Excessive kidney retention of salt and water
-Acute or chronic kidney failure
-Mineralocorticoid excess
2. High venous pressure and venous constriction
-Heart failure
-Venous obstruction
-Failure of venous pumps
(a) Paralysis of muscles
(b) Immobilization of parts of the body
(c) Failure of venous valves
3. Decreased arteriolar resistance
-Excessive body heat
-Insufficiency of sympathetic nervous system
-Vasodilator drugs

What factors lead to decreased plasma proteins and extracellular edema?

1. Loss of proteins in urine (nephrotic syndrome)
2. Loss of protein from denuded skin areas
-Burns
-Wounds
3. Failure to produce proteins
-Liver disease (e.g., cirrhosis)
-Serious protein or caloric malnutrition

What factors lead to increased capillary permeability and extracellular edema?

-Immune reactions that cause release of histamine and other immune products
-Toxins
-Bacterial infections
-Vitamin deficiency, especially vitamin C
-Prolonged ischemia
-Burns

What factors lead to blockage if lymph and extracellular edema?

-Cancer
-Infections (e.g., filaria nematodes)
-Surgery
-Congenital absence or abnormality of lymphatic vessels

Discuss edema caused by heart failure

-One of the most serious and most common causes of edema is heart failure. In heart failure, the heart fails to pump blood normally from the veins into the arteries; this raises venous pressure and capillary pressure, causing increased capillary filtration. In addition, the arterial pressure tends to fall, causing decreased excretion of salt and water by the kidneys, which increases blood volume and further raises capillary hydrostatic pressure to cause still more edema. Also, blood flow to the kidneys is reduced in heart failure and this stimulates secretion of renin, causing increased formation of angiotensin II and increased secretion of aldosterone, both of which cause additional salt and water retention by the kidneys. Thus, in untreated heart failure, all these factors acting together cause serious generalized extracellular edema.
-In patients with left-sided heart failure but without significant failure of the right side of the heart, blood is pumped into the lungs normally by the right side of the heart but cannot escape easily from the pulmonary veins to the left side of the heart because this part of the heart has been greatly weakened. Consequently, all the pulmonary vascular pressures, including pulmonary capillary pressure, rise far above normal, causing serious and life-threatening pulmonary edema. When untreated, fluid accumulation in the lungs can rapidly progress, causing death within a few hours.

Discuss Edema Caused by Decreased Kidney Excretion of Salt and Water

As discussed earlier, most sodium chloride added to the blood remains in the extracellular compartment, and only small amounts enter the cells. Therefore, in kidney diseases that compromise urinary excretion of salt and water, large amounts of sodium chloride and water are added to the extracellular fluid. Most of this salt and water leaks from the blood into the interstitial spaces, but some remains in the blood. The main effects of this are to cause
(1) widespread increases in interstitial fluid volume (extracellular edema)
(2) hypertension because of the increase in blood volume, as explained in Chapter 19.
-As an example, children who develop acute glomerulonephritis, in which the renal glomeruli are injured by inflammation and therefore fail to filter adequate amounts of fluid, also develop serious extracellular fluid edema in the entire body; along with the edema, these children usually develop severe hypertension.

Discuss Edema Caused by Decreased Plasma Proteins

-A reduction in plasma concentration of proteins because of either failure to produce normal amounts of proteins or leakage of proteins from the plasma causes the plasma colloid osmotic pressure to fall. This leads to increased capillary filtration throughout the body and extracellular edema.
-One of the most important causes of decreased plasma protein concentration is loss of proteins in the urine in certain kidney diseases, a condition referred to as nephrotic syndrome. Multiple types of renal diseases can damage the membranes of the renal glomeruli, causing the membranes to become leaky to the plasma proteins and often allowing large quantities of these proteins to pass into the urine. When this loss exceeds the ability of the body to synthesize proteins, a reduction in plasma protein concentration occurs. Serious generalized edema occurs when the plasma protein concentration falls below 2.5 g/100 ml.

Discuss edema caused by liver cirrhosis?

-Cirrhosis of the liver is another condition that causes a reduction in plasma protein concentration. Cirrhosis means development of large amounts of fibrous tissue among the liver parenchymal cells. One result is failure of these cells to produce sufficient plasma proteins, leading to decreased plasma colloid osmotic pressure and the generalized edema that goes with this condition.
Another way liver cirrhosis causes edema is that the liver fibrosis sometimes compresses the abdominal portal venous drainage vessels as they pass through the liver before emptying back into the general circulation. Blockage of this portal venous outflow raises capillary hydrostatic pressure throughout the gastrointestinal area and further increases filtration of fluid out of the plasma into the intra-abdominal areas. When this occurs, the combined effects of decreased plasma protein concentration and high portal capillary pressures cause transudation of large amounts of fluid and protein into the abdominal cavity, a condition referred to as ascites.

Discuss Safety Factors That Normally Prevent Edema

Even though many disturbances can cause edema, usually the abnormality must be severe before serious edema develops. The reason for this is that three major safety factors prevent excessive fluid accumulation in the interstitial spaces:
(1) low compliance of the interstitium when interstitial fluid pressure is in the negative pressure range
(2) the ability of lymph flow to increase 10- to 50-fold
(3) washdown of interstitial fluid protein concentration, which reduces interstitial fluid colloid osmotic pressure as capillary filtration increases.

Discuss the Anti-Edema Safety Factor Caused by Low Compliance of the Interstitium in the Negative Pressure Range

-How does the low compliance of the tissues in the negative pressure range act as a safety factor against edema? To answer this question, recall the determinants of capillary filtration discussed previously. When interstitial fluid hydrostatic pressure increases, this increased pressure tends to oppose further capillary filtration. Therefore, as long as the interstitial fluid hydrostatic pressure is in the negative pressure range, small increases in interstitial fluid volume cause relatively large increases in interstitial fluid hydrostatic pressure, opposing further filtration of fluid into the tissues.
-Because the normal interstitial fluid hydrostatic pressure is -3 mm Hg, the interstitial fluid hydrostatic pressure must increase by about 3 mm Hg before large amounts of fluid will begin to accumulate in the tissues. Therefore, the safety factor against edema is a change of interstitial fluid pressure of about 3 mm Hg.
Once interstitial fluid pressure rises above 0 mm Hg, the compliance of the tissues increases markedly, allowing large amounts of fluid to accumulate in the tissues with relatively small additional increases in interstitial fluid hydrostatic pressure. Thus, in the positive tissue pressure range, this safety factor against edema is lost because of the large increase in compliance of the tissues.

Describe the Importance of Interstitial Gel in Preventing Fluid Accumulation in the Interstitium

-Note in Figure 25-8 that in normal tissues with negative interstitial fluid pressure, virtually all the fluid in the interstitium is in gel form. That is, the fluid is bound in a proteoglycan meshwork so that there are virtually no "free" fluid spaces larger than a few hundredths of a micrometer in diameter. The importance of the gel is that it prevents fluid from flowing easily through the tissues because of impediment from the "brush pile" of trillions of proteoglycan filaments. Also, when the interstitial fluid pressure falls to very negative values, the gel does not contract greatly because the meshwork of proteoglycan filaments offers an elastic resistance to compression. In the negative fluid pressure range, the interstitial fluid volume does not change greatly, regardless of whether the degree of suction is only a few millimeters of mercury negative pressure or 10 to 20 mm Hg negative pressure. In other words, the compliance of the tissues is very low in the negative pressure range.
-By contrast, when interstitial fluid pressure rises to the positive pressure range, there is a tremendous accumulation of free fluid in the tissues. In this pressure range, the tissues are compliant, allowing large amounts of fluid to accumulate with relatively small additional increases in interstitial fluid hydrostatic pressure. Most of the extra fluid that accumulates is "free fluid" because it pushes the brush pile of proteoglycan filaments apart. Therefore, the fluid can flow freely through the tissue spaces because it is not in gel form. When this occurs, the edema is said to be pitting edema because one can press the thumb against the tissue area and push the fluid out of the area. When the thumb is removed, a pit is left in the skin for a few seconds until the fluid flows back from the surrounding tissues. This type of edema is distinguished from nonpitting edema, which occurs when the tissue cells swell instead of the interstitium or when the fluid in the interstitium becomes clotted with fibrinogen so that it cannot move freely within the tissue spaces

Discuss the Importance of the Proteoglycan Filaments as a "Spacer" for the Cells and in Preventing Rapid Flow of Fluid in the Tissues

-The proteoglycan filaments, along with much larger collagen fibrils in the interstitial spaces, act as a "spacer" between the cells. Nutrients and ions do not diffuse readily through cell membranes; therefore, without adequate spacing between the cells, these nutrients, electrolytes, and cell waste products could not be rapidly exchanged between the blood capillaries and cells located at a distance from one another.
-The proteoglycan filaments also prevent fluid from flowing too easily through the tissue spaces. If it were not for the proteoglycan filaments, the simple act of a person standing up would cause large amounts of interstitial fluid to flow from the upper body to the lower body. When too much fluid accumulates in the interstitium, as occurs in edema, this extra fluid creates large channels that allow the fluid to flow readily through the interstitium. Therefore, when severe edema occurs in the legs, the edema fluid often can be decreased by simply elevating the legs.
-Even though fluid does not flow easily through the tissues in the presence of the compacted proteoglycan filaments, different substances within the fluid can diffuse through the tissues at least 95 percent as easily as they normally diffuse. Therefore, the usual diffusion of nutrients to the cells and the removal of waste products from the cells are not compromised by the proteoglycan filaments of the interstitium.

Describe the role of Increased Lymph Flow as a Safety Factor Against Edema

-A major function of the lymphatic system is to return to the circulation the fluid and proteins filtered from the capillaries into the interstitium. Without this continuous return of the filtered proteins and fluid to the blood, the plasma volume would be rapidly depleted, and interstitial edema would occur.
-The lymphatics act as a safety factor against edema because lymph flow can increase 10- to 50-fold when fluid begins to accumulate in the tissues. This allows the lymphatics to carry away large amounts of fluid and proteins in response to increased capillary filtration, preventing the interstitial pressure from rising into the positive pressure range. The safety factor caused by increased lymph flow has been calculated to be about 7 mm Hg.

Describe the "Washdown" of the Interstitial Fluid Protein as a Safety Factor Against Edema

-As increased amounts of fluid are filtered into the interstitium, the interstitial fluid pressure increases, causing increased lymph flow. In most tissues the protein concentration of the interstitium decreases as lymph flow is increased, because larger amounts of protein are carried away than can be filtered out of the capillaries; the reason for this is that the capillaries are relatively impermeable to proteins, compared with the lymph vessels. Therefore, the proteins are "washed out" of the interstitial fluid as lymph flow increases.
-Because the interstitial fluid colloid osmotic pressure caused by the proteins tends to draw fluid out of the capillaries, decreasing the interstitial fluid proteins lowers the net filtration force across the capillaries and tends to prevent further accumulation of fluid. The safety factor from this effect has been calculated to be about 7 mm Hg.

Summarize the Safety Factors That Prevent Edema

Putting together all the safety factors against edema, we find the following:
1. The safety factor caused by low tissue compliance in the negative pressure range is about 3 mm Hg.
2. The safety factor caused by increased lymph flow is about 7 mm Hg.
3. The safety factor caused by washdown of proteins from the interstitial spaces is about 7 mm Hg.
-Therefore, the total safety factor against edema is about 17 mm Hg. This means that the capillary pressure in a peripheral tissue could theoretically rise by 17 mm Hg, or approximately double the normal value, before marked edema would occur.

Describe the idea of Fluids in the "Potential Spaces" of the Body

Some examples of "potential spaces" are pleural cavity, pericardial cavity, peritoneal cavity, and synovial cavities, including both the joint cavities and the bursae. Virtually all these potential spaces have surfaces that almost touch each other, with only a thin layer of fluid in between, and the surfaces slide over each other. To facilitate the sliding, a viscous proteinaceous fluid lubricates the surfaces.

How does fluid leave the potential spaces of the body?

-Fluid Is Exchanged Between the Capillaries and the Potential Spaces
-The surface membrane of a potential space usually does not offer significant resistance to the passage of fluids, electrolytes, or even proteins, which all move back and forth between the space and the interstitial fluid in the surrounding tissue with relative ease. Therefore, each potential space is in reality a large tissue space. Consequently, fluid in the capillaries adjacent to the potential space diffuses not only into the interstitial fluid but also into the potential space.

What drains protein from potential spaces?

-Lymphatic Vessels Drain Protein from the Potential Spaces
-Proteins collect in the potential spaces because of leakage out of the capillaries, similar to the collection of protein in the interstitial spaces throughout the body. The protein must be removed through lymphatics or other channels and returned to the circulation. Each potential space is either directly or indirectly connected with lymph vessels. In some cases, such as the pleural cavity and peritoneal cavity, large lymph vessels arise directly from the cavity itself.

Discuss edema in potential spaces.

-Edema Fluid in the Potential Spaces Is Called "Effusion."
-When edema occurs in the subcutaneous tissues adjacent to the potential space, edema fluid usually collects in the potential space as well and this fluid is called effusion. Thus, lymph blockage or any of the multiple abnormalities that can cause excessive capillary filtration can cause effusion in the same way that interstitial edema is caused. The abdominal cavity is especially prone to collect effusion fluid, and in this instance, the effusion is called ascites. In serious cases, 20 liters or more of ascitic fluid can accumulate.
-The other potential spaces, such as the pleural cavity, pericardial cavity, and joint spaces, can become seriously swollen when there is generalized edema. Also, injury or local infection in any one of the cavities often blocks the lymph drainage, causing isolated swelling in the cavity.
-The dynamics of fluid exchange in the pleural cavity are discussed in detail in Chapter 38. These dynamics are mainly representative of all the other potential spaces as well. It is especially interesting that the normal fluid pressure in most or all of the potential spaces in the nonedematous state is negative in the same way that this pressure is negative (subatmospheric) in loose subcutaneous tissue. For instance, the interstitial fluid hydrostatic pressure is normally about -7 to -8 mm Hg in the pleural cavity, -3 to -5 mm Hg in the joint spaces, and -5 to -6 mm Hg in the pericardial cavity.

What type of solution should be infused into a person who has lost a great deal of blood (gun shot wound, or stab wound)?

-0.9% NaCl in water--physiological saline solution
-Blood and electrolytes are lost at the same rate, therefore, we are dealing with the same osmotic pressures as in a normal human subject.
-Also, you want to make sure that the volume of the extracellular compartment is what increases (to maintain cardiac output), therefore, you wouldn't want to use a solution that primarily enters cells.

Why would you use 5% dextrose solution?

-The solution will enter the INTRACELLULAR compartment
-If you just want to increase the volume of the extracellular compartment, you should use NaCl

What is the 60-40-20 rule?

-60 % of body weight is water
-40% of body weight is intracellular fluids
-20% of body weight is extracellular fluid

If an individual is dehydrated, what fluid should you infuse?

-They are missing fluid in the extracellular AND intracellular compartments
-Use 0.45% NaCl in water or 5% dextrose
-Both of these solutions will cause water to move into the cells, while also adding fluid to the extracellular environment. (For NaCl, water concentration is now greater outside of the cell, so water will diffuse into the cell. For dextrose, although the concentrations are equal outside and inside the cell, the dextrose will be taken up by the cells slowly, and will cause the water to begin to diffuse down the newly established gradient and into the cells)
-Preferably use NaCl .45%, because it will move water into the cells more quickly

What's the difference between blood loss and dehydration?

-Blood loss primarily causes extracellular fluid loss, and you should use a solution to establish an increase in primarily extracellular fluids
-Dehydration causes extracellular AND intracellular fluid loss, so you want to use a solution that will not only reestablish the extracellular fluid volume, but a fluid that will ALSO push water into the extracellular environment.

*What matins the osmotic equilibrium between the EC compartment and IC compartment?*

Integration of active and passive transport mechanism across the semipermeable cell membrane maintains osmotic equilibrium between the intra‐ and extra‐ cellular compartments.

*What controls the net movement of water between the EC compartment and IC compartment?*

The free water gradient controls the net movement of water between compartments.

*What defines free water?*

Free water is defined by the number of non‐diffusible substances

*What are sodium and potassium the most important osmotic agents?*

Sodium and potassium are the most important osmotic substances because; a) of their high concentrations; and, b) they are segregated by Na+K+ATPase

*How many compartments are there within the body when it comes to fluid balance (theoretically)?*

The summed actions of the body's cells is to functionally create two fluid compartments

*How can the size and osmolarity of fluid compartments be calculated?*

The size and osmolality of fluid compartments can be calculated based on generally assumed values.

*How can changes in fluid compartment volume and concentration be predicted?*

Changes in fluid compartment volume and concentration can be predicted based on knowledge of the body and infusate.

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